Increased expression of cyclin G1 in leiomyoma compared with normal myometrium

American Journal of Obstetrics and Gynecology

Volumn 188, Issue 3, 2003, Pages 634-639

  Baek, Won Ki ^a   Kim, Daegun ^b   Jung, Neoncheol ^c   Yi, Yong Weon ^c   Kim, Jin Man ^d   Cha, Soon Do ^a   Bae, Insoo ^e   Cho, Chi Heum ^a  

^a Keimyung University   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c Neurogenex Inc   (South Korea)

^d Chungnam National University   (South Korea)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Cyclin G1; Uterine leiomyoma

Indexed keywords

CYCLIN A; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYCLIN G1; CYCLINE; MESSENGER RNA; PROTEIN P53; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LEIOMYOMA; MYOMETRIUM; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

EID: 0037341295     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2003.140     Document Type: Article

References (25)

1. Buttram VC Jr, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril 1981;36:433-45.
2. Carlson KJ, Nichols DH, Schiff I. Indications for hysterectomy. N Engl J Med 1993;328:856-60.
3. Baird DT, Bramley TA, Hawkins TA, Lumsden MA, West CP. Effect of treatment with LHRH analogue Zoladex on binding of oestradiol, progesterone and epidermal growth factor to uterine fibromyomata. Horm Res 1989;32:154-6.
4. Hunter T, Pines J. Cyclins and cancer. Cell 1991;66:1071-4.
5. Pines J, Hunter T. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cydin B. Nature 1990;846:760-3.
6. Jiang W, Kahn SM, Tomita N, Zhang YJ, Lu SH, Weinstein IB. Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res 1992;52:2980-3.
7. Weinstat-Saslow D, Merino MJ, Manrow RE, Lawrence JA, Bluth RF, Wittenbel KD, et al. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nat Med 1995;1:1257-60.
8. Tamaru T, Trigun SK, Okada M, Nakagawa H. Identification of cells expressing a D type G1 cyclin in matured brain: implication for its role in neuronal function. Neurosci Lett 1993;153:169-72.
9. Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubauer M, Wahl AF. Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. J Biol Chem 1996;271:6050-61.
10. Tamura K, Kanaoka Y, Jinno S, Nagata A, Ogiso Y, Shimizu K, et al. Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. Oncogene 1993;8:2113-8.
11. Kanaoka Y, Kimura SH, Okazaki I, Ikeda M, Nojima H. GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. FEBS Lett 1997;402:73-80.
12. Okamoto K, Kamibayashi C, Serrano M, Prives C, Mumby MC, Beach D. p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol Cell Biol 1996;16:6593-602.
13. Okamoto K, Beach D. Cyclin G is a transcriptional target ot the p53 tumor suppressor protein. EMBO J 1994;13:4816-22.
14. Zauberman A, Lupo A, Oren M. Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites. Oncogene 1995;10:2361-6.
15. Smith ML, Kontny HU, Bortnick R, Fornace AJ Jr. The p53-regulated cyclin G gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity. Exp Cell Res 1997;230:61-8.
16. Skotzko M, Wu L, Anderson WF, Gordon EM, Hall FL. Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells. Cancer Res 1995;55:5493-8.
17. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
18. Blin N, Stafford DW. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res 1976;3:2303-8.
19. de Vos S, Wilczynski SP, Fleischhacker M, Koeffler P. p53 alterations in uterine leiomyosarcomas versus leiomyomas. Gynecol Oncol 1994;54:205-8.
20. Zhai YL, Nikaido T, Shiozawa T, Orii A, Fujii S. Expression of cyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus. Int J Cancer 1999;84:244-50.
21. Hall KL, Teneriello MG, Taylor RR, Lemon S, Ebina M, Linnoila RI, et al. Analysis of Ki-ras, p53, and MDM2 genes in uterine leiomyomas and leiomyosarcomas. Gynecol Oncol 1997;65:330-5.
22. Brandon DD, Erickson TE, Keenan EJ, Strawn EY, Novy MJ, Burry KA, et al. Estrogen receptor gene expression in human uterine leiomyomata. J Clin Endocrinol Metab 1995;80:1876-81.
23. Brandon DD, Bethea CL, Strawn EY, Now MJ, Burry KA, Harrington MS, et al. Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas. Am J Obstet Gynecol 1993;169:78-85.
24. Reimer CL, Borras AM, Kurdistani SK, Garreau JR, Chung M, Aaronson SA, et al. Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. J Biol Chem 1999;274:11022-9.
25. Smith ML, Bortnick RA, Sheikh MS, Fornace AJ Jr. Chromatin relaxation by overexpression of 1. mutant p53, HPV1.6-E6, or cyclin G transgenes. Exp Cell Res 1998;242:235-43.