RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 103, Issue 3-5, 2007, Pages 601-605

  Anderson, P H ^a   Atkins, G J ^a,b   Findlay, D M ^a,b   Oloughlin, P D ^a   Welldon, K ^a,b   Vincent, C ^a,b   Morris, H A ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

25 Hydroxyvitamin D 1 hydroxylase; 25 Hydroxyvitamin D 24 hydroxylase; Osteoblast; Osteocalcin; RNAi

Indexed keywords

25 HYDROXYVITAMIN D 1ALPHA HYDROXYLASE; CALCITRIOL; CYTOCHROME P450 CYP27B1; MESSENGER RNA; OSTEOCALCIN; OXYGENASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BONE CELL; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; GENE REPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA; OSTEOSARCOMA CELL; RNA INTERFERENCE; VITAMIN D METABOLISM;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; CALCITRIOL; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HUMANS; OSTEOCALCIN; OSTEOSARCOMA; RNA INTERFERENCE; RNA, MESSENGER; STEROID HYDROXYLASES;

EID: 33947160596     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2006.12.084     Document Type: Article

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