In vivo microdialysis and electroencephalographic activity in freely moving guinea pigs exposed to organophosphorus nerve agents sarin and VX: Analysis of acetylcholine and glutamate

Archives of Toxicology

Volumn 85, Issue 12, 2011, Pages 1607-1616

  O'Donnell, John C ^a   McDonough, John H ^a   Shih, Tsung Ming ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Aminobutylic acid (GABA); Acetylcholine; Acetylcholinesterase; Choline; Electroencephalogram; Glutamate; Guinea pig; In vivo microdialysis; Nerve agents; Organophosphorus compounds; Sarin; Seizure activity; VX

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; ASPARTIC ACID; GLUTAMIC ACID; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; SARIN;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ACETYLCHOLINE BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROENCEPHALOGRAPHY; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LETHALITY; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; SEIZURE;

ACETYLCHOLINE; ANIMALS; BRAIN; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROENCEPHALOGRAPHY; GLUTAMIC ACID; GUINEA PIGS; MALE; MICRODIALYSIS; MULTIVARIATE ANALYSIS; ORGANOTHIOPHOSPHORUS COMPOUNDS; SARIN; SEIZURES; SEVERITY OF ILLNESS INDEX;

CAVIA;

EID: 82355169839     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0724-z     Document Type: Article

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