Quantitative analysis of intralobular distribution of microcystin-LR in the mouse liver

Journal of Toxicologic Pathology

Volumn 14, Issue 3, 2001, Pages 205-212

  Yoshida, Toshinori ^a   Tsutsumi, Tomoaki ^c   Nagata, Satoshi ^c   Yoshida, Fuyuko ^c   Maita, Keizo ^b   Harada, Takanori ^a   Ueno, Yoshio ^c  

^a Insitute of Environmental Toxicology   (Japan)

^b INSTITUTE OF ENVIRONMENTAL TOXICOLOGY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Apoptosis; Image analysis; Immunohistochemistry; Liver; Microcystin LR; Paracentral necrosis

Indexed keywords

EID: 52549087772     PISSN: 09149198     EISSN: 09149198     Source Type: Journal    
DOI: 10.1293/tox.14.205     Document Type: Article

References (36)

1. Chorus I, and Bartram J. editors. Toxic cyanobacteria in water. A Guide to Their Public Health Consequences, Monitoring and Management. London: E & FN Spon, 1999.
2. Hitzfeld BC, Höger SJ, and Dietrich DR. Cyanobacterial toxins: removal during water treatment, and human risk assessment. Environ Health Perspect 2000; 108 (suppl 1): 113-122.
3. Nagata S, Soutome H, Tsutsumi T, Hasegawa A, Sekijima M, Suganuma M, Harada K-I, Suganuma M, and Ueno Y. Novel monoclonal antibodies against microcystin and their protective activity for hepatotoxicity. Nat Toxins 1995; 3: 78-86.
4. Ueno Y, Nagata S, Tsutsumi T, Hasegawa A, Yoshida F, Suttajit M, Mebs D, Pütsch M, and Vasconcelos V. Survey of microcystins in environmental water by a highly sensitive immunoassay based on monoclonal antibody. Nat Toxins 1996; 4: 271-276.
5. Jochimsen EM, Carmichael WW, An J, Cardo DM, Cookson ST, Holmes CEM, de C Antunes MB, de Melo Filho DA, Lyra TM, Barreto VST, Azevedo SMFO, and Jarvis WR. Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. N Eng J Med 1998; 338: 873-878.
6. [Erratum published in N Eng J Med 1998; 339: 139.]
7. Pouria S, de Andrade A, Barbosa J, Cavalcanti RL, Barreto VTS, Ward CJ, Preiser W, Poon GK, Neild GH, and Codd GA. Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil. Lancet 1998; 352: 21-26.
8. 1-initiated rats. Carcinogenesis 1999; 20: 161-165.
9. Ueno Y, Nagata S, Tsutsumi T, Hasegawa A, Watanabe FM, Park H-D, Chen G-C, Chen G, and Yu S-Z. Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haiman and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis 1996; 17: 1317-1321.
10. Toivola DM, Goldman RD, Garrod DR, and Eriksson JE. Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments. J Cell Sci 1997; 110: 23-33.
11. Hooser SB, Beasley VR, Lovell RA, Carmichael WW, and Haschek WM. Toxicity of microcystin LR, a cyclic heptapeptide hepatotoxin from Microcystis aeruginosa, to rats and mice. Vet Pathol 1989; 26: 246-252.
12. Lovell RA, Schaeffer DJ, Hooser SB, Haschek WM, Dahlem AM, Carmichael WW, and Beasley VR. Toxicity of intraperitoneal doses of microcystin-LR in two strains of male mice. J Environ Pathol Toxicol Oncol 1989; 9: 221-238.
13. Theiss WC, Carmichael WW, Wyman J, and Bruner R. Blood pressure and hepatocellular effects of the cyclic heptapeptide toxin produced by the freshwater cyanobacterium (blue-green alga) Microcystis aeruginosa strain PCC-7820. Toxicon 1988; 26: 603-613.
14. Yoshida T, Makita Y, Nagata S, Tsutsumi T, Yoshida F, Sekijima M, Tamura S-I, and Ueno Y. Acute oral toxicity of microcystin-LR, a Cyanobacterial hepatotoxin, in mice. Nat Toxins 1997; 5: 91-95.
15. Yoshida T, Makita Y, Tsutsumi T, Nagata S, Tashiro F, Yoshida F, Sekijima M, Tamura S-I, Harada T, Maita K, and Ueno Y. Immunohistochemical localization of microcystinLR in the liver of mice: a study on the pathogenesis of microcystin-LR-induced hepatotoxicity. Toxicol Pathol 1998; 26: 411-418.
16. Japanese Association for Laboratory Animal Science. Guidelines for animal experimentation. Exp Anim 1987; 36: 285-288.
17. Gavrieli Y, Sherman Y, and Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
18. Kelly WR. The liver and biliary system. In: Pathology of Domestic Animals, 4th ed., KVF Jubb, PC Kennedy, and N Palmer (eds), San Diego: Academic Press Inc., 319-406, 1993.
19. Eriksson JE, Gronberg L, Nygard S, Slotte JP, and Meriluoto JA. Hepatocellular uptake of 3H-dihydromycrocystin-LR, a cyclic peptide toxin. Biochem Biophys Acta 1990; 11: 60-66.
20. Hooser SB, Kuhlenschmidt MS, Dahlem AM, Beasley VR, Carmichael WW, and Haschek WM. Uptake and subcellular localization of tritiated dihydro-microcystin-LR in rat liver. Toxicon 1991; 29: 589-601.
21. Yoshida T, Nakamura Y, Tsutsumi T, Nagata S, Yoshida F, Maita K, Harada T, and Ueno Y. Transmission electron and immunoelectron microscopic studies on microcystin-LRinduced hepatic injuries in mice. J Toxicol Pathol 2001; 14: 157-161.
22. Arnoletti JP, Albo D, Jhala N, Granick MS, Solomon MP, Atkinson B, Rothman VL, and Tuszynski GP. Computer-assisted image analysis of tumor sections for a new thrombospondin receptor. Am J Surg 1994; 168: 433-436.
23. Champelovier P, Seigneurin D, Christophe P, and Kolodie L. Quantification by image analysis of immunohistochemical reactions: application for determination of lysozyme content in individual smeared cells. J Histochem Cytochem 1991; 39: 31-36.
24. Schwartz BR, Pinkus G, Bacus S, Toder M, and Weinberg DS. Cell proliferation in non-Hodgkin's lymphomas. Digital image analysis of Ki-67 antibody staining. Am J Pathol 1989; 134: 327-336.
25. Jonker A, Geerts WJC, Charles R, Lamers WH, and van Noorden CJF. Image analysis and image processing as tools to measure initial rates of enzyme reactions in sections: distribution patterns of glutamate dehydrogenase activity in rat liver lobules. J Histochem Cytochem 1995; 43: 1027-1034.
26. Eriksson JE, and Goldman RD. Protein phosphatase inhibitors alter cytoskeletal structure and cellular morphology. Advan ProtPhosph 1993; 7: 335-357.
27. Solter PF, Wollenberg GK, Huang X, Chu FS, and Runnegar MT. Prolonged sublethal exposure to the protein phosphatase inhibitor microcystin-LR results in multiple dose-dependent hepatotoxic effects. Toxicol Sci 1998; 44: 87-96.
28. Fischer WJ, Hitzfeld BC, Tencalla F, Eriksson JE, Mikhailov A, and Dietrich DR. Microcystin-LR toxicodynamics, induced pathology, and immunohistochemical localization in livers of blue-green algae exposed rainbow trout (Oncorhynchus mykiss). Toxicol Sci 2000; 54: 365-373.
29. Goldsworthy TL, Fransson-Steen R, and Maronpot RR. Importance of and approaches to quantification of hepatocyte apoptosis. Toxicol Pathol 1996; 24: 24-35.
30. Gjertsen BT, and Døskeland SO. Protein phosphorylation in apoptosis. Biochem Biophys Acta 1995; 1269: 187-199.
31. Lin X-H, Walter J, Scheidtmann K, Ohst K, Newport J, and Walter G. Protein phosphatase 2A is required for the initiation of chromosomal DNA replication. Proc Natl Acad Sci USA 1998; 95: 14693-14698.
32. Ikeda K, Kinoshita H, Hirohashi K, Kubo S, and Kaneda K. The ultrastructure, kinetics and intralobular distribution of apoptotic hepatocytes after portal branch ligation with special reference to their relationship to necrotic hepatocytes. Arch Histol Cytol 1995; 58: 171-184.
33. Miyazawa Y, Tsutsui H, Mizuhara H, Fujiwara H, and Kaneda K. Involvement of intrasinusoidal hemostasis in the development of concanavalin A-induced hepatic injury in mice. Hepatology 1997; 27: 497-506.
34. Fausto N. Liver regeneration. J Hepatol 2000; 32 (Suppl 1): 19-31.
35. Nakano Y, Shirai M, Mori N, and Nakano M. Neutralization of microcystin shock in mice by tumor necrosis factor alpha antiserum. Appl Environ Microbiol 1991; 57: 327-330.
36. Sueoka E, Sueoka N, Okabe S, Kozu T, Komori A, Ohta T, Suganuma M, Kim SJ, Lim IK, and Fujiki H. Expression of the tumor necrosis factor a gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes. J Cancer Res Clin Oncol 1997; 123: 413-419.