Role of medical treatment for symptomatic leiomyoma management in premenopausal women;Place des traitements médicaux : indication, durée, efficacité, chez la femme porteuse de fibromes utérins symptomatiques en période d'activité génitale

Journal de Gynecologie Obstetrique et Biologie de la Reproduction

Volumn 40, Issue 8, 2011, Pages 858-874

  Koskas, M ^a   Chabbert Buffet, N ^b   Douvier, S ^c   Huchon, C ^d   Paganelli, E ^e   Derrien, J ^f  

^a BICHAT HOSPITAL   (France)

^b HÔPITAL TENON   (France)

^c DIJON UNIVERSITY HOSPITAL   (France)

^d Service de Gynécologie Obstétrique et Médecine de la Reproduction   (France)

^e Collge de Gynécologie Rhône Alpes ^*  (France)

^f NONE   (France)

Author keywords

Bleeding; Leiomyomata; Medical treatment; Pelvic pain

Indexed keywords

AMINOGLUTETHIMIDE; ANASTROZOLE; DANAZOL; ESTROGEN; FADROZOLE; FULVESTRANT; GESTAGEN; GONADORELIN AGONIST; HEMOGLOBIN; INTERFERON; LETROZOLE; LEVONORGESTREL; LYNESTRENOL; MIFEPRISTONE; PIRFENIDONE; PREGNANE DERIVATIVE; RALOXIFENE; TAMOXIFEN; TIBOLONE; TRANEXAMIC ACID;

ARTICLE; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MEGADOSE; DYSMENORRHEA; ENDOMETRIUM HYPERPLASIA; FEMALE; HEMOGLOBIN BLOOD LEVEL; HOT FLUSH; HUMAN; MENORRHAGIA AND METRORRHAGIA; MENSTRUATION; PELVIS PAIN SYNDROME; PREMENOPAUSE; PRESCRIPTION; TUMOR VOLUME; UTERUS MYOMA;

EID: 82455199197     PISSN: 03682315     EISSN: 17730430     Source Type: Journal    
DOI: 10.1016/j.jgyn.2011.09.022     Document Type: Article

References (104)

1. M.A. Lumsden, and E.M. Wallace Clinical presentation of uterine fibroids Baillieres Clin Obstet Gynaecol 12 1998 177 195 (Pubitemid 28456986)
2. J.L. Marino, B. Eskenazi, M. Warner, S. Samuels, P. Vercellini, and N. Gavoni Uterine leiomyoma and menstrual cycle characteristics in a population-based cohort study Hum Reprod 19 2004 2350 2355 (Pubitemid 39406700)
3. D.J. DeWaay, C.H. Syrop, I.E. Nygaard, W.A. Davis, and B.J. Van Voorhis Natural history of uterine polyps and leiomyomata Obstet Gynecol 100 2002 3 7 (Pubitemid 34722837)
4. G. Pron, M. Cohen, J. Soucie, G. Garvin, L. Vanderburgh, and S. Bell The ontario uterine fibroid embolization trial. Part 1. Baseline patient characteristics, fibroid burden, and impact on life Fertil Steril 79 2003 112 119 (Pubitemid 36071248)
5. C.R. Chen, G.M. Buck, N.G. Courey, K.M. Perez, and J. Wactawski-Wende Risk factors for uterine fibroids among women undergoing tubal sterilization Am J Epidemiol 153 2001 20 26 (Pubitemid 32041892)
6. C. Huchon, and X. Fritel Epidemiology of menometrorrhagia J Gynecol Obstet Biol Reprod 37 2008 S307 S316
7. S.J. Robboy, R.C. Bentley, K. Butnor, and M.C. Anderson Pathology and pathophysiology of uterine smooth-muscle tumors Environ Health Perspect 108 2000 779 784
8. A.F. Haney Clinical decision making regarding leiomyomata: what we need in the next millenium Environ Health Perspect 108 2000 835 839
9. K. Englund, A. Blanck, I. Gustavsson, U. Lundkvist, P. Sjoblom, and A. Norgren Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment J Clin Endocrinol Metab 83 1998 4092 4096 (Pubitemid 28513601)
10. F. Amant, E. Huys, A. Geurts-Moespot, B.G. Lindeque, I. Vergote, and F. Sweep Ethnic variations in uterine leiomyoma biology are not caused by differences in myometrial estrogen receptor alpha levels J Soc Gynecol Investig 10 2003 105 109 (Pubitemid 36184766)
11. D.S. Hunter, L.C. Hodges, P.K. Eagon, P.M. Vonier, R. Fuchs-Young, and J.S. Bergerson Influence of exogenous estrogen receptor ligands on uterine leiomyoma: evidence from an in vitro/in vivo animal model for uterine fibroids Environ Health Perspect 108 2000 829 834
12. B. Viville, D.S. Charnock-Jones, A.M. Sharkey, B. Wetzka, and S.K. Smith Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyomata and adjacent myometrium Hum Reprod 12 1997 815 822 (Pubitemid 27223053)
13. M.S. Rein Advances in uterine leiomyoma research: the progesterone hypothesis Environ Health Perspect 108 2000 791 793
14. Y. Shimomura, H. Matsuo, T. Samoto, and T. Maruo Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma J Clin Endocrinol Metab 83 1998 2192 2198 (Pubitemid 28496358)
15. E.A. Stewart Uterine fibroids Lancet 357 2001 293 298 (Pubitemid 32120866)
16. X. Wu, A. Blanck, M. Olovsson, B. Moller, and B. Lindblom Expression of basic fibroblast growth factor (bFGF), FGF receptor 1 and FGF receptor 2 in uterine leiomyomas and myometrium during the menstrual cycle, after menopause and GnRHa treatment Acta Obstet Gynecol Scand 80 2001 497 504 (Pubitemid 32521287)
17. M. Wolanska, and E. Bankowski Fibroblast growth factors (FGF) in human myometrium and uterine leiomyomas in various stages of tumour growth Biochimie 88 2006 141 146 (Pubitemid 41668604)
18. A. Arici, and I. Sozen Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma Am J Obstet Gynecol 188 2003 76 83 (Pubitemid 36135601)
19. W.K. Baek, D. Kim, N. Jung, Y.W. Yi, J.M. Kim, and S.D. Cha Increased expression of cyclin G1 in leiomyoma compared with normal myometrium Am J Obstet Gynecol 188 2003 634 639 (Pubitemid 36332426)
20. S.H. Kwon, J.C. Park, S. Ramachandran, S.D. Cha, K.Y. Kwon, and J.K. Park Loss of cyclin g1 expression in human uterine leiomyoma cells induces apoptosis Reprod Sci 15 2008 400 410 (Pubitemid 351697334)
21. T. Kobayashi, and J. Sugiura The effect of a new potent antifibrinolytic agent, tranexamic acid J Jpn Obstet Gynecol Soc 13 1966 158 167
22. J. Bonnar, and B.L. Sheppard Treatment of menorrhagia during menstruation: randomised controlled trial of ethamsylate, mefenamic acid, and tranexamic acid BMJ 313 1996 579 582 (Pubitemid 26293640)
23. K.P. Lakhani, M.S. Marsh, W. Purcell, and P. Hardiman Uterine artery blood flow parameters in women with dysfunctional uterine bleeding and uterine fibroids: the effects of tranexamic acid Ultrasound Obstet Gynecol 11 1998 283 285 (Pubitemid 28242876)
24. P.P. Ip, K.W. Lam, C.L. Cheung, M.C. Yeung, T.C. Pun, and Q.K. Chan Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas Am J Surg Pathol 31 2007 1215 1224 (Pubitemid 47207126)
25. W.T. Mixson, and D.O. Hammond Response of fibromyomas to a progestin Am J Obstet Gynecol 82 1961 754 760
26. P. Lumbiganon, S. Rugpao, S. Phandhu-fung, M. Laopaiboon, N. Vudhikamraksa, and Y. Werawatakul Protective effect of depot-medroxyprogesterone acetate on surgically treated uterine leiomyomas: a multicentre case - control study Br J Obstet Gynaecol 103 1996 909 914 (Pubitemid 26297917)
27. N. Johnson, H. Fletcher, and M. Reid Depo medroxyprogesterone acetate (DMPA) therapy for uterine myomata prior to surgery Int J Gynaecol Obstet 85 2004 174 176 (Pubitemid 38510237)
28. S. Venkatachalam, J.S. Bagratee, and J. Moodley Medical management of uterine fibroids with medroxyprogesterone acetate (Depo-Provera): a pilot study J Obstet Gynaecol 24 2004 798 800 (Pubitemid 39643463)
29. R. Sitruk-Ware Progestins and cardiovascular risk markers Steroids 65 2000 651 658
30. E. Verspyck, L. Marpeau, and C. Lucas Leuprorelin depot 3.75 mg versus lynestrenol in the preoperative treatment of symptomatic uterine myomas: a multicentre randomised trial Eur J Obstet Gynecol Reprod Biol 89 2000 7 13 (Pubitemid 30103776)
31. L.C. Hodges, K.D. Houston, D.S. Hunter, R. Fuchs-Young, Z. Zhang, and R.C. Wineker Transdominant suppression of estrogen receptor signaling by progesterone receptor ligands in uterine leiomyoma cells Mol Cell Endocrinol 196 2002 11 20 (Pubitemid 35254102)
32. H. Rozenbaum Traitement médical des fibromes utérins par les progestatifs de synthse du groupe norprégnane Gynécologie 40 1989 175 179 (Pubitemid 19153043)
33. A. Audebert, and C. Denis Utilisation de la promegestone dans le traitement des fibromyomes compliqués de ménométrorragies. Bilan d'une étude multicentrique Gynécologie 40 1989 23 26 (Pubitemid 19094554)
34. H. Rozenbaum Traitement médical des fibromes utérins par un progestatif de synthse du groupe norprégnane Contracept Fertil Sex 17 1989 153 156 (Pubitemid 19061022)
35. E. Amadio Traitement médical des fibromyomes utérins par le nomégestrol acétate Abstract Gynecol 69 1991 1 14
36. A. Lethaby, B. Vollenhoven, and M. Sowter Efficacy of pre-operative gonadotrophin hormone releasing analogues for women with uterine fibroids undergoing hysterectomy or myomectomy: a systematic review BJOG 109 2002 1097 1108 (Pubitemid 35287078)
37. O. Ortmann, and K. Diedrich Pituitary and extrapituitary actions of gonadotrophin-releasing hormone and its analogues Hum Reprod 14 1999 194 206 (Pubitemid 29488151)
38. F.J. Broekmans GnRH agonists and uterine leiomyomas Hum Reprod 11 1996 3 25 (Pubitemid 28310529)
39. A. Stewart, C. Cummins, L. Gold, R. Jordan, and W. Phillips The effectiveness of the levonorgestrel-releasing intrauterine system in menorrhagia: a systematic review BJOG 108 2001 74 86 (Pubitemid 32102607)
40. D. Wildemeersch, and E. Schacht The effect on menstrual blood loss in women with uterine fibroids of a novel "frameless" intrauterine levonorgestrel-releasing drug delivery system: a pilot study Eur J Obstet Gynecol Reprod Biol 102 2002 74 79 (Pubitemid 34224081)
41. F. Mercorio, R. De Simone, A. Di Spiezio Sardo, G. Cerrota, G. Bifulco, and F. Vanacore The effect of a levonorgestrel-releasing intrauterine device in the treatment of myoma-related menorrhagia Contraception 67 2003 277 280 (Pubitemid 36398511)
42. V. Grigorieva, M. Chen-Mok, M. Tarasova, and A. Mikhailov Use of a levonorgestrel-releasing intrauterine system to treat bleeding related to uterine leiomyomas Fertil Steril 79 2003 1194 1198 (Pubitemid 36547859)
43. H.F. Rizkalla, M. Higgins, P. Kelehan, and C. O'Herlihy Pathological findings associated with the presence of a mirena intrauterine system at hysterectomy Int J Gynecol Pathol 27 2008 74 78 (Pubitemid 351627977)
44. S. Rintala, E. Kujansuu, K. Teisala, I. Rantala, S. Kivinen, and R. Tuimala GnRH analogues and uterine leiomyomas. Effect of hormone replacement therapy on cell proliferation Gynecol Obstet Invest 48 1999 276 279
45. H. Nakayama, T. Yano, Y. Sagara, A. Kikuchi, K. Ando, and Y. Wang Estriol add-back therapy in the long-acting gonadotropin-releasing hormone agonist treatment of uterine leiomyomata Gynecol Endocrinol 13 1999 382 389 (Pubitemid 30068311)
46. A. Gömen, I.H. Kara, and M. Karaca The effects of add-back therapy with tibolone on myoma uteri Clin Exp Obstet Gynecol 29 2002 222 224 (Pubitemid 36004706)
47. S. Palomba, M. Pellicano, P. Affinito, C. Di Carlo, F. Zullo, and C. Nappi Effectiveness of short-term administration of tibolone plus gonadotropin-releasing hormone analogue on the surgical outcome of laparoscopic myomectomy Fertil Steril 75 2001 429 433 (Pubitemid 32112126)
48. S. Palomba, F. Orio Jr., A. Falbo, R. Oppedisano, A. Tolino, and F. Zullo Tibolone reverses the cognitive effects caused by leuprolide acetate administration, improving mood and quality of life in patients with symptomatic uterine leiomyomas Fertil Steril 90 2008 165 173 (Pubitemid 351885184)
49. A. Di Lieto, M. De Falco, G. Mansueto, G. De Rosa, F. Pollio, and S. Staibano Preoperative administration of GnRH-a plus tibolone to premenopausal women with uterine fibroids: evaluation of the clinical response, the immunohistochemical expression of PDGF, bFGF and VEGF and the vascular pattern Steroids 70 2005 95 102 (Pubitemid 41556688)
50. A.J. Friedman, R.L. Barbieri, P.M. Doubilet, C. Fine, and I. Schiff A randomized, double-blind trial of a gonadotropin releasing-hormone agonist (leuprolide) with or without medroxyprogesterone acetate in the treatment of leiomyomata uteri Fertil Steril 49 1988 404 409 (Pubitemid 18063993)
51. C.P. West, M.A. Lumsden, H. Hillier, V. Sweeting, and D.T. Baird Potential role for medroxyprogesterone acetate as an adjunct to goserelin (Zoladex) in the medical management of uterine fibroids Hum Reprod 7 1992 328 332
52. L.E. Caird, C.P. West, M.A. Lumsden, W.J. Hannan, and S.M. Gow Medroxyprogesterone acetate with Zoladex for long-term treatment of fibroids: effects on bone density and patient acceptability Hum Reprod 12 1997 436 440 (Pubitemid 27156431)
53. Wu T, Chen X, Xie L. Selective estrogen receptor modulators (SERMs) for uterine leiomyomas. Cochrane Database Syst Rev 2007:CD005287.
54. S. Palomba, T. Russo, F. Orio Jr., L. Tauchmanova, E. Zupi, and P.L. Panici Effectiveness of combined GnRH analogue plus raloxifene administration in the treatment of uterine leiomyomas: a prospective, randomized, single-blind, placebo-controlled clinical trial Hum Reprod 17 2002 3213 3219 (Pubitemid 35469276)
55. R.E. Felberbaum, W. Kupker, and K. Diedrich Will GnRH antagonists assist in the treatment of benign gynaecological diseases? Reprod Biomed Online 5 2002 68 72
56. R.E. Felberbaum, W. Kupker, M. Krapp, B. Gehl, M. Ludwig, and K. Diedrich Preoperative reduction of uterine fibroids in only 16 days by administration of a gonadotrophin-releasing hormone antagonist (cetrotide) Reprod Biomed Online 3 2001 14 18
57. D. Gonzalez-Barcena, R.B. Alvarez, E.P. Ochoa, I.C. Cornejo, A.M. Comaru-Schally, and A.V. Schally Treatment of uterine leiomyomas with luteinizing hormone-releasing hormone antagonist cetrorelix Hum Reprod 12 1997 2028 2035 (Pubitemid 27462487)
58. J.B. Engel, A. Audebert, R. Frydman, J. Zivny, and K. Diedrich Presurgical short term treatment of uterine fibroids with different doses of cetrorelix acetate: a double-blind, placebo-controlled multicenter study Eur J Obstet Gynecol Reprod Biol 134 2007 225 232 (Pubitemid 47470003)
59. Ke LQ, Yang K, Li J, Li CM. Danazol for uterine fibroids. Cochrane Database Syst Rev 2009:CD007692.
60. J. Zhang Short-term effects of danazol for uterine fibroids Med Guangdong 19 1998 463 464
61. A. DeCherney, R. Maheux, and M. Polan A medical treatment for myomata uteri Fertil Steril 39 1983 429 430
62. X. Peng, and A. Wei Treatment of uterine leiomyoma with danazol or mifepristone Pract Clin Med 3 2002 105 106
63. M. Ueki, Y. Okamoto, T. Tsurunaga, Y. Seiki, M. Ueda, and O. Sugimoto Endocrinological and histological changes after treatment of uterine leiomyomas with danazol or buserelin J Obstet Gynaecol (Tokyo 1995) 21 1995 1 7
64. O. Triolo, A. De Vivo, V. Benedetto, S. Falcone, and F. Antico Gestrinone versus danazol as preoperative treatment for hysteroscopic surgery: a prospective, randomized evaluation Fertil Steril 85 2006 1027 1031
65. A. La Marca, S. Giulini, G. Vito, R. Orvieto, A. Volpe, and V.M. Jasonni Gestrinone in the treatment of uterine leiomyomata: effects on uterine blood supply Fertil Steril 82 2004 1694 2166
66. O. Sadan, S. Ginath, D. Sofer, S. Rotmensch, A. Debby, and M. Glezerman The role of tamoxifen in the treatment of symptomatic uterine leiomyomata - a pilot study Eur J Obstet Gynecol Reprod Biol 96 2001 183 186 (Pubitemid 32522557)
67. V. Doridot, P. This, and K.B. Clough Explosive growth of uterine leiomyomas and carcinologic ovarian risk in a non-menopausal patient with BRCA1-BRCA2 mutation treated by tamoxifen J Gynecol Obstet Biol Reprod (Paris) 31 2002 677 680 (Pubitemid 35407975)
68. S. Palomba, F. Orio Jr., M. Morelli, T. Russo, M. Pellicano, and E. Zupi Raloxifene administration in premenopausal women with uterine leiomyomas: a pilot study J Clin Endocrinol Metab 87 2002 3603 3608 (Pubitemid 34879502)
69. S. Jirecek, A. Lee, I. Pavo, G. Crans, W. Eppel, and R. Wenzl Raloxifene prevents the growth of uterine leiomyomas in premenopausal women Fertil Steril 81 2004 132 136 (Pubitemid 38058338)
70. J. Donnez, B. Hervais Vivancos, M. Kudela, A. Audebert, and P. Jadoul A randomized, placebo-controlled, dose-ranging trial comparing fulvestrant with goserelin in premenopausal patients with uterine fibroids awaiting hysterectomy Fertil Steril 79 2003 1380 1389 (Pubitemid 36687885)
71. T. Yamamoto, K. Takamori, and H. Okada Effect of aminoglutethimide on androstenedione aromatase activity in human uterine leiomyoma Horm Metab Res 17 1985 548 549 (Pubitemid 16245529)
72. M. Shozu, K. Murakami, T. Segawa, T. Kasai, and M. Inoue Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a non-steroidal aromatase inhibitor Fertil Steril 79 2003 628 631 (Pubitemid 36293465)
73. F.K. Varelas, A.N. Papanicolaou, N. Vavatsi-Christaki, G.A. Makedos, and G.D. Vlassis The effect of anastrazole on symptomatic uterine leiomyomata Obstet Gynecol 110 2007 643 649 (Pubitemid 47359590)
74. S.G. Hilario, N. Bozzini, R. Borsari, and E.C. Baracat Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients Fertil Steril 91 2009 240 243
75. B. Gurates, C. Parmaksiz, G. Kilic, H. Celik, S. Kumru, and M. Simsek Treatment of symptomatic uterine leiomyoma with letrozole Reprod Biomed Online 17 2008 569 574
76. M.E. Parsanezhad, M. Azmoon, S. Alborzi, A. Rajaeefard, A. Zarei, and T. Kazerooni A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status Fertil Steril 93 2010 192 198
77. J. Steinauer, E.A. Pritts, R. Jackson, and A.F. Jacoby Systematic review of mifepristone for the treatment of uterine leiomyomata Obstet Gynecol 103 2004 1331 1336 (Pubitemid 40458970)
78. M. Engman, S. Granberg, A.R. Williams, C.X. Meng, P.G. Lalitkumar, and K. Gemzell-Danielsson Mifepristone for treatment of uterine leiomyoma. A prospective randomized placebo controlled trial Hum Reprod 24 2009 1870 1879
79. C. Feng, S. Meldrum, and K. Fiscella Improved quality of life is partly explained by fewer symptoms after treatment of fibroids with mifepristone Int J Gynaecol Obstet 109 2010 121 124
80. M. Bagaria, A. Suneja, N.B. Vaid, K. Guleria, and K. Mishra Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trial Aust N Z J Obstet Gynaecol 49 2009 77 83
81. K. Fiscella, S.H. Eisinger, S. Meldrum, C. Feng, S.G. Fisher, and D.S. Guzick Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: a randomized controlled trial Obstet Gynecol 108 2006 1381 1387 (Pubitemid 44901011)
82. J.L. Carbonell Esteve, R. Acosta, B. Heredia, Y. Perez, M.C. Castaneda, and A.V. Hernandez Mifepristone for the treatment of uterine leiomyomas: a randomized controlled trial Obstet Gynecol 112 2008 1029 1036
83. N. Chabbert-Buffet, G. Meduri, P. Bouchard, and I.M. Spitz Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications Hum Reprod Update 11 2005 293 307 (Pubitemid 40674206)
84. A.R. Williams, H.O. Critchley, J. Osei, S. Ingamells, I.T. Cameron, and C. Han The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata Hum Reprod 22 2007 1696 1704 (Pubitemid 47061342)
85. K. Chwalisz, L. Larsen, C. Mattia-Goldberg, A. Edmonds, W. Elger, and C.A. Winkel A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata Fertil Steril 87 2007 1399 1412 (Pubitemid 46829155)
86. J. Wilkens, K. Chwalisz, C. Han, J. Walker, I.T. Cameron, and S. Ingamells Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy J Clin Endocrinol Metab 93 2008 4664 4671
87. L.K. Nieman, W. Blocker, T. Nansel, S. Mahoney, J. Reynolds, and D. Blithe Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study Fertil Steril 95 2011 767-72e1-2
88. E.D. Levens, C. Potlog-Nahari, A.Y. Armstrong, R. Wesley, A. Premkumar, and D.L. Blithe CDB-2914 for uterine leiomyomata treatment: a randomized controlled trial Obstet Gynecol 111 2008 1129 1136 (Pubitemid 351620347)
89. R.A. Nowak Identification of new therapies for leiomyomas: what in vitro studies can tell us Clin Obstet Gynecol 44 2001 327 334 (Pubitemid 32374434)
90. K. Minakuchi, N. Kawamura, A. Tsujimura, and S. Ogita Remarkable and persistent shrinkage of uterine leiomyoma associated with interferon alfa treatment for hepatitis Lancet 353 1999 2127 2128 (Pubitemid 29278487)
91. B.S. Lee, S.B. Margolin, and R.A. Nowak Pirfenidone: a novel pharmacological agent that inhibits leiomyoma cell proliferation and collagen production J Clin Endocrinol Metab 83 1998 219 223 (Pubitemid 28498339)
92. R.K. Ross, M.C. Pike, M.P. Vessey, D. Bull, D. Yeates, and J.T. Casagrande Risk factors for uterine fibroids: reduced risk associated with oral contraceptives Br Med J (Clin Res Ed) 293 1986 359 362 (Pubitemid 16034122)
93. R.L. Barbieri Reduction in the size of a uterine leiomyoma following discontinuation of an estrogen-progestin contraceptive Gynecol Obstet Invest 43 1997 276 277 (Pubitemid 27249958)
94. L.M. Marshall, D. Spiegelman, M.B. Goldman, J.E. Manson, G.A. Colditz, and R.L. Barbieri A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata Fertil Steril 70 1998 432 439 (Pubitemid 28435626)
95. C. Jamin Contraception, hormone replacement therapy and myomas J Gynecol Obstet Biol Reprod (Paris) 28 1999 768 771 (Pubitemid 30026274)
96. F. Chiaffarino, F. Parazzini, C. La Vecchia, S. Marsico, M. Surace, and E. Ricci Use of oral contraceptives and uterine fibroids: results from a case-control study Br J Obstet Gynaecol 106 1999 857 860 (Pubitemid 29361214)
97. A.B. Sener, N.C. Seckin, S. Ozmen, O. Gokmen, N. Dogu, and E. Ekici The effects of hormone replacement therapy on uterine fibroids in postmenopausal women Fertil Steril 65 1996 354 357 (Pubitemid 26043832)
98. P. Ylostalo, S. Granberg, A.C. Backstrom, and T. Hirsjarvi-Lahti Uterine findings by transvaginal sonography during percutaneous estrogen treatment in postmenopausal women Maturitas 23 1996 313 317 (Pubitemid 26000613)
99. F. Polatti, F. Viazzo, R. Colleoni, and R.E. Nappi Uterine myoma in postmenopause: a comparison between two therapeutic schedules of HRT Maturitas 37 2000 27 32
100. S. Palomba, T. Sena, R. Noia, C. Di Carlo, F. Zullo, and P. Mastrantonio Transdermal hormone replacement therapy in postmenopausal women with uterine leiomyomas Obstet Gynecol 98 2001 1053 1058 (Pubitemid 34075330)
101. S. Palomba, T. Sena, M. Morelli, R. Noia, F. Zullo, and P. Mastrantonio Effect of different doses of progestin on uterine leiomyomas in postmenopausal women Eur J Obstet Gynecol Reprod Biol 102 2002 199 201 (Pubitemid 34272730)
102. N. Colacurci, P. De Franciscis, L. Cobellis, G. Nazzaro, and G. De Placido Effects of hormone replacement therapy on postmenopausal uterine myoma Maturitas 35 2000 167 173 (Pubitemid 30642834)
103. M. Wahab, J. Thompson, and F. Al-Azzawi The effect of submucous fibroids on the dose-dependent modulation of uterine bleeding by trimegestone in postmenopausal women treated with hormone replacement therapy BJOG 107 2000 329 334 (Pubitemid 30145373)
104. I.S. Fraser, G. McCarron, R. Markham, T. Resta, and A. Watts Measured menstrual blood loss in women with menorrhagia associated with pelvic disease or coagulation disorder Obstet Gynecol 68 1986 630 633 (Pubitemid 16005573)