The effect of submucous fibroids on the dose-dependent modulation of uterine bleeding by trimegestone in postmenopausal women treated with hormone replacement therapy

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 107, Issue 3, 2000, Pages 329-334

  Wahab, May ^a   Thompson, John ^a   Al Azzawi, Farook ^a  

^a LEICESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; GESTAGEN; PREGNANE DERIVATIVE; PROGESTERONE DERIVATIVE; RU 3499; TRIMEGESTONE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; ENDOMETRIUM BIOPSY; FEMALE; HORMONE SUBSTITUTION; HUMAN; HUMAN TISSUE; HYSTEROSCOPY; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; UNITED KINGDOM; UTERUS BLEEDING; UTERUS MYOMA;

DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOMETRIUM; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; LEIOMYOMA; MIDDLE AGED; POSTMENOPAUSE; PROGESTERONE CONGENERS; PROMEGESTONE; UTERINE HEMORRHAGE; UTERINE NEOPLASMS;

EID: 0034014932     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2000.tb13227.x     Document Type: Article

References (19)

1. Al-Azzawi F, Habiba M. Regular bleeding on hormone replacement therapy: a myth Br J Obstet Gynaecol 1994; 101: 661–662.
2. Nachtigall LE. Enhancing patient compliance with hormone replacement therapy at menopause. Enhancing patient compliance with hormone replacement therapy at menopause 1990; 75 (Suppl): 77–80.
3. Daly E, Vessey MP, Barlow D, Gray A, McPherson K, Roche M. Hormone replacement therapy in a risk-benefit perspective Maturitas 1996; 23: 247–259.
4. Akkad A, Hartshorne T, Bell PRF, Al-Azzawi F. Carotid plaque regression on oestrogen replacement: a pilot study. Euro J Vas Endo Surgery. 1996; 11: 347–348.
5. Paganini HA, Henderson VW. Estrogen replacement therapy and risk of Alzheimer disease. Arch Intern Med 1996; 156: 2213–2217.
6. Itzkowic D. Submucous myoma: Clinical profile and hysteroscopic management. Aust NZ J Obstet Gynecol 1993; 33: 63–67.
7. Downes E, Al-Azzawi F. The predictive value of outpatient hysteroscopy in a menopause clinic. Br J Obstet Gynaecol 1993; 100: 1148–1149.
8. Nagele F, O'Connor H, Baskett TF, Davies A, Mohammed H, Magos AL. Hysteroscopy in women with abnormal uterine bleeding on hormone replacement therapy: a comparison with postmenopausal bleeding. Fertil Steril 1996; 65: 1145–1150.
9. Akkad AA, Habiba MA, Ismail N, Abrams K, Al-Azzawi F. Abnormal uterine bleeding on hormone replacement: the importance of intrauterine structural abnormalities. Obstet Gynecol 1995; 86: 330–334.
10. MacKenzie JZ, Bibby JG. Critical assessment of dilatation and curettage in 1029 women. Lancet 1978; ii: 566–569.
11. Philibert D, Bouchoux F, Degryse M et al. The pharmacological profile of a novel norpregnane progestin (trimegestone). Gynecol Endocrinol 1999; 13: 316–326.
12. Al-Azzawi F, Wahab M, Thompson J, Whitehead M, Thompson W. Acceptability and patterns of uterine bleeding in sequential trimegestone-based hormone replacement therapy: a dose-ranging study. Hum Reprod 1999; 14: 636–641.
13. Patterson HD, Thompson R. Recovery of inter-block information when block sizes are unequal. Biometrika 1971; 58: 545–554.
14. Brestlow NE, Clayton DO. Approximate inference in generalised linear mixed models. JAm Stat Ass 1993; 88: 9–25. Gynecol 1996 8: 250–256.
15. GENSTAT 5 Committee. GENSTAT 5 Release 3 Reference Manual. Oxford: Clarendon Press, 1993.
16. Sampson JA. The blood supply of uterine myomata. Surg Gynaecol Obstet 1912; 14: 215–230.
17. Farrer-Brown G, Beilby JOW, Tarbit MH. Venous changes in the endometrium of myomatous uteri. Obstet Gynecol 1971; 38: 741–751.
18. Hallez JP. Myomectomies by endo-uterine resection. Curr Opin Obstet Gynecol 1996; 8: 250–256.
19. Sturdee DW, Wade-Evans T, Paterson MEL, Studd JWW. Relations between bleeding pattern, endometrial histology, and oestrogen treatment in menopausal women. BMJ 1978; 1: 1575–1577.