Vitamin D metabolism within bone cells: Effects on bone structure and strength

Molecular and Cellular Endocrinology

Volumn 347, Issue 1-2, 2011, Pages 42-47

  Anderson, Paul H ^a,c,d   Atkins, Gerald J ^b,d   Turner, Andrew G ^a,d   Kogawa, Masakazu ^b   Findlay, David M ^b,d   Morris, Howard A ^a,c,d  

^a Endocrine Bone Research Laboratory   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^d HANSON INSTITUTE   (Australia)

Author keywords

Bone architecture; Bone cell metabolism; Osteoblast; Osteoclast; Vitamin D metabolism

Indexed keywords

CALCITRIOL; CALCIUM; COLECALCIFEROL; PARATHYROID HORMONE; PLACEBO;

AUTOCRINE EFFECT; BONE CELL; BONE DENSITY; BONE MINERALIZATION; BONE STRENGTH; BONE STRUCTURE; CALCIUM HOMEOSTASIS; CELL MATURATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CYP27B1 GENE; DIET SUPPLEMENTATION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; HIP FRACTURE; HORMONE ACTION; HUMAN; MARKER GENE; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PARACRINE SIGNALING; PHOSPHATE METABOLISM; PRIORITY JOURNAL; RANKL GENE; REVIEW; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN D METABOLISM;

ANIMALS; BONE DENSITY; HUMANS; MICE; OSTEOBLASTS; OSTEOCLASTS; RATS; VITAMIN D;

EID: 82455162448     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.05.024     Document Type: Review

References (53)

1. Amling M., Priemel M., Holzmann T., Chapin K., Rueger J.M., Baron R., Demay M.B. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 1999, 140:4982-4987.
2. Anderson P.H., Atkins G.J. The skeleton as an intracrine organ for vitamin D metabolism. Mol. Aspects Med. 2008, 29:397-406.
3. 3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. J. Steroid Biochem. Mol. Biol. 2007, 103:601-605.
4. Anderson P.H., Hendrix I., Sawyer R.K., Zarrinkalam R., Manavis J., Sarvestani G.T., May B.K., Morris H.A. Co-expression of CYP27B1 enzyme with the 1.5kb CYP27B1 promoter-luciferase transgene in the mouse. Mol. Cell. Endocrinol. 2008, 285:1-9.
5. Anderson P.H., Sawyer R.K., Moore A.J., May B.K., O'Loughlin P.D., Morris H.A. Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model. J. Bone Miner. Res. 2008, 23:1789-1797.
6. Anderson P.H., Iida S., Tyson J.H.T., Turner A.G., Morris H.A. Bone CYP27B1 gene expression is increased with high dietary calcium and in mineralising osteoblasts. J. Steroid Biochem. Mol. Biol. 2010, 121:71-75.
7. 3 levels. Bone 2005, 36:654-662.
8. Arnala I., Kyrola K., Kroger H., Alhava E.M. Analysis of 245 consecutive hip fracture patients with special reference to bone metabolism. Ann. Chir. Gynaecol. 1997, 86:343-347.
9. Atkins G.J., Anderson P.H., Findlay D.M., Welldon K.J., Vincent C., Zannettino A.C., O'Loughlin P.D., Morris H.A. Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3. Bone 2007, 40:1517-1528.
10. Avenell, A., Gillespie, W.J., Gillespie, L.D., O'Connell, D., 2009. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst. Rev., CD000227.
11. Bell K.L., Loveridge N., Power J., Rushton N., Reeve J. Intracapsular hip fracture: increased cortical remodeling in the thinned and porous anterior region of the femoral neck. Osteoporos. Int. 1999, 10:248-257.
12. Bischoff-Ferrari H.A., Willett W.C., Wong J.B., Giovannucci E., Dietrich T., Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005, 293:2257-2264.
13. Bonjour J.P., Theintz G., Law F., Slosman D., Rizzoli R. Peak bone mass. Osteoporos. Int. 1994, 4(Suppl. 1):7-13.
14. Chapuy M.C., Arlot M.E., Duboeuf F., Brun J., Crouzet B., Arnaud S., Delmas P.D., Meunier P.J. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N. Engl. J. Med. 1992, 327:1637-1642.
15. Dardenne O., Prud'homme J., Hacking S.A., Glorieux F.H., St-Arnaud R. Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1). Bone 2003, 32:332-340.
16. Dwivedi P.P., Anderson P.H., Omdahl J.L., Grimes H.L., Morris H.A., May B.K. Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells. Endocr. Relat. Cancer 2005, 12:351-365.
17. Ebert R., Jovanovic M., Ulmer M., Schneider D., Meissner-Weigl J., Adamski J., Jakob F. Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter. Mol. Endocrinol. 2004, 18:2440-2450.
18. El-Hajj Fuleihan G., Nabulsi M., Tamim H., Maalouf J., Salamoun M., Khalife H., Choucair M., Arabi A., Vieth R. Effect of vitamin D replacement on musculoskeletal parameters in school children: a randomized controlled trial. J. Clin. Endocrinol. Metab. 2006, 91:405-412.
19. Flanagan J.N., Wang L., Tangpricha V., Reichrath J., Chen T.C., Holick M.F. Regulation of the 25-hydroxyvitamin D-1alpha-hydroxylase gene and its splice variant. Recent Results Cancer Res. 2003, 164:157-167.
20. Gao X.H., Dwivedi P.P., Choe S., Alba F., Morris H.A., Omdahl J.L., May B.K. Basal and parathyroid hormone induced expression of the human 25-hydroxyvitamin D 1alpha-hydroxylase gene promoter in kidney AOK-B50 cells: role of Sp1, Ets and CCAAT box protein binding sites. Int. J. Biochem. Cell Biol. 2002, 34:921-930.
21. Geng, S., Zhou, S., Glowacki, J., 2010. Effects of 25-hydroxyvitamin D3 on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1alpha-hydroxylase. J. Bone Miner. Res. doi:10.1002/jbmr.298.
22. Hendrix I., Anderson P.H., Omdahl J.L., May B.K., Morris H.A. Response of the 5'-flanking region of the human 25-hydroxyvitamin D 1{alpha}-hydroxylase gene to physiological stimuli using a transgenic mouse model. J. Mol. Endocrinol. 2005, 34:237-245.
23. Howard G.A., Turner R.T., Sherrard D.J., Baylink D.J. Human bone cells in culture metabolize 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. J. Biol. Chem. 1981, 256:7738-7740.
24. Ichikawa F., Sato K., Nanjo M., Nishii Y., Shinki T., Takahashi N., Suda T. Mouse primary osteoblasts express vitamin D3 25-hydroxylase mRNA and convert 1 alpha-hydroxyvitamin D3 into 1 alpha, 25-dihydroxyvitamin D3. Bone 1995, 16:129-135.
25. Kim M.S., Kondo T., Takada I., Youn M.Y., Yamamoto Y., Takahashi S., Matsumoto T., Fujiyama S., Shirode Y., Yamaoka I., Kitagawa H., Takeyama K., Shibuya H., Ohtake F., Kato S. DNA demethylation in hormone-induced transcriptional derepression. Nature 2009, 461:1007-1012.
26. Kogawa M., Anderson P.H., Findlay D.M., Morris H.A., Atkins G.J. The metabolism of 25(OH)-vitamin D3 by osteoclasts and their precursors regulates the differentiation of osteoclasts. J. Steroid Biochem. Mol. Biol. 2010, 121:277-280.
27. Kogawa M., Findlay D.M., Anderson P.H., Ormsby R., Vincent C., Morris H.A., Atkins G.J. Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption. Endocrinology 2010, 151:4613-4625.
28. Kuchuk N.O., van Schoor N.M., Pluijm S.M., Chines A., Lips P. Vitamin D status, parathyroid function, bone turnover, and BMD in postmenopausal women with osteoporosis: global perspective. J. Bone Miner. Res. 2009, 24:693-701.
29. Lidor C., Sagiv P., Amdur B., Gepstein R., Otremski I., Hallel T., Edelstein S. Decrease in bone levels of 1,25-dihydroxyvitamin D in women with subcapital fracture of the femur. Calcif. Tissue Int. 1993, 52:146-148.
30. Morris H.A., Lee A.M., Sawyer R.K., Iida S., O'Loughlin P.D., Anderson P.H. Increased bone cell vitamin D activity: the basis for synergy between dietary calcium and vitamin D for bone health?. J. Bone Miner. Res. 2010, 25:S131.
31. Morris H.A., Morrison G.W., Burr M., Thomas D.W., Nordin B.E. Vitamin D and femoral neck fractures in elderly South Australian women. Med. J. Aust. 1984, 140:519-521.
32. Murayama A., Kim M.-s., Yanagisawa J., Takeyama K.-i., Kato S. Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching. EMBO J. 2004, 23:1598-1608.
33. Need A.G. Bone resorption markers in vitamin D insufficiency. Clin. Chim. Acta 2006, 368:48-52.
34. Need A.G., Horowitz M., Morris H.A., Moore R., Nordin C. Seasonal change in osteoid thickness and mineralization lag time in ambulant patients. J. Bone Miner. Res. 2007, 22:757-761.
35. Need A.G., O'Loughlin P.D., Morris H.A., Coates P.S., Horowitz M., Nordin B.E. Vitamin D metabolites and calcium absorption in severe vitamin D deficiency. J. Bone Miner. Res. 2008, 23:1859-1863.
36. Owen T.A., Aronow M.S., Barone L.M., Bettencourt B., Stein G.S., Lian J.B. Pleiotropic effects of vitamin D on osteoblast gene expression are related to the proliferative and differentiated state of the bone cell phenotype: dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in normal rat osteoblast cultures. Endocrinology 1991, 128:1496-1504.
37. Panda D.K., Al Kawas S., Seldin M.F., Hendy G.N., Goltzman D. 25-hydroxyvitamin D 1alpha-hydroxylase: structure of the mouse gene, chromosomal assignment, and developmental expression. J. Bone Miner. Res. 2001, 16:46-56.
38. Panda D.K., Miao D., Bolivar I., Li J., Huo R., Hendy G.N., Goltzman D. Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. J. Biol. Chem. 2004, 279:16754-16766.
39. Priemel M., von Domarus C., Klatte T.O., Kessler S., Schlie J., Meier S., Proksch N., Pastor F., Netter C., Streichert T., Puschel K., Amling M. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J. Bone Miner. Res. 2010, 25:305-312.
40. Reichel H., Koeffler H.P., Barbers R., Norman A.W. Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis. J. Clin. Endocrinol. Metab. 1987, 65:1201-1209.
41. Richard C., Huo R., Samadfam R., Bolivar I., Miao D., Brown E.M., Hendy G.N., Goltzman D. The calcium-sensing receptor and 25-hydroxyvitamin D-1alpha-hydroxylase interact to modulate skeletal growth and bone turnover. J. Bone Miner. Res. 2010, 25:1627-1636.
42. Rizzoli R., Bianchi M.L., Garabedian M., McKay H.A., Moreno L.A. Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly. Bone 2010, 46:294-305.
43. Rowling M.J., Gliniak C., Welsh J., Fleet J.C. High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice. J. Nutr. 2007, 137:2608-2615.
44. Sahota O., Masud T., San P., Hosking D.J. Vitamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis. Clin. Endocrinol. (Oxf.) 1999, 51:217-221.
45. Sooy K., Sabbagh Y., Demay M.B. Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitro. J. Cell. Biochem. 2005, 94:81-87.
46. Specker B.L., Ho M.L., Oestreich A., Yin T.A., Shui Q.M., Chen X.C., Tsang R.C. Prospective study of vitamin D supplementation and rickets in China. J. Pediatr. 1992, 120:733-739.
47. St-Arnaud, R., Naja, R.P., accepted for publication. Vitamin D metabolism, cartilage and bone fracture repair. Mol. Cell. Endocrinol., doi:10.1016/j.mce.2011.05.018.
48. Turner A.G., Dwivedi P.P., Anderson P.H., May B.K., Morris H.A. Regulation of the 5'-flanking region of the human CYP27B1 gene in osteoblast cells. Mol. Cell. Endocrinol. 2009, 311:55-61.
49. Turner A.G., Dwivedi P.P., May B.K., Morris H.A. Regulation of the CYP27B1 5'-flanking region by transforming growth factor-beta in ROS 17/2.8 osteoblast-like cells. J. Steroid Biochem. Mol. Biol. 2007, 103:322-325.
50. Turner R.T., Avioli R.C., Bell N.H. Extrarenal metabolism of 25-hydroxycholecalciferol in the rat: regulation by 1,25-dihydroxycholecalciferol. Calcif. Tissue Int. 1984, 36:274-278.
51. van Driel M., Koedam M., Buurman C.J., Hewison M., Chiba H., Uitterlinden A.G., Pols H.A., van Leeuwen J.P. Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells. FASEB J. 2006, 20:2417-2419.
52. van Driel M., Pols H.A., van Leeuwen J.P. Osteoblast differentiation and control by vitamin D and vitamin D metabolites. Curr. Pharm. Des. 2004, 10:2535-2555.
53. von Hurst P.R., Stonehouse W., Kruger M.C., Coad J. Vitamin D supplementation suppresses age-induced bone turnover in older women who are vitamin D deficient. J. Steroid Biochem. Mol. Biol. 2010, 121:293-296.