Response of the 5′-flanking region of the human 25-hydroxyvitamin D 1α-hydroxylase gene to physiological stimuli using a transgenic mouse model

Journal of Molecular Endocrinology

Volumn 34, Issue 1, 2005, Pages 237-245

  Hendrix, I ^a,b   Anderson, P H ^a,b   Omdahl, J L ^c   May, B K ^b   Morris, Howard A ^a,b  

^a HANSON INSTITUTE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIDIOL 1 MONOOXYGENASE; CALCIUM; DNA; LUCIFERASE; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM INTAKE; CONTROLLED STUDY; DIET; DNA FLANKING REGION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN RNA BINDING; RECEPTOR UPREGULATION; REPORTER GENE; TRANSCRIPTION INITIATION; TRANSGENE; TRANSGENIC MOUSE; VITAMIN D DEFICIENCY; AGE; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; METABOLISM; PHYSIOLOGY; PROMOTER REGION;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; 5' FLANKING REGION; AGE FACTORS; ANIMALS; CALCIUM; GENE EXPRESSION REGULATION; GENES, REPORTER; IMMUNOHISTOCHEMISTRY; KIDNEY; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); VITAMIN D DEFICIENCY;

EID: 14544298446     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.01654     Document Type: Article

References (36)

1. Anderson PH, O'Loughlin PD, May BK & Morris HA 2003 Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase-polymerase chain reaction. Journal of Molecular Endocrinology 31 123-132.
2. Armbrecht HJ, Hodam TL & Boltz MA 2003 Hormonal regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and 24-hydroxylase gene transcription in opossum kidney cells. Archives of Biochemistry and Biophysics 409 298-304.
3. Bland R, Walker EA, Hughes SV, Stewart PM & Hewison M 1999 Constitutive expression of 25-hydroxyvitamin D3-1 alpha-hydroxylase in a transformed human proximal tubule cell line: evidence for direct regulation of vitamin D metabolism by calcium. Endocrinology 140 2027-2034.
4. Booth BE, Tsai HC & Morris RC Jr 1985 Vitamin D status regulates 25-hydroxyvitamin D3-1 alpha-hydroxylase and its responsiveness to parathyroid hormone in the chick. Journal of Clinical Investigation 75 155-161.
5. Brenza HL & DeLuca HF 2000 Regulation of 25-hydroxyvitamin D3 1 alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3. Archives of Biochemistry and Biophysics 381 143-152.
6. Brenza HL, Kimmel-Jehan C, Jehan F, Shinki T, Wakino S, Anazawa H, Suda T & DeLuca HF 1998 Parathyroid hormone activation of the 25-hydroxyvitamin D3-1 alpha-hydroxylase gene promoter. PNAS 95 1387-1391.
7. Dardenne O, Prud'homme J, Hacking SA, Glorieux FH & St-Arnaud R 2003 Connection of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorous, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1 alpha-hydroxylase (CYP27B1). Bone 32 332-340.
8. Dusso A, Brown A & Slatopolsky E 1994 Extrarenal production of calcitriol. Seminars in Nephrology 14 144-155.
9. Favus MJ & Langman CB 1986 Evidence for calcium-dependent control of 1,25-dihydroxyvitamin D3 production by rat kidney proximal tubules. Journal of Biological Chemistry 261 11224-11229.
10. Feldman D 1999 Vitamin D, parathyroid hormone, and calcium: a complex regulatory network. American Journal of Medicine 107 637-639.
11. Fox J, Kollenkirchen U & Walters MR 1991 Deficiency of vitamin D metabolites directly stimulates renal 25-hydroxyvitamin D3-1-hydroxylase activity in rats. Metabolism 40 438-441.
12. Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL & Portale AA 1997a Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Molecular Endocrinology 11 1961-1970.
13. Fu GK, Portale AA & Miller WL 1997b Complete structure of the human gene for the vitamin D 1 alpha-hydroxylase, P450c1 alpha. DNA and Cell Biology 16 1499-1507.
14. Gao XH, Dwivedi PP, Choe S, Alba F, Morris HA, Omdahl JL & May BK 2002 Basal and parathyroid hormone induced expression of the human 25-hydroxyvitamin D 1 alpha-hydroxylase gene promoter in kidney AOK-B50 cells: role of Sp 1, Ets and CCAAT box protein binding sites. Internation Journal or Biochemistry and Cell Biology 34 921-930.
15. Hendrix I, Anderson PH, May BK & Morris HA 2004 Regulation of gene expression by the CYP27B1 promoter; study of a transgenic mouse model. Journal of Steroid and Molecular Biology 89-90 139-142.
16. Hewison M, Zehnder D, Bland R & Stewart PM 2000 1 alpha-Hydroxylase and the action of vitamin D. Journal of Molecular Endocrinology 25 141-148.
17. Ishida M, Bulos B, Takamoto S & Sacktor B 1987 Hydroxylation of 25-hydroxyvitamin D3 by renal mitochondria from rats of different ages. Endocrinology 121 443-448.
18. Ishida M, Shima M & Seino Y 1988 1,25(OH)2D and 24,25(OH)2D production in the developing kidney. Pediatric Nephrology 2 166-170.
19. Jones G, Strugnell SA & DeLuca HF 1998 Current understanding of the molecular actions of vitamin D. Physiological Reviews 78 1193-1231.
20. 2+ modulates responsiveness of renal 25(OH)D3-1 alpha-hydroxylase to PTH in rats. American Journal of Physiology 253 E503-507.
21. Murayama A, Takeyama K, Kitanaka S, Kodera Y, Kawaguchi Y, Hosoya T & Kato S 1999 Positive and negative regulations of the renal 25-hydroxyvitamin D3 1 alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1 alpha,25(OH)2D3 in intact animals. Endocrinology 140 2224-2231.
22. Murayama A, Kim M-S, Yanagisawa J, Takeyama K-I & Kato S 2004 Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching. EMBO J 23 1598-1608.
23. O'Loughlin PD & Morris HA 1998 Oestrogen deficiency impairs intestinal calcium absorption in the rat. Journal of Physiology 511 313-322.
24. Omdahl JL, Morris HA & May BK 2002 Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation. Annual Review of Nutrition 22 139-166.
25. Omdahl JL, Bobrovnikova EV, Annalora A, Chen P & Serda R 2003 Expression, structure-function, and molecular modeling of vitamin D P450s. Journal of Cellular Biochemistry 88 356-362.
26. Panda DK, Al Kawas S, Seldin MF, Hendy GN & Goltzman D 2001 25-hydroxyvitamin D 1 alpha-hydroxylase: structure of the mouse gene, chromosomal assignment, and developmental expression. Journal of Bone and Mineral Research 16 46-56.
27. Reeves PG, Nielsen FH & Fahey GC Jr 1993 AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition 123 1939-1951.
28. Reichel H, Koeffler H & Norman A 1989 The role of vitamin D endocrine system in health and disease. New England Journal of Medicine 320 980-991.
29. Shinki T, Shimada H, Wakino S, Anazawa H, Hayashi M, Saruta T, DeLuca HF & Suda T 1997 Cloning and expression of rat 25-hydroxyvitamin D3-1 alpha-hydroxylase cDNA. PNAS 94 12920-12925.
30. St-Arnaud R, Messerlian S, Moir JM, Omdahl JL & Glorieux FH 1997 The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. Journal of Bone and Mineral Research 12 1552-1559.
31. Suda T, Horiuchi N, Sasaki S, Ogata E & Ezawa I 1973 Direct control by calcium of 25-hydroxycholecalciferol-1-hydroxylase activity in chick kidney mitochondria. Biochemical and Biophysical Research Communications 54 512-518.
32. Warner M & Tenenhouse A 1985 Regulation of renal vitamin D hydroxylase activity in vitamin D deficient rats. Canadian Journal of Physiology and Pharmacology 63 978-982.
33. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, Kawakami T, Arioka K, Sato H, Uchimyama Y et al. 1997 Mice lacking vitamin D receptor exhibit impaired bone formation uterine hypoplasia and growth retardation after weaning. Nature Genetics 16 391-396.
34. Zehnder D, Bland R, Walker EA, Bradwell AR, Howie AJ, Hewison M & Stewart PM 1999 Expression of 25-hydroxyvitamin D3-1 alpha-hydroxylase in the human kidney. Journal of the American Society of Nephrology 10 2465-2473.
35. Zhang MY, Wang X, Wang JT, Compagnone NA, Mellon SH, Olson JL, Tenenhouse HS, Miller WL & Portale AA 2002 Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1 alpha-hydroxylase gene expression in the proximal renal tubule. Endocrinology 143 587-595.
36. Zierold C, Mings JA & DeLuca HF 2001 Parathyroid hormone regulates 25-hydroxyvitamin D(3)-24-hydroxylase mRNA by altering its stability. PNAS 98 13572-13576.