Bacteria-mediated disease therapy

Applied Microbiology and Biotechnology

Volumn 92, Issue 6, 2011, Pages 1107-1113

  Yu, Hao ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anti inflammatory; Antitumor; Antivirus; Bacteriolytic; Gene therapy; Oncolytic; Probiotics

Indexed keywords

ANTI VIRUS; ANTI-INFLAMMATORIES; ANTI-TUMORS; BACTERIOLYTIC; ONCOLYTIC; PROBIOTICS;

BACTERIOLOGY; DISEASE CONTROL; DISEASES; GENE THERAPY; MOLECULAR BIOLOGY; TUMORS; VIRUSES;

BACTERIA;

ANTINEOPLASTIC AGENT; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 8; LYMPHOTOXIN; PROBIOTIC AGENT; TUMOR NECROSIS FACTOR;

BACTERIUM; BIOTECHNOLOGY; IMMUNOASSAY; LABORATORY METHOD; MITOCHONDRIAL DNA; MOLECULAR ANALYSIS; PROBIOTICS; TUMOR;

ANAEROBIC BACTERIUM; ANTIBIOTIC RESISTANCE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ANTIVIRAL THERAPY; BACTEROIDES FRAGILIS; BIFIDOBACTERIUM BIFIDUM; BIFIDOBACTERIUM LONGUM; BIFIDOBACTERIUM LONGUM INFANTIS; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CELL ACTIVATION; CLINICAL EFFECTIVENESS; CLOSTRIDIUM BUTYRICUM; CLOSTRIDIUM TETANI; COLITIS; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; DNA IMMUNIZATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; ENTERITIS; ESCHERICHIA COLI; GENE DELETION; GENE FUNCTION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNITY; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY DISEASE; LACTOBACILLUS PLANTARUM; LACTOBACILLUS REUTERI; NONHUMAN; PROTEIN EXPRESSION; REMISSION; REVIEW; SACCHAROMYCES BOULARDII; SALMONELLA; SALMONELLA ENTERICA; SEPTIC SHOCK; STOMACH CANCER; TRANSITIONAL CELL CARCINOMA; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; BACTERIA; BACTERIAL PHYSIOLOGICAL PHENOMENA; BIOLOGICAL THERAPY; DRUG THERAPY; GENETIC THERAPY; HUMANS; PROBIOTICS;

BACTERIA (MICROORGANISMS); SALMONELLA;

EID: 82455162372     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3648-x     Document Type: Review

References (77)

1. C Agorio F Schreiber M Sheppard P Mastroeni M Fernandez MA Martinez JA Chabalgoity 2007 Live attenuated Salmonella as a vector for oral cytokine gene therapy in melanoma J Gene Med 9 416 423 10.1002/jgm.1023 1:CAS:528: DC%2BD2sXntlOhtro%3D (Pubitemid 46796587)
2. N Agrawal C Bettegowda I Cheong JF Geschwind CG Drake EL Hipkiss M Tatsumi LH Dang LA Diaz Jr M Pomper M Abusedera RL Wahl KW Kinzler S Zhou DL Huso B Vogelstein 2004 Bacteriolytic therapy can generate a potent immune response against experimental tumors Proc Natl Acad Sci U S A 101 15172 15177 10.1073/pnas.0406242101 1:CAS:528:DC%2BD2cXpsVSgtr8%3D (Pubitemid 39391737)
3. N Arrach M Zhao S Porwollik RM Hoffman M McClelland 2008 Salmonella promoters preferentially activated inside tumors Cancer Res 68 4827 4832 10.1158/0008-5472.CAN-08-0552 1:CAS:528:DC%2BD1cXnt1ejsLk%3D
4. Y Bai H Gong H Li GP Vu S Lu F Liu 2011 Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice Proc Natl Acad Sci U S A 108 3222 3227 10.1073/pnas.1014975108 1:CAS:528:DC%2BC3MXislyjurs%3D
5. D Bermudes B Low J Pawelek 2000 Tumor-targeted Salmonella. Highly selective delivery vectors Adv Exp Med Biol 465 57 63 10.1007/0-306-46817-4-6 1:STN:280:DC%2BD3c3ntV2isA%3D%3D (Pubitemid 32193323)
6. G Capurso M Marignani M Piciucchi E Merola G Delle Fave 2008 Probiotics and severe acute pancreatitis J Clin Gastroenterol 42 Suppl 3 Pt 1 S148 S151 10.1097/MCG.0b013e318169e935
7. D Castanotto JJ Rossi 2009 The promises and pitfalls of RNA-interference-based therapeutics Nature 457 426 433 10.1038/nature07758 1:CAS:528:DC%2BD1MXotlOgsA%3D%3D
8. R Catlett-Falcone WS Dalton R Jove 1999 STAT proteins as novel targets for cancer therapy Curr Opin Oncol 11 490 496 10.1097/00001622-199911000-00010 1:CAS:528:DyaK1MXns12qsLg%3D (Pubitemid 29515894)
9. I Cheong X Huang C Bettegowda LA Diaz Jr KW Kinzler S Zhou B Vogelstein 2006 A bacterial protein enhances the release and efficacy of liposomal cancer drugs Science 314 1308 1311 10.1126/science.1130651 1:CAS:528:DC%2BD28Xht1agt7nM (Pubitemid 44846406)
10. LH Dang C Bettegowda DL Huso KW Kinzler B Vogelstein 2001 Combination bacteriolytic therapy for the treatment of experimental tumors Proc Natl Acad Sci U S A 98 15155 15160 10.1073/pnas.251543698 1:CAS:528:DC%2BD38XpsVWq (Pubitemid 34013985)
11. H De Winter H Cheroutre M Kronenberg 1999 Mucosal immunity and inflammation. II. The yin and yang of T cells in intestinal inflammation: pathogenic and protective roles in a mouse colitis model Am J Physiol 276 G1317 G1321
12. C Di Giacinto M Marinaro M Sanchez W Strober M Boirivant 2005 Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells J Immunol 174 3237 3246 (Pubitemid 40354026)
13. CO Elson Y Cong CT Weaver TR Schoeb TK McClanahan RB Fick RA Kastelein 2007 Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice Gastroenterology 132 2359 2370 10.1053/j.gastro.2007.03.104 1:CAS:528:DC%2BD2sXnvFOhtb8%3D (Pubitemid 46890867)
14. O Epaulard B Toussaint L Quenee M Derouazi N Bosco C Villiers R Le Berre B Guery D Filopon L Crombez PN Marche B Polack 2006 Anti-tumorimmunotherapy via antigen delivery from a live attenuated genetically engineered Pseudomonas aeruginosa type III secretion system-based vector Mol Ther 14 656 661 10.1016/j.ymthe.2006.06.011 1:CAS:528:DC%2BD28XhtVGju7vK (Pubitemid 44480761)
15. BB Finlay G McFadden 2006 Anti-immunology: evasion of the host immune system by bacterial and viral pathogens Cell 124 767 782 10.1016/j.cell.2006.01. 034 1:CAS:528:DC%2BD28Xit1Kltb4%3D (Pubitemid 43261451)
16. DN Frank AL St Amand RA Feldman EC Boedeker N Harpaz NR Pace 2007 Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases Proc Natl Acad Sci U S A 104 13780 13785 10.1073/pnas.0706625104 1:CAS:528:DC%2BD2sXpvVGjsbg%3D (Pubitemid 350003397)
17. R Gardlik M Behuliak R Palffy P Celec CJ Li 2011 Gene therapy for cancer: bacteria-mediated anti-angiogenesis therapy Gene Ther 18 425 431 10.1038/gt.2010.176 1:CAS:528:DC%2BC3MXkvFaruw%3D%3D
18. M Guslandi G Mezzi M Sorghi PA Testoni 2000 Saccharomyces boulardii in maintenance treatment of Crohn's disease Dig Dis Sci 45 1462 1644 10.1023/A:1005588911207 1:STN:280:DC%2BD3cvislamsA%3D%3D (Pubitemid 30636526)
19. M Heisig A Frentzen B Bergmann K Galmbacher I Gentschev C Hotz C Schoen J Stritzker J Fensterle UR Rapp W Goebel 2011 Specific antibody-receptor interactions trigger InlAB-independent uptake of Listeria monocytogenes into tumor cell lines BMC Microbiol 11 163 10.1186/1471-2180-11-163 1:CAS:528:DC%2BC3MXhtVeht7fI
20. J Hess L Grode J Hellwig P Conradt I Gentschev W Goebel C Ladel SH Kaufmann 2009 Protection against murine tuberculosis by an attenuated recombinant Salmonella typhimurium vaccine strain that secretes the 30-kDa antigen of Mycobacterium bovis BCG FEMS Immunol Med Microbiol 27 283 289 10.1111/j.1574-695X.2000.tb01441.x
21. LV Hooper JI Gordon 2001 Commensal host-bacterial relationships in the gut Science 292 1115 1118 10.1126/science.1058709 1:CAS:528:DC%2BD3MXjs1Chtbk%3D (Pubitemid 32440925)
22. SA Khan P Everest S Servos N Foxwell U Zähringer H Brade ET Rietschel G Dougan IG Charles DJ Maskell 1998 A lethal role for lipid A in Salmonella infections Mol Microbiol 29 571 579 10.1046/j.1365-2958.1998.00952.x 1:CAS:528:DyaK1cXltVOnsLo%3D (Pubitemid 28330789)
23. NT Kimura S Taniguchi K Aoki T Baba 1980 Selective localization and growth of Bifidobacterium bifidum in mouse tumours following intravenous administration Cancer Res 40 2061 2068 1:STN:280:DyaL3c7nslSjtA%3D%3D (Pubitemid 10116138)
24. W Kruis E Schut P Fric B Fixa G Judmaier M Stolte 1997 Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis Aliment Pharmacol Ther 11 853 858 10.1046/j.1365-2036.1997.00225.x 1:CAS:528:DyaK2sXntFChtb8%3D
25. CH Lee CL Wu AL Shiau 2004 Endostatin gene therapy delivered by Salmonella choleraesuis in murine tumor models J Gene Med 6 1382 1393 10.1002/jgm.626 1:CAS:528:DC%2BD2MXhsVeiu7k%3D (Pubitemid 40287709)
26. JS Lee NS Paek OS Kwon KB Hahm 2010 Anti-inflammatory actions of probiotics through activating suppressor of cytokine signaling (SOCS) expression and signaling in Helicobacter pylori infection: a novel mechanism J Gastroenterol Hepatol 25 194 202 10.1111/j.1440-1746.2009.06127.x 1:CAS:528:DC%2BC3cXhs1Kltbk%3D
27. Y Li K Guo H Chen Y Xie C Song T Xun D Ren 2001 Oral cytokine gene therapy against murine tumor using attenuated Salmonella typhimurium Int J Cancer 94 438 443 10.1002/ijc.1489 1:CAS:528:DC%2BD3MXnsVersb8%3D (Pubitemid 32906078)
28. C Loguercio A Federico C Tuccillo F Terracciano MV D'Auria C De Simone BC Del Vecchio 2005 Beneficial effect of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases J Clin Gastroenterol 39 540 543 10.1097/01.mcg.0000165671.25272.0f (Pubitemid 40863651)
29. KB Low M Ittensohn T Le J Platt S Sodi M Amoss O Ash E Carmichael A Chakraborty J Fischer SL Lin X Luo SI Miller L Zheng I King JM Pawelek D Bermudes 1999 Lipid A mutant Salmonella with suppressed virulence and TNF alpha induction retain tumour-targeting in vivo Nat Biotechnol 17 37 41 1:CAS:528:DyaK1MXks1OisQ%3D%3D (Pubitemid 29037207)
30. KB Low M Ittensohn X Luo LM Zheng I King JM Pawelek D Bermudes 2004 Construction of VNP20009: a novel, genetically stable antibiotic-sensitive strain of tumor-targeting Salmonella for parenteral administration in humans Methods Mol Med 90 47 60 1:CAS:528:DC%2BD2cXitlCg
31. Y Luo MJ Knudson 2010 Mycobacterium bovis bacillus Calmette- Guérin-induced macrophage cytotoxicity against bladder cancer cells Clin Dev Immunol 2010 357591 10.1155/2010/357591
32. K Madsen A Cornish P Soper C McKaigney H Jijon C Yachimec J Doyle L Jewell C De Simone 2001 Probiotic bacteria enhance murine and human intestinal epithelial barrier function Gastroenterology 121 580 591 10.1053/gast.2001.27224 1:STN:280:DC%2BD3MvnvFSmsw%3D%3D (Pubitemid 32822573)
33. R Malmgren C Flanigan 1955 Localisation of the vegetative form of Clostridium tetani in mouse tumours following intravenous spore administration Cancer Res 15 473 478 1:STN:280:DyaG2M7gt12mtQ%3D%3D
34. SK Mazmanian CH Liu AO Tzianabos DL Kasper 2005 An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system Cell 122 107 118 10.1016/j.cell.2005.05.007 1:CAS:528:DC%2BD2MXmsFeiurw%3D (Pubitemid 40977944)
35. E Mills K Baruch X Charpentier S Kobi I Rosenshine 2008 Real-time analysis of effector translocation by the type III secretion system of enteropathogenic Escherichia coli Cell Host Microbe 3 104 113 10.1016/j.chom.2007.11.007 1:CAS:528:DC%2BD1cXis12ls70%3D (Pubitemid 351201782)
36. LB Mora R Buettner J Seigne J Diaz N Ahmad R Garcia T Bowman R Falcone R Fairclough A Cantor C Muro-Cacho S Livingston J Karras J Pow-Sang R Jove 2002 Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells Cancer Res 62 6659 6666 1:CAS:528:DC%2BD38XovFOksLw%3D (Pubitemid 35364135)
37. JR Möse G Möse 1964 Oncolysis by Clostridia I. Activity of Clostridium butyricum (M-55) and other nonpathogenic Clostridia against the Ehrlich carcinoma Cancer Res 24 212 216
38. S Nuyts L Van Mellaert J Theys W Landuyt E Bosmans J Anné P Lambin 2001 Radio-responsive recA promoter significantly increases TNF alpha production in recombinant clostridia after 2 Gy irradiation Gene Ther 8 1197 1201 10.1038/sj.gt.3301499 1:CAS:528:DC%2BD3MXlvVSlsbc%3D (Pubitemid 32776394)
39. C O'Mahony P Scully D O'Mahony S Murphy F O'Brien A Lyons G Sherlock J MacSharry B Kiely F Shanahan L O'Mahony 2008 Commensal-induced regulatory T cells mediate protection against pathogen stimulated NF-κB activation PLoS Pathog 4 e1000112 10.1371/journal.ppat.1000112
40. R Pálffy R Gardlík J Hodosy M Behuliak P Resko J Radvánský P Celec 2006 Bacteria in gene therapy: bactofection versus alternative gene therapy Gene Ther 13 101 105 10.1038/sj.gt.3302635 (Pubitemid 43039902)
41. S Park WS Kim UJ Choi SU Han YS Kim YB Kim MH Chung KT Nam DY Kim SW Cho KB Hahm 2004 Amelioration of oxidative stress with ensuing inflammation contributes to chemoprevention of H. pylori-associated gastric carcinogenesis Antioxid Redox Signal 6 549 560 10.1089/152308604773934305 1:CAS:528: DC%2BD2cXjslahu7s%3D (Pubitemid 38625375)
42. KT Park AJ Allen JP Bannantine KS Seo MJ Hamilton GS Abdellrazeq HM Rihan A Grimm WC Davis 2011 Evaluation of two mutants of Mycobacterium avium subsp. paratuberculosis as candidates for a live attenuated vaccine for Johne's disease Vaccine 29 4709 4719 10.1016/j.vaccine.2011.04.090 1:CAS:528: DC%2BC3MXntlGjtbw%3D
43. JM Pawelek K Brooks Low D Bermudes 1997 Tumour-targeted Salmonella as a novel anticancer vector Cancer Res 57 4537 4544 1:CAS:528:DyaK2sXmslKqt7Y%3D (Pubitemid 27441058)
44. R Penner RN Fedorak KL Madsen 2005 Probiotics and nutraceuticals: non-medicinal treatments of gastrointestinal diseases Curr Opin Pharmacol 5 596 603 10.1016/j.coph.2005.06.009 1:CAS:528:DC%2BD2MXhtFKntrjP (Pubitemid 41614458)
45. DK Podolsky 2002 Inflammatory bowel disease N Engl J Med 347 417 429 10.1056/NEJMra020831 1:CAS:528:DC%2BD38XlvFKrt7s%3D (Pubitemid 34851835)
46. C Prantera ML Scribano G Falasco A Andreoli C Luzi 2002 Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG Gut 51 405 409 10.1136/gut.51.3.405 1:STN:280:DC%2BD38vhvVSksA%3D%3D
47. V Quagliarello WM Scheld 1992 Bacterial meningitis: pathogenesis, pathophysiology, and progress N Engl J Med 327 864 872 10.1056/ NEJM199209173271208 1:CAS:528:DyaK3sXnvVSmtQ%3D%3D
48. S Redpath P Ghazal NR Gascoigne 2001 Hijacking and exploitation of IL-10 by intracellular pathogens Trends Microbiol 9 86 92 10.1016/S0966-842X(00)01919- 3 1:CAS:528:DC%2BD3MXlvFChtrY%3D (Pubitemid 32155327)
49. BJ Rembacken AM Snelling PM Hawkey DM Chalmers AT Axon 1999 Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial Lancet 354 635 639 10.1016/S0140-6736(98) 06343-0 1:STN:280:DyaK1MzpsVGnsw%3D%3D (Pubitemid 29391428)
50. JL Round SK Mazmanian 2009 The gut microbiota shapes intestinal immune responses during health and disease Nat Rev Immunol 9 313 323 10.1038/nri2515 1:CAS:528:DC%2BD1MXjvF2gtbk%3D
51. RM Ryan J Green CE Lewis 2005 Use of bacteria in anti-cancer therapies Bioessays 28 84 94 10.1002/bies.20336
52. J Sanchez J Holmgren 2011 Cholera toxin-a foe & a friend Indian J Med Res 133 153 163 1:CAS:528:DC%2BC3MXlvFGlsLY%3D
53. T Sasaki M Fujimori Y Hamaji Y Hama K Ito J Amano S Taniguchi 2006 Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats Cancer Sci 97 649 657 10.1111/j.1349-7006.2006.00221.x 1:CAS:528:DC%2BD28XmsVOntLg%3D (Pubitemid 44056614)
54. LJ Scherer JJ Rossi 2003 Approaches for the sequence-specific knockdown of mRNA Nat Biotechnol 21 1457 1465 10.1038/nbt915 1:CAS:528: DC%2BD3sXpt1Gltbw%3D (Pubitemid 37522705)
55. M Schultz C Veltkamp LA Dieleman WB Grenther PB Wyrick SL Tonkonogy RB Sartor 2002 Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice Inflamm Bowel Dis 8 71 80 10.1097/00054725-200203000-00001 (Pubitemid 34213503)
56. V Shahabi PC Maciag S Rivera A Wallecha 2010 Live, attenuated strains of Listeria and Salmonella as vaccine vectors in cancer treatment Bioeng Bugs 1 235 239
57. SJ Simpson YP de Jong M Comiskey C Terhorst 2000 Pathways of T cell pathology in models of chronic intestinal inflammation Int Rev Immunol 19 1 37 10.3109/08830180009048387 1:CAS:528:DC%2BD3cXisFOitrk%3D (Pubitemid 30146940)
58. H Sokol B Pigneur L Watterlot O Lakhdari LG Bermúdez- Humarán JJ Gratadoux S Blugeon C Bridonneau JP Furet G Corthier C Grangette N Vasquez P Pochart G Trugnan G Thomas HM Blottière J Doré P Marteau P Seksik P Langella 2008 Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients Proc Natl Acad Sci U S A 105 16731 16736 10.1073/pnas.0804812105 1:CAS:528:DC%2BD1cXhtleks7%2FI
59. H Stöber E Maier H Schmidt 2010 Protective effects of Lactobacilli, Bifidobacteria and Staphylococci on the infection of cultured HT29 cells with different enterohemorrhagic Escherichia coli serotypes are strain-specific Int J Food Microbiol 144 133 140 10.1016/j.ijfoodmicro.2010.09.010
60. J Stritzker S Weibel PJ Hill TA Oelschlaeger W Goebel AA Szalay 2007 Tumor-specific colonization, tissue distribution, and gene induction by probiotic Escherichia coli Nissle 1917 in live mice Int J Med Microbiol 297 151 162 10.1016/j.ijmm.2007.01.008 1:CAS:528:DC%2BD2sXot1SqsLY%3D (Pubitemid 46678925)
61. J Stritzker S Pilgrim AA Szalay W Goebel 2008 Prodrug converting enzyme gene delivery by L. monocytogenes BMC Cancer 8 94 10.1186/1471-2407-8-94 (Pubitemid 351587050)
62. L Terradot G Waksman 2011 Architecture of the Helicobacter pylori Cag-type IV secretion system FEBS J 278 1213 1222 10.1111/j.1742-4658.2011. 08037.x 1:CAS:528:DC%2BC3MXltFGhurg%3D
63. MQ Wei KA Ellem P Dunn MJ West CX Bai B Vogelstein 2006 Facultative or obligate anaerobic bacteria have the potential for multimodality therapy of solid tumours Eur J Cancer 43 490 496 10.1016/j.ejca.2006.10.005 (Pubitemid 46177582)
64. LM Wood ZK Pan P Guirnalda P Tsai M Seavey Y Paterson 2011 Targeting tumor vasculature with novel Listeria-based vaccines directed against CD105 Cancer Immunol Immunother 60 931 942 10.1007/s00262-011-1002-x 1:CAS:528:DC%2BC3MXnslOrsrc%3D
65. R Xiang HN Lode TH Chao JM Ruehlmann CS Dolman F Rodriguez JL Whitton WW Overwijk NP Restifo RA Reisfeld 2000 An autologous oral DNA vaccine protects against murine melanoma Proc Natl Acad Sci U S A 97 5492 5497 10.1073/pnas.090097697 1:CAS:528:DC%2BD3cXjsVWms74%3D (Pubitemid 30313746)
66. S Xiang J Fruehauf CJ Li 2006 Short hairpin RNA-expressing bacteria elicit RNA interference in mammals Nat Biotechnol 24 697 702 10.1038/nbt1211 1:CAS:528:DC%2BD28XlsVequ7s%3D (Pubitemid 43882121)
67. R Xiang Y Luo AG Niethammer RA Reisfeld 2008 Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis Immunol Rev 222 117 128 10.1111/j.1600-065X.2008.00613.x 1:CAS:528: DC%2BD1cXlsFejtrg%3D (Pubitemid 351430375)
68. N Yang SH Li YZ Lü LS Chen DM Ren 2011 Attenuated Salmonella typhimurium carrying shRNA-expressing vectors elicit RNA interference in murine bladder tumors Acta Pharmacol Sin 32 368 374 10.1038/aps.2010.224 1:CAS:528:DC%2BC3MXislCjsLk%3D
69. K Yazawa M Fujimori J Amano Y Kano S Taniguchi 2000 Bifidobacterium longum as a delivery system for cancer gene therapy: selective localization and growth in hypoxic tumours Cancer Gene Ther 7 269 274 10.1038/sj.cgt.7700122 1:CAS:528:DC%2BD3cXit1ygsLc%3D (Pubitemid 30194562)
70. WS Yoon YS Chae J Hong YK Park 2011 Antitumor therapeutic effects of a genetically engineered Salmonella typhimurium harboring TNF-α in mice Appl Microbiol Biotechnol 89 1807 1819 10.1007/s00253-010-3006-4 1:CAS:528:DC%2BC3MXitlaktLs%3D
71. H Yu KS Kim 2010 Ferredoxin is involved in secretion of cytotoxic necrotizing factor 1 across the cytoplasmic membrane in Escherichia coli K1 Infect Immun 78 838 844 10.1128/IAI.00674-09 1:CAS:528:DC%2BC3cXhslejtrs%3D
72. H Yu KS Kim 2011 The involvement of SelB in expression of cytotoxic necrotizing factor 1 in Escherichia coli FEBS Lett 585 1934 1940 10.1016/j.febslet.2011.05.012 1:CAS:528:DC%2BC3MXnsVShsb8%3D
73. H Yu W Peng Y Liu T Wu Y Yao M Cui W Jiang G Zhao 2006 Identification and characterization of glnA promoter and its corresponding trans-regulatory protein GlnR in the rifamycin SV producing actinomycete, Amycolatopsis mediterranei U32 Acta Biochim Biophys Sin 38 831 843 10.1111/j.1745-7270.2006. 00238.x 1:CAS:528:DC%2BD2sXht1agu7Y%3D (Pubitemid 44952886)
74. H Yu Y Yao Y Liu R Jiao W Jiang G Zhao 2007 A complex role of Amycolatopsis mediterranei GlnR in nitrogen metabolism and related antibiotics production Arch Microbiol 188 89 96 10.1007/s00203-007-0228-7 1:CAS:528:DC%2BD2sXmtl2jt74%3D (Pubitemid 46919115)
75. ZS Yuksel E Buber T Kocagoz A Alp Z Saribas NL Acan 2011 Mycobacterial strains that stimulate the immune system most efficiently as candidates for the treatment of bladder cancer J Mol Microbiol Biotechnol 20 24 28 10.1159/000324331 1:CAS:528:DC%2BC3MXisl2rtrg%3D
76. L Zhang L Gao L Zhao B Guo K Ji Y Tian J Wang H Yu J Hu DV Kalvakolanu DJ Kopecko X Zhao DQ Xu 2007 Intratumoral delivery and suppression of prostate tumor growth by attenuated Salmonella enterica serovar typhimurium carrying plasmid-based small interfering RNAs Cancer Res 67 5859 5864 10.1158/0008-5472.CAN-07-0098 1:CAS:528:DC%2BD2sXmsFCqtrs%3D (Pubitemid 46985020)
77. M Zhao M Yang XM Li P Jiang E Baranov S Li M Xu S Penman RM Hoffman 2005 Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium Proc Natl Acad Sci U S A 102 755 760 10.1073/pnas. 0408422102 1:CAS:528:DC%2BD2MXis1CqsLs%3D (Pubitemid 40282738)