Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia

Cancer Chemotherapy and Pharmacology

Volumn 68, Issue 5, 2011, Pages 1155-1159

  Albayrak, Meryem ^a,b   Konyssova, Uljan ^a   Kaya, Zuhre ^a   Gursel, Turkiz ^a   Guntekin, Sezen ^a   Percin, E Ferda ^a   Kocak, Ulker ^a  

^a GAZI UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Children; Leukemia; Mercaptopurine; Thiopurine methyltransferase polymorphisms

Indexed keywords

MERCAPTOPURINE; METHOTREXATE; THIOPURINE METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; ARTICLE; BONE MARROW TOXICITY; CHILD; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME POLYMORPHISM; FEMALE; GENE; GENE FREQUENCY; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HUMAN; INFECTION; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; PHARMACOGENETICS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; THIOPURINE METHYLTRANSFERASE GENE; TURKEY (REPUBLIC);

EID: 82455171912     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-011-1599-7     Document Type: Article

References (32)

1. RM Weinshilboum SL Sladek 1980 Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity Am J Hum Genet 32 651 662 7191632 1:CAS:528:DyaL3cXmtFyltbw%3D (Pubitemid 10061685)
2. S Zhou 2006 Clinical pharmacogenomics of thiopurine S-methyltransferase Curr Clin Pharmacol 1 119 128 18666383 1:CAS:528:DC%2BD28XitFOnsro%3D
3. R Pieters WL Carroll 2010 Biology and treatment of acute lymphoblastic leukemia Hematol Oncol Clin N Am 24 1 18 10.1016/j.hoc.2009.11.014
4. HL McLeod JS Lin EP Scott CH Pui WE Evans 1994 Thiopurine methyltransferase activity in American white subjects and black subjects Clin Pharmacol Ther 55 15 20 8299312 10.1038/clpt.1994.4 1:CAS:528:DyaK2cXjt1SjsLo%3D (Pubitemid 24062187)
5. CR Yates EY Krynetski T Loennechen MY Fessing HL Tai CH Pui MV Relling WE Evans 1997 Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathiopurine and mercaptopurine intolerance Ann Intern Med 126 608 614 9103127 1:CAS:528:DyaK2sXivFehur8%3D (Pubitemid 27172187)
6. JE Higgs K Payne C Roberts WG Newman 2010 Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications Pharmacogenomics 11 177 188 20136357 10.2217/pgs.09.155 1:CAS:528:DC%2BC3cXhsFGitb8%3D
7. MV Relling ML Hancock GK Rivera JT Sandlund RC Ribeiro EY Krynetski CH Pui WE Evans 1999 Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus J Natl Cancer Inst 91 2001 2008 10580024 10.1093/jnci/91.23.2001 1:CAS:528:DC%2BD3cXktl2i
8. S Ujiie T Sasaki M Mizugaki M Ishikawa M Hiratsuka 2008 Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2-*24) Pharmacogenet Genomics 18 887 893 18708949 10.1097/FPC.0b013e3283097328 1:CAS:528:DC%2BD1cXhtFartbjK
9. K Rutherford V Daggett 2008 Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics J Mol Biol 379 803 814 18482735 10.1016/j.jmb.2008.04.032 1:CAS:528:DC%2BD1cXmsFKqsL8%3D
10. WE Evans 2002 Comprehensive assessment of thiopurine S-methyltransferase (TPMT) alleles in three ethnic populations J Pediatr Hematol Oncol 24 335 336 12142779 10.1097/00043426-200206000-00002 (Pubitemid 34774001)
11. C Ganiere-Monteil Y Medard C Lejus B Bruneau A Pineau O Fenneteau M Bourin E Jacqz-Aigrain 2004 Phenotype, genotype for thiopurine methyltransferase activity in the French Caucasian population: impact of age Eur J Clin Pharmacol 60 89 96 15022030 10.1007/s00228-004-0732-5 1:CAS:528:DC%2BD2cXjtFyit7s%3D (Pubitemid 38626437)
12. L Serpe PL Calvo E Muntoni S D'Antico M Giaccone A Avagnina M Baldi C Barbera F Curti A Pera, et al. 2009 Thiopurine S-methyltransferase pharmacogenetics in a large-scale healthy Italian-Caucasian population: differences in enzyme activity Pharmacogenomics 10 1753 1765 19891552 10.2217/pgs.09.103 1:CAS:528:DC%2BD1MXhtlOiu77I
13. JP Gisbert F Gomollon C Cara M Luna Y Gonzalez-Lama JM Pajares J Mate LG Guijarro 2007 Thiopurine methyltransferase activity in Spain: a study of 14,545 patients Dig Dis Sci 52 1262 1269 17334911 10.1007/s10620-006-9119-z 1:CAS:528:DC%2BD2sXktlWisbY%3D (Pubitemid 46626159)
14. L Dokmanovic J Urosevic D Janic N Jovanovic B Petrucev N Tosic S Pavlovic 2006 Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia Ther Drug Monit 28 800 806 17164697 10.1097/01.ftd. 0000249947.17676.92 1:CAS:528:DC%2BD28XhtlSrs7fL (Pubitemid 44967661)
15. E Efrati L Adler N Krivoy E Sprecher 2009 Distribution of TPMT risk alleles for thiopurine [correction of thioupurine] toxicity in the Israeli population Eur J Clin Pharmacol 65 257 262 19048244 10.1007/s00228-008-0590-7 1:CAS:528:DC%2BD1MXitVyiu7o%3D
16. SK Kham CK Soh TC Liu YH Chan H Ariffin PL Tan AE Yeoh 2008 Thiopurine S-methyltransferase activity in three major Asian populations: a population-based study in Singapore Eur J Clin Pharmacol 64 373 379 18193212 10.1007/s00228-007-0426-x 1:CAS:528:DC%2BD1cXisFCmtrY%3D
17. EV Samochatova NV Chupova A Rudneva O Makarova TV Nasedkina OE Fedorova AS Glotov Z Kozhekbaeva OA Maiorova AG Roumyantsev, et al. 2009 TPMT genetic variations in populations of the Russian Federation Pediatr Blood Cancer 52 203 208 19034904 10.1002/pbc.21837
18. M Ando Y Ando Y Hasegawa Y Sekido K Shimokata K Horibe 2001 Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukemia Pharmacogenetics 11 269 273 11337943 10.1097/00008571-200104000-00011 1:CAS:528:DC%2BD3MXjs1Sqsro%3D (Pubitemid 32319877)
19. G Kapoor A Maitra S Brahmachari V Brahmachari 2009 Application of SNaPshot for analysis of thiopurine methyltransferase gene polymorphisms Indian J Med Res 129 500 505 19675376 1:CAS:528:DC%2BD1MXpvV2hu78%3D
20. MM Ameyaw ES Collie-Duguid RH Powrie D Ofori-Adjei HL McLeod 1999 Thiopurine methyltransferase alleles in British and Ghanaian populations Hum Mol Genet 8 367 370 9931345 10.1093/hmg/8.2.367 1:CAS:528:DyaK1MXht12ksbo%3D (Pubitemid 29054280)
21. Z Kaya T Gursel SA Bakkaloglu U Kocak T Atasever SO Oktar 2007 Evaluation of renal function in Turkish children receiving BFM-95 therapy for acute lymphoblastic leukemia Pediatr Hematol Oncol 24 257 267 17613868 10.1080/08880010701441286 (Pubitemid 47026965)
22. TB Tumer G Ulusoy O Adali G Sahin S Gozdasoglu E Arinc 2007 The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia Am J Hematol 82 906 910 17617792 10.1002/ajh.20947 1:CAS:528:DC%2BD2sXht1ahtbrP (Pubitemid 47502696)
23. AO Ada HS Suzen M Iscan 2007 Polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1 in a male Turkish population Int J Toxicol 26 41 46 17365145 10.1080/10915810601118222 1:CAS:528: DC%2BD2sXktl2ltL8%3D (Pubitemid 46360921)
24. M Aydin O Hatirnaz N Erensoy U Ozbek 2005 CYP2D6 and CYP1A1 mutations in the Turkish population Cell Biochem Funct 23 133 135 15648054 10.1002/cbf.1222 1:CAS:528:DC%2BD2MXitl2ltr8%3D (Pubitemid 40363685)
25. L Lennard JC Welch JS Lilleyman 1997 Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity Br J Clin Pharmacol 44 455 461 9384462 10.1046/j.1365-2125.1997.t01-1-00607.x 1:CAS:528:DyaK2sXnsFansrg%3D (Pubitemid 27485476)
26. M Stanulla E Schaeffeler T Flohr G Cario A Schrauder M Zimmermann K Welte WD Ludwig CR Bartram UM Zanger M Eichelbaum M Schrappe M Schwab 2005 Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia JAMA 293 1485 1489 15784872 10.1001/jama.293.12.1485 1:CAS:528:DC%2BD2MXis1Crsbk%3D (Pubitemid 40393293)
27. CH Pui MV Relling WE Evans 2002 Role of pharmacogenomics and pharmacodynamics in the treatment of acute lymphoblastic leukaemia Best Pract Res Clin Haematol 15 741 756 12617874 10.1053/beha.2002.0225 1:CAS:528:DC%2BD3sXhs1ChtLw%3D
28. MV Relling ML Hancock JM Boyett CH Pui WE Evans 1999 Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia Blood 93 2817 2823 10216075 1:CAS:528:DyaK1MXivVyltrk%3D (Pubitemid 29200771)
29. C Tani M Mosca R Colucci G Gori A d'Ascanio N Ghisu M Fornai A Di Paolo C Blandizzi M Del Tacca, et al. 2009 Genetic polymorphisms of thiopurine S-methyltransferase in a cohort of patients with systemic autoimmune diseases Clin Exp Rheumatol 27 321 324 19473575 1:STN:280:DC%2BD1MznsVeqsA%3D%3D
30. JP Gisbert P Nino L Rodrigo C Cara LG Guijarro 2006 Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients Am J Gastroenterol 101 2769 2776 17026564 10.1111/j.1572-0241.2006.00843.x 1:CAS:528:DC%2BD2sXht1aqtLo%3D (Pubitemid 44902649)
31. DK Song J Zhao LR Zhang 2006 TPMT genotype and its clinical implication in renal transplant recipients with azathiopurine treatment J Clin Pharm Ther 31 627 635 17176368 10.1111/j.1365-2710.2006.00775.x 1:CAS:528: DC%2BD2sXht1Sisr0%3D (Pubitemid 44813775)
32. JK Rees RG Gray 1990 Remission induction and post remission therapy in acute myelogenous leukemia Haematol Blood Transfus 33 243 248 1691131 1:STN:280:DyaK3c3hsFCitw%3D%3D