Lipid a mutant Salmonella with suppressed virulence and TNFα induction retain tumor-targeting in vivo

Nature Biotechnology

Volumn 17, Issue 1, 1999, Pages 37-41

  Low, K Brooks ^a   Ittensohn, Martina ^b   Le, Trung ^b   Platt, James ^a   Sodi, Stefano ^a   Amoss, Max ^c   Ash, Olivia ^c   Carmichael, Ellen ^b   Chakraborty, Ashok ^a   Fischer, Jessica ^b   Lin, Stanley L ^b   Luo, Xiang ^b   Miller, Samuel I ^d   Zheng, Li Mou ^b   King, Ivan ^b   Pawelek, John M ^a   Bermudes, David ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Vion Pharmaceuticals Incorporated   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Attenuation; Cancer; Gene therapy; msbB; Salmonella; Septic shock; TNF ; Tumor specific

Indexed keywords

LIPID A; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM MUTANT; BIOACCUMULATION; CYTOKINE PRODUCTION; GENE DISRUPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA; SWINE;

ACYLTRANSFERASES; ANIMALS; BACTERIAL PROTEINS; CELL SURVIVAL; ESCHERICHIA COLI PROTEINS; HUMANS; LIPID A; LIVER; MACROPHAGES; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED STRAINS; NEOPLASM TRANSPLANTATION; RESPIRATION; SALMONELLA; SALMONELLA INFECTIONS, ANIMAL; SEQUENCE DELETION; SHOCK, SEPTIC; SKIN NEOPLASMS; SWINE; TUMOR NECROSIS FACTOR-ALPHA; VIRULENCE;

ANIMALIA; BACTERIA (MICROORGANISMS); SALMONELLA; SUS SCROFA;

EID: 0032927753     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/5205     Document Type: Article

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