The enhancing effect of the antioxidant N-acetylcysteine on urinary bladder injury induced by dimethylarsinic acid

Toxicologic Pathology

Volumn 39, Issue 7, 2011, Pages 1107-1114

  Takahashi, Naofumi ^a   Yoshida, Toshinori ^a   Ohnuma, Aya ^a   Horiuchi, Haruka ^a   Ishitsuka, Katsumi ^a   Kashimoto, Yukiko ^a   Kuwahara, Maki ^a   Nakashima, Nobuaki ^a   Harada, Takanori ^a  

^a INSTITUTE OF ENVIRONMENTAL TOXICOLOGY   (Japan)

Author keywords

dimethylarsinic acid; ERK signaling; intravesical instillation; N acetylcysteine; oxidative stress; urinary bladder

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; BROXURIDINE; CACODYLIC ACID; PENTOBARBITAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER INJURY; CARCINOGENIC ACTIVITY; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; FISCHER 344 RAT; HISTOPATHOLOGY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; CACODYLIC ACID; CELL PROLIFERATION; FEMALE; IMMUNOHISTOCHEMISTRY; MAP KINASE SIGNALING SYSTEM; OXIDATIVE STRESS; RATS; RATS, INBRED F344; URINARY BLADDER DISEASES; UROTHELIUM;

EID: 82355191819     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623311422076     Document Type: Article

References (33)

1. Aitio M. L.. N-acetylcysteine-passe-partout or much ado about nothing?. Br J Clin Pharmacol. 2006 ; 61: 5-15
2. Aposhian H. V., Zakharyan R. A., Avram M. D., Sampayo-Reyes A., Wollenberg M. L.. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. Toxicol Appl Pharmacol. 2004 ; 198: 327-35 (Pubitemid 38969962)
3. Arnold L. L., Cano M., St John M., Eldan M., van Gemert M., Cohen S. M.. Effects of dietary dimethylarsinic acid on the urine and urothelium of rats. Carcinogenesis. 1999 ; 20: 2171-179 (Pubitemid 29535321)
4. Atmaca G.. Antioxidant effects of sulfur-containing amino acids. Yonsei Med J. 2004 ; 45: 776-88 (Pubitemid 39545364)
5. Chowdhury U. K., Zakharyan R. A., Hernandez A., Avram M. D., Kopplin M. J., Aposhian H. V.. Glutathione-S-transferase-omega [MMA(V) reductase] knockout mice: Enzyme and arsenic species concentrations in tissues after arsenate administration. Toxicol Appl Pharmacol. 2006 ; 216: 446-57 (Pubitemid 44584319)
6. Cohen S. M., Ohnishi T., Arnold L. L., Le X. C.. Arsenic-induced bladder cancer in an animal model. Toxicol Appl Pharmacol. 2007 ; 222: 258-63 (Pubitemid 47198272)
7. Hasegawa R., Furukawa F., Toyoda K., Sato H., Takahashi M., Hayashi Y.. Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats. Jpn J Cancer Res. 1990 ; 81: 483-38
8. Huang Y. C., Hung W. C., Chen W. T., Jiang W. H., Yu H. S., Chai C. Y.. Effects of MEK and DNMT inhibitors on arsenic-treated human uroepithelial cells in relation to Cyclin-D1 and p16. Toxicol Lett. 2011 ; 200: 59-66
9. Guidelines for animal experimentation. Exp Anim. 1987 ; 36: 285-88
10. Kinoshita A., Wanibuchi H., Wei M., Yunoki T., Fukushima S.. Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder. Toxicol Appl Pharmacol. 2007 ; 221: 295-305 (Pubitemid 46855811)
11. Kleinveld H. A., Demacker P. N., Stalenhoef A. F.. Failure of N-acetylcysteine to reduce low-density lipoprotein oxidizability in healthy subjects. Eur J Clin Pharmacol. 1992 ; 43: 639-42
12. Lijinsky W., Thomas B. J., Kovatch R. M.. Systemic and local carcinogenesis by directly acting N-nitroso compounds given to rats by intravesicular administration. Carcinogenesis. 1992 ; 13: 1101-105
13. Luster M. I., Simeonova P. P.. Arsenic and urinary bladder cell proliferation. Toxicol Appl Pharmacol. 2004 ; 198: 419-23 (Pubitemid 38969971)
14. Masutomi N., Toyoda K., Shibutani M., Niho N., Uneyama C., Takahashi N., Hirose M.. Toxic effects of benzyl and allyl isothiocyanates and benzyl-isoform specific metabolites in the urinary bladder after a single intravesical application to rats. Toxicol Pathol. 2001 ; 29: 617-22 (Pubitemid 34032640)
15. Mo L., Zheng X., Huang H. Y., Shapiro E., Lepor H., Cordon-Cardo C., Sun T. T., Wu X. R.. Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis. J Clin Invest. 2007 ; 117: 314-25 (Pubitemid 46203960)
16. Sagristá M. L., García A. E., Africa De Madariaga M., Mora M.. Antioxidant and pro-oxidant effect of the thiolic compounds N-acetyl-L-cysteine and glutathione against free radical-induced lipid peroxidation. Free Radic Res. 2002 ; 36: 329-40 (Pubitemid 35154078)
17. Sakurai T., Ochiai M., Kojima C., Ohta T., Sakurai M. H., Takada N. O., Qu W., Waalkes M. P., Fujiwara K.. Role of glutathione in dimethylarsinic acid-induced apoptosis. Toxicol Appl Pharmacol. 2004 ; 198: 354-65 (Pubitemid 38969965)
18. Salnikow K., Zhitkovich A.. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: Nickel, arsenic and chromium. Chem Res Toxicol. 2008 ; 21: 28-44 (Pubitemid 351219706)
19. Sampayo-Reyes A., Zakharyan R. A., Healy S. M., Aposhian H. V.. Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue. Chem Res Toxicol. 2000 ; 13: 1181-186
20. Shibata M. A., Hasegawa R., Kurata Y., Yamada M., Tamano S., Fukushima S.. Bladder epithelial hyperplasia in F344 rats after intravesical instillation of the antitumor chemotherapeutic agents Adriamycin and mitomycin C. Cancer Lett. 1990 ; 49: 41-9 (Pubitemid 20041127)
21. Suzuki S., Arnold L. L., Pennington K. L., Chen B., Naranmandura H., Le X. C., Cohen S. M.. Dietary administration of sodium arsenite to rats: Relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary bladder epithelium. Toxicol Appl Pharmacol. 2010 ; 244: 99-105
22. Szkudlarek U., Zdziechowski A., Witkowski K., Kasielski M., Luczyska M., Luczyski R., Sarniak A., Nowak D.. Effect of inhaled N-acetylcysteine on hydrogen peroxide exhalation in healthy subjects. Pulm Pharmacol Ther. 2004 ; 17: 155-62 (Pubitemid 38496191)
23. Tapio S., Grosche B.. Arsenic in the aetiology of cancer. Mutat Res. 2006 ; 612: 215-46 (Pubitemid 43767090)
24. Thomas D. J., Waters S. B., Styblo M.. Elucidating the pathway for arsenic methylation. Toxicol Appl Pharmacol. 2004 ; 198: 319-26 (Pubitemid 38969961)
25. Wang A. L., Wang J. P., Wang H., Chen Y. H., Zhao L., Wang L. S., Wei W., Xu D. X.. A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in mice. Hepatol Res. 2006 ; 34: 199-206
26. Wanibuchi H., Yamamoto S., Chen H., Yoshida K., Endo G., Hori T., Fukushima S.. Promoting effects of dimethylarsinic acid on N-butyl-N-(4- hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in rats. Carcinogenesis.. 1996 ; 17: 2435-439
27. Wei M., Arnold L., Cano M., Cohen S. M.. Effects of co-administration of antioxidants and arsenicals on the rat urinary bladder epithelium. Toxicol Sci. 2005 ; 83: 237-45 (Pubitemid 40227893)
28. Wei M., Wanibuchi H., Morimura K., Iwai S., Yoshida K., Endo G., Nakae D., Fukushima S.. Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis. 2002 ; 23: 1387-397
29. Yamamoto S., Konishi Y., Matsuda T., Murai T., Shibata M. A., Matsui-Yuasa I., Otani S., Kuroda K., Endo G., Fukushima S.. Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens. Cancer Res. 1995 ; 55: 1271-276
30. Yamanaka K., Kato K., Mizoi M., An Y., Takabayashi F., Nakano M., Hoshino M., Okada S.. The role of active arsenic species produced by metabolic reduction of dimethylarsinic acid in genotoxicity and tumorigenesis. Toxicol Appl Pharmacol. 2004 ; 198: 385-93 (Pubitemid 38969967)
31. Yamauchi H., Aminaka Y., Yoshida K., Sun G., Pi J., Waalkes M. P.. Evaluation of DNA damage in patients with arsenic poisoning: urinary 8-hydroxydeoxyguanine. Toxicol Appl Pharmacol. 2004 ; 198: 291-96 (Pubitemid 38969958)
32. Yoshida T., Tsutsumi T., Nagata S., Yoshida F., Maita K., Harada T., Ueno Y.. Quantitative analysis of intralobular distribution of microcystin-LR in the mouse liver. J Toxicol Pathol. 2001 ; 14: 205-12 (Pubitemid 33810943)
33. Yoshida T., Yamauchi H., Fan Sun G.. Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol Appl Pharmacol. 2004 ; 198: 243-52 (Pubitemid 38969953)