Bone CYP27B1 gene expression is increased with high dietary calcium and in mineralising osteoblasts

Journal of Steroid Biochemistry and Molecular Biology

Volumn 121, Issue 1-2, 2010, Pages 71-75

  Anderson, Paul H ^a   Iida, Shunji ^b   Tyson, Juliette H T ^a   Turner, Andrew G ^a   Morris, Howard A ^a,c  

^a Chemical Pathology   (Australia)

^b HOKKAIDO UNIVERSITY   (Japan)

^c UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

25 Hydroxyvitamin D 1 hydroxylase; Bone; Mineralisation; Osteoblasts

Indexed keywords

ALKALINE PHOSPHATASE; MESSENGER RNA; OSTEOCALCIN; VITAMIN D; VITAMIN D RECEPTOR; CALCIDIOL 1 MONOOXYGENASE; CALCIUM INTAKE;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE; BONE CELL; BONE DEVELOPMENT; BONE MINERALIZATION; CALCIUM BLOOD LEVEL; CALCIUM INTAKE; CELL CULTURE; COMPARATIVE STUDY; CYP27B1 GENE; FEMALE; GENE; GENE EXPRESSION; IN VIVO STUDY; KIDNEY; NONHUMAN; OSTEOBLAST; PROMOTER REGION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VITAMIN SUPPLEMENTATION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; GENE EXPRESSION REGULATION; METABOLISM; MOUSE; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANIMALS; BONE AND BONES; CALCIUM, DIETARY; FEMALE; GENE EXPRESSION REGULATION; KIDNEY; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; OSTEOBLASTS; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN D;

ANIMALIA; MUS; RATTUS;

EID: 77954759122     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.03.021     Document Type: Article

References (23)

1. Anderson P.H., O'Loughlin P.D., May B.K., Morris H.A. Determinants of circulating 1,25-dihydroxyvitamin D(3) levels: the role of renal synthesis and catabolism of vitamin D. J. Steroid Biochem. Mol. Biol. 2004, 89-90:111-113.
2. Dusso A., Brown A., Slatopolsky E. Extrarenal production of calcitriol. Semin. Nephrol. 1994, 14:144-155.
3. Zehnder D., Bland R., Williams M.C., McNinch R.W., Howie A.J., Stewart P.M., Hewison M. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J. Clin. Endocrinol. Metab. 2001, 86:888-894.
4. Atkins G.J., Anderson P.H., Findlay D.M., Welldon K.J., Vincent C., Zannettino A.C., O'Loughlin P.D., Morris H.A. Metabolism of vitamin D(3) in human osteoblasts: evidence for autocrine and paracrine activities of 1alpha,25-dihydroxyvitamin D(3). Bone 2007, 40:1517-1528.
5. van Driel M., Koedam M., Buurman C.J., Hewison M., Chiba H., Uitterlinden A.G., Pols H.A., van Leeuwen J.P. Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells. FASEB J. 2006, 20:2417-2419.
6. Anderson P.H., Atkins G.J., Findlay D.M., Oloughlin P.D., Welldon K., Vincent C., Morris H.A. RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. J. Steroid Biochem. Mol. Biol. 2007, 103:601-605.
7. Anderson P.H., O'Loughlin P.D., May B.K., Morris H.A. Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)2D3 levels. Bone 2005, 36:654-662.
8. Turner A.G., Dwivedi P.P., Anderson P.H., May B.K., Morris H.A. Regulation of the 5'-flanking region of the human CYP27B1 gene in osteoblast cells. Mol. Cell. Endocrinol. 2009, 311:55-61.
9. Reeves P.G., Nielsen F.H., Fahey G.C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 1993, 123:1939-1951.
10. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 1987, 162:156-159.
11. Davey R.A., Hahn C.N., May B.K., Morris H.A. Osteoblast gene expression in rat long bones: effects of ovariectomy and dihydrotestosterone on mRNA levels. Calcif. Tissue Int. 2000, 67:75-79.
12. Anderson P.H., O'Loughlin P.D., May B.K., Morris H.A. Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase-polymerase chain reaction. J. Mol. Endocrinol. 2003, 31:123-132.
13. Anderson P.H., Hendrix I., Sawyer R.K., Zarrinkalam R., Manavis J., Sarvestani G.T., May B.K., Morris H.A. Co-expression of CYP27B1 enzyme with the 1.5kb CYP27B1 promoter-luciferase transgene in the mouse. Mol. Cell. Endocrinol. 2008, 285:1-9.
14. Hendrix I., Anderson P., May B., Morris H. Regulation of gene expression by the CYP27B1 promoter-study of a transgenic mouse model. J. Steroid Biochem. Mol. Biol. 2004, 89-90:139-142.
15. Hendrix I., Anderson P.H., Omdahl J.L., May B.K., Morris H.A. Response of the 5'-flanking region of the human 25-hydroxyvitamin D 1{alpha}-hydroxylase gene to physiological stimuli using a transgenic mouse model. J. Mol. Endocrinol. 2005, 34:237-245.
16. Naja R.P., Dardenne O., Arabian A., St Arnaud R. Chondrocyte-specific modulation of Cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development. Endocrinology 2009, 150:4024-4032.
17. 3 by osteoclasts and their precursors regulates the differentiation of osteoclasts. J. Steroid Biochem. Mol. Biol. 2010, 121:277-280.
18. Turner A.G., Dwivedi P.P., May B.K., Morris H.A. Regulation of the CYP27B1 5'-flanking region by transforming growth factor-beta in ROS 17/2.8 osteoblast-like cells. J. Steroid Biochem. Mol. Biol. 2007, 103:322-325.
19. Reichel H., Koeffler H.P., Barbers R., Norman A.W. Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis. J. Clin. Endocrinol. Metab. 1987, 65:1201-1209.
20. Murayama A., Kim M.-s., Yanagisawa J., Takeyama K.-i., Kato S. Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching. EMBO J. 2004, 23:1598-1608.
21. Anderson P.H., Iida S., Moore A.J., Cochran M., O'Loughlin P.D., May B.K., Morris H.A. Bone Cyp27b1 mRNA is regulated by dietary calcium and not vitamin D status. J. Bone Miner. Res. 2001, 16:S313-S1313.
22. Anderson P.H., Iida S., Moore A.J., May B.K., Cochran M., Morris H.A. Bone cell regulation of vitamin D metabolism. Bone 2001, 28:S245-S246.
23. Gardiner E.M., Baldock P.A., Thomas G.P., Sims N.A., Henderson N.K., Hollis B., White C.P., Sunn K.L., Morrison N.A., Walsh W.R., Eisman J.A. Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage. FASEB J. 2000, 14:1908-1916.