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Volumn 152, Issue 12, 2011, Pages 4882-4893

Noninvasive analytical estimation of endogenous GnRH drive: Analysis using graded competitive GnRH-receptor antagonism and a calibrating pulse of exogenous GnRH

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ESTRADIOL; GANIRELIX; GONADORELIN; GONADORELIN RECEPTOR; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

EID: 82355165077     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1461     Document Type: Article
Times cited : (16)

References (62)
  • 1
    • 0023954666 scopus 로고
    • Contemporary aspects of discrete peak detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men
    • Urban RJ, Evans WS, Rogol AD, Kaiser DL, Johnson ML, Veldhuis JD 1988 Contemporary aspects of discrete peak detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men. Endocr Rev 9:3-37
    • (1988) Endocr Rev , vol.9 , pp. 3-37
    • Urban, R.J.1    Evans, W.S.2    Rogol, A.D.3    Kaiser, D.L.4    Johnson, M.L.5    Veldhuis, J.D.6
  • 2
    • 57349192792 scopus 로고    scopus 로고
    • Motivations and methods for analyzing pulsatile hormone secretion
    • Veldhuis JD, Keenan DM, Pincus SM 2008 Motivations and methods for analyzing pulsatile hormone secretion. Endocr Rev 29:823-864
    • (2008) Endocr Rev , vol.29 , pp. 823-864
    • Veldhuis, J.D.1    Keenan, D.M.2    Pincus, S.M.3
  • 6
    • 0016749899 scopus 로고
    • Effect of castration on luteinizing hormone and luteinizing hormone releasing hormone in the male rat
    • Shin SH, Howitt C 1975 Effect of castration on luteinizing hormone and luteinizing hormone releasing hormone in the male rat. J Endocrinol 65:447-448
    • (1975) J Endocrinol , vol.65 , pp. 447-448
    • Shin, S.H.1    Howitt, C.2
  • 7
    • 0021415323 scopus 로고
    • Orchidectomy unleashes pulsatile luteinizing hormone secretion in the rat
    • Ellis GB, Desjardins C 1984 Orchidectomy unleashes pulsatile luteinizing hormone secretion in the rat. Bio Reprod 30:619-627
    • (1984) Bio Reprod , vol.30 , pp. 619-627
    • Ellis, G.B.1    Desjardins, C.2
  • 8
    • 0026682730 scopus 로고
    • Evidence that androgen negative-feedback regulates hypothalamic GnRH impulse strength and the burst-like secretion of biologically active luteinizing hormone in men
    • Veldhuis JD, Urban RJ, Dufau ML 1992 Evidence that androgen negative-feedback regulates hypothalamic GnRH impulse strength and the burst-like secretion of biologically active luteinizing hormone in men. J Clin Endocrinol Metab 74:1227-1235
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 1227-1235
    • Veldhuis, J.D.1    Urban, R.J.2    Dufau, M.L.3
  • 9
    • 0035113428 scopus 로고    scopus 로고
    • Negative feedback regulation of the secretion and actions of gonadotropin-releasing hormone in males
    • Tilbrook AJ, Clarke IJ 2001 Negative feedback regulation of the secretion and actions of gonadotropin-releasing hormone in males. Biol Reprod 64:735-742 (Pubitemid 32174042)
    • (2001) Biology of Reproduction , vol.64 , Issue.3 , pp. 735-742
    • Tilbrook, A.J.1    Clarke, I.J.2
  • 10
    • 0036842223 scopus 로고    scopus 로고
    • Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: Membrane versus nuclear receptor activation
    • DOI 10.1210/me.2002-0011
    • Shakil T, Hoque AN, Husain M, Belsham DD 2002 Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: membrane versus nuclear receptor activation. Mol Endocrinol 16:2592-2602 (Pubitemid 35266077)
    • (2002) Molecular Endocrinology , vol.16 , Issue.11 , pp. 2592-2602
    • Shakil, T.1    Ehsanul, H.A.N.2    Husain, M.3    Belsham, D.D.4
  • 11
    • 0025807157 scopus 로고
    • Testosterone inhibits gonadotropin-releasing hormone pulse frequency in the male sheep
    • Jackson GL, Kuehl D, Rhim TJ 1991 Testosterone inhibits gonadotropin-releasing hormone pulse frequency in the male sheep. Bio Reprod 45:188-194
    • (1991) Bio Reprod , vol.45 , pp. 188-194
    • Jackson, G.L.1    Kuehl, D.2    Rhim, T.J.3
  • 12
    • 0028107460 scopus 로고
    • Androgen-receptor blockade enhances pulsatile luteinizing hormone production in late pubertal males: Evidence for a hypothalamic site of physiologic androgen feedback action
    • Kerrigan JR, Veldhuis JD, Rogol AD 1994 Androgen-receptor blockade enhances pulsatile luteinizing hormone production in late pubertal males: evidence for a hypothalamic site of physiological androgen feedback action. Pediatr Res 35:102-106 (Pubitemid 24004643)
    • (1994) Pediatric Research , vol.35 , Issue.1 , pp. 102-106
    • Kerrigan, J.R.1    Veldhuis, J.D.2    Rogol, A.D.3
  • 14
    • 0021713004 scopus 로고
    • The gonadotropin-suppressive activity of androgen is increased in elderly men
    • DOI 10.1016/0026-0495(84)90237-3
    • Winters SJ, Sherins RJ, Troen P 1984 The gonadotropin-suppressive activity of androgen is increased in elderly men. Metabolism 33:1052-1059 (Pubitemid 15210842)
    • (1984) Metabolism: Clinical and Experimental , vol.33 , Issue.11 , pp. 1052-1059
    • Winters, S.J.1    Sherins, R.J.2    Troen, P.3
  • 15
    • 0030723197 scopus 로고    scopus 로고
    • Aging alters feedforward and feedback linkages between LH and testosterone in healthy men
    • Mulligan T, Iranmanesh A, Johnson ML, Straume M, Veldhuis JD 1997 Aging alters feedforward and feedback linkages between LH and testosterone in healthy men. Am J Physiol 273:R1407-R1413
    • (1997) Am J Physiol , vol.273
    • Mulligan, T.1    Iranmanesh, A.2    Johnson, M.L.3    Straume, M.4    Veldhuis, J.D.5
  • 16
    • 0019350631 scopus 로고
    • Age-related changes in the feedback regulation of gonadotrophin secretion by sex steroids in men
    • Muta K, Kato K, Akamine Y, Ibayashi H 1981 Age-related changes in the feedback regulation of gonadotrophin secretion by sex steroids in men. Acta Endocrinol 96:154-162 (Pubitemid 11181538)
    • (1981) Acta Endocrinologica , vol.96 , Issue.2 , pp. 154-162
    • Muta, K.1    Kato, K.2    Akamine, Y.3    Ibayashi, H.4
  • 17
    • 0023143155 scopus 로고
    • Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men
    • Deslypere JP, Kaufman JM, Vermeulen T, Vogelaers D, Vandalem JL, Vermeulen A 1987 Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J Clin Endocrinol Metab 64:68-73 (Pubitemid 17015880)
    • (1987) Journal of Clinical Endocrinology and Metabolism , vol.64 , Issue.1 , pp. 68-73
    • Deslypere, J.P.1    Kaufman, J.M.2    Vermeulen, T.3
  • 18
    • 8744234066 scopus 로고    scopus 로고
    • Erosion of endogenous testosterone-driven negative feedback on pulsatile luteinizing hormone secretion in healthy aging men
    • DOI 10.1210/jc.2004-0399
    • Veldhuis JD, Iranmanesh A, Keenan DM 2004 Erosion of endogenous testosterone-driven negative feedback on pulsatile LH secretion in healthy aging men. J Clin Endocrinol Metab 89:5753-5761 (Pubitemid 39518468)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.11 , pp. 5753-5761
    • Veldhuis, J.D.1    Iranmanesh, A.2    Keenan, D.M.3
  • 19
    • 33749561819 scopus 로고    scopus 로고
    • Age or factors associated with aging attenuate testosterone's concentration-dependent enhancement of the regularity of luteinizing hormone secretion in healthy men
    • DOI 10.1210/jc.2005-2811
    • Liu PY, Takahashi PY, Roebuck PD, Veldhuis JD 2006 Age or factors associated with aging attenuate testosterone's concentration-dependent enhancement of the regularity of luteinizing hormone secretion in healthy men. J Clin Endocrinol Metab 91:4077-4084 (Pubitemid 44536888)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.10 , pp. 4077-4084
    • Liu, P.Y.1    Takahashi, P.Y.2    Roebuck, P.D.3    Veldhuis, J.D.4
  • 20
    • 0020211729 scopus 로고
    • The temporal relationship between gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes
    • Clarke IJ, Cummins JT 1982 The temporal relationship between gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 111:1737-1739
    • (1982) Endocrinology , vol.111 , pp. 1737-1739
    • Clarke, I.J.1    Cummins, J.T.2
  • 21
    • 33644876582 scopus 로고    scopus 로고
    • Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: Analyses via a model of graded GnRH receptor blockade
    • Liu PY, Pincus SM, Takahashi PY, Roebuck PD, Iranmanesh A, Keenan DM, Veldhuis JD 2006 Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade. Am J Physiol 290:E34-E41
    • (2006) Am J Physiol , vol.290
    • Liu, P.Y.1    Pincus, S.M.2    Takahashi, P.Y.3    Roebuck, P.D.4    Iranmanesh, A.5    Keenan, D.M.6    Veldhuis, J.D.7
  • 22
    • 0024523047 scopus 로고
    • The nature of the gonadotropin-releasing hormone stimulus-luteinizing hormone secretory response of human gonadotrophs in vivo
    • Veldhuis JD, O'Dea LS, Johnson ML 1989 The nature of the gonadotropin-releasing hormone stimulus-luteinizing hormone secretory response of human gonadotrophs in vivo. J Clin Endocrinol Metab 68:661-670 (Pubitemid 19081444)
    • (1989) Journal of Clinical Endocrinology and Metabolism , vol.68 , Issue.3 , pp. 661-670
    • Veldhuis, J.D.1    O'Dea, L.S.L.2    Johnson, M.L.3
  • 23
    • 0029856760 scopus 로고    scopus 로고
    • Contrasts in the gonadotropin-releasing hormone dose-response relationships for luteinizing hormone, follicle-stimulating hormone and α-subunit release in young versus older men: Appraisal with high-specificity immunoradiometric assay and deconvolution analysis
    • Zwart AD, Urban RJ, Odell WD, Veldhuis JD 1996 Contrasts in the gonadotropin-releasing dose-response relationships for luteinizing hormone, follicle-stimulating hormone, and α-subunit release in young versus older men: appraisal with high-specificity immunoradiometric assay and deconvolution analysis. Eur J Endocrinol 135:399-406 (Pubitemid 26364939)
    • (1996) European Journal of Endocrinology , vol.135 , Issue.4 , pp. 399-406
    • Zwart, A.D.1    Urban, R.J.2    Odell, W.D.3    Veldhuis, J.D.4
  • 24
    • 0030937284 scopus 로고    scopus 로고
    • Molecular mechanisms of ligand interaction with the gonadotropin- releasing hormone receptor
    • DOI 10.1210/er.18.2.180
    • Sealfon SC, Weinstein H, Millar RP 1997 Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor. Endocr Rev 18:180-205 (Pubitemid 27171519)
    • (1997) Endocrine Reviews , vol.18 , Issue.2 , pp. 180-205
    • Sealfon, S.C.1    Weinstein, H.2    Millar, R.P.3
  • 26
    • 55449095322 scopus 로고    scopus 로고
    • Probabilistic recovery of pulsatile, secretory and kinetic structure: An alternating discrete and continuous schema
    • Chattopadhyay S, Veldhuis JD, Keenan DM 2008 Probabilistic recovery of pulsatile, secretory and kinetic structure: an alternating discrete and continuous schema. Quarterly Appl Math 66:401-421
    • (2008) Quarterly Appl Math , vol.66 , pp. 401-421
    • Chattopadhyay, S.1    Veldhuis, J.D.2    Keenan, D.M.3
  • 27
    • 0020417830 scopus 로고
    • Calculation of free and bound fractions of testosterone and estradiol-17beta to human plasma proteins at body temperature
    • DOI 10.1016/0022-4731(82)90038-3
    • Sodergard R, Backstrom T, Shanbhag V, Carstensen H 1982 Calculation of free and bound fractions of testosterone and estradiol-17 β to human plasma proteins at body temperature. J Steroid Biochem Mol Biol 16:801-810 (Pubitemid 13228095)
    • (1982) Journal of Steroid Biochemistry , vol.16 , Issue.6 , pp. 801-810
    • Sodergard, R.1    Backstrom, T.2    Shanbhag, V.3    Carstensen, H.4
  • 29
    • 18844415053 scopus 로고    scopus 로고
    • Graded inhibition of pulsatile luteinizing hormone secretion by a selective gonadotropin-releasing hormone (GnRH)-receptor antagonist in healthy men: Evidence that age attenuates hypothalamic GnRH outflow
    • DOI 10.1210/jc.2004-2521
    • Takahashi PY, Liu PY, Roebuck PD, Iranmanesh A, Veldhuis JD 2005 Graded inhibition of pulsatile LH secretion by a selective GnRH-receptor antagonist in healthy men: evidence that age attenuates hypothalamic GnRH outflow. J Clin Endocrinol Metab 90:2768-2774 (Pubitemid 40686322)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.5 , pp. 2768-2774
    • Takahashi, P.Y.1    Liu, P.Y.2    Roebuck, P.D.3    Iranmanesh, A.4    Veldhuis, J.D.5
  • 30
    • 0034146307 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of testosterone and luteinizing hormone suppression by cetrorelix in healthy volunteers
    • Pechstein B, Nagaraja NV, Hermann R, Romeis P, Locher M, Derendorf H 2000 Pharmacokinetic-pharmacodynamic modeling of testosterone and luteinizing hormone suppression by cetrorelix in healthy volunteers. J Clin Pharmacol 40:266-274
    • (2000) J Clin Pharmacol , vol.40 , pp. 266-274
    • Pechstein, B.1    Nagaraja, N.V.2    Hermann, R.3    Romeis, P.4    Locher, M.5    Derendorf, H.6
  • 32
    • 18844385311 scopus 로고    scopus 로고
    • Mathematical modeling of receptor-mediated interlinked systems
    • San Diego: Academic Press
    • Keenan DM, Veldhuis JD 2003 Mathematical modeling of receptor-mediated interlinked systems. Encyclopedia of hormones. San Diego: Academic Press; 286-294
    • (2003) Encyclopedia of Hormones , pp. 286-294
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 33
    • 84932928337 scopus 로고
    • On the theory of mortality measurement, I
    • Grenander U 1956 On the theory of mortality measurement, I. Skand Aktuarietidskrift 39:70-96
    • (1956) Skand Aktuarietidskrift , vol.39 , pp. 70-96
    • Grenander, U.1
  • 34
    • 0021259167 scopus 로고
    • Role of endogenous opiates in the expression of negative feedback actions of androgen and estrogen on pulsatile properties of luteinizing hormone secretion in man
    • Veldhuis JD, Rogol AD, Samojlik E, Ertel NH 1984 Role of endogenous opiates in the expression of negative feedback actions of estrogen and androgen on pulsatile properties of luteinizing hormone secretion in man. J Clin Invest 74:47-55 (Pubitemid 14086043)
    • (1984) Journal of Clinical Investigation , vol.74 , Issue.1 , pp. 47-55
    • Veldhuis, J.D.1    Rogol, A.D.2    Samojlik, E.3    Ertel, N.H.4
  • 35
    • 13444251303 scopus 로고    scopus 로고
    • Sex differences in the distribution and abundance of androgen receptor mRNA-containing cells in the preoptic area and hypothalamus of the ram and ewe
    • DOI 10.1111/j.1365-2826.2005.01261.x
    • Scott CJ, Clarke IJ, Rao A, Tilbrook AJ 2004 Sex differences in the distribution and abundance of androgen receptor mRNA-containing cells in the preoptic area and hypothalamus of the ram and ewe. J Neuroendocrinol 16:956-963 (Pubitemid 40214440)
    • (2004) Journal of Neuroendocrinology , vol.16 , Issue.12 , pp. 956-963
    • Scott, C.J.1    Clarke, I.J.2    Rao, A.3    Tilbrook, A.J.4
  • 36
    • 0033305253 scopus 로고    scopus 로고
    • Regulation of lutenizing hormone secretion and subunit messenger ribonucleic acid expression by gonadal steroids in perifused pituitary cells from male monkeys and rats
    • Kawakami S, Winters SJ 1999 Regulation of lutenizing hormone secretion and subunit messenger ribonucleic acid expression by gonadal steroids in perifused pituitary cells from male monkeys and rats. Endocrinology 140:3587-3593 (Pubitemid 30648841)
    • (1999) Endocrinology , vol.140 , Issue.8 , pp. 3587-3593
    • Kawakami, S.1    Winters, S.J.2
  • 37
    • 0034976485 scopus 로고    scopus 로고
    • Aromatization mediates testosterone's short-term feedback restraint of 24-hour endogenously driven and acute exogenous gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone secretion in young men
    • DOI 10.1210/jc.86.6.2600
    • Schnorr JA, Bray MJ, Veldhuis JD 2001 Aromatization mediates testosterone's short-term feedback restraint of 24-hour endogenously driven and acute exogenous GnRH-stimulated LH and FSH secretion in young men. J Clin Endocrinol Metab 86:2600-2606 (Pubitemid 32545712)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.6 , pp. 2600-2606
    • Schnorr, J.A.1    Bray, M.J.2    Veldhuis, J.D.3
  • 38
    • 0030974289 scopus 로고    scopus 로고
    • Regulation of preoptic area gonadotrophin-releasing hormone (GnRH) mRNA expression by gonadal steroids in the long-term gonadectomized male rat
    • DOI 10.1016/S0169-328X(97)00037-5, PII S0169328X97000375
    • Spratt DP, Herbison AE 1997 Regulation of preoptic area gonadotrophin-releasing hormone (GnRH)mRNAexpression by gonadal steroids in the long-term gonadectomized male rat. Brain Res Mol Brain Res 47:125-133 (Pubitemid 27268267)
    • (1997) Molecular Brain Research , vol.47 , Issue.1-2 , pp. 125-133
    • Spratt, D.P.1    Herbison, A.E.2
  • 40
    • 0031738481 scopus 로고    scopus 로고
    • Regulation of gonadotropin-releasing hormone (GnRH) gene expression by 5α-dihydrotestosterone in GnRH-secreting GT1-7 hypothalamic neurons
    • DOI 10.1210/en.139.3.1108
    • Belsham DD, Evangelou A, Roy D, Duc VL, Brown TJ 1998 Regulation of gonadotropin-releasing hormone (GnRH) gene expression by 5 α- dihydrotestosterone in GnRH-secreting GT1-7 hypothalamic neurons. Endocrinology 139:1108-1114 (Pubitemid 28510129)
    • (1998) Endocrinology , vol.139 , Issue.3 , pp. 1108-1114
    • Belsham, D.D.1    Evangelou, A.2    Roy, D.3    Le, D.V.4    Brown, T.J.5
  • 42
    • 12244291904 scopus 로고    scopus 로고
    • Age and testosterone feedback jointly control the dose-dependent actions of gonadotropin-releasing hormone in healthy men
    • DOI 10.1210/jc.2004-1313
    • Veldhuis JD, Iranmanesh A, Mulligan T 2005 Age and testosterone feedback jointly control the dose-dependent actions of gonadotropin-releasing hormone in healthy men. J Clin Endocrinol Metab 90:302-309 (Pubitemid 40116672)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.1 , pp. 302-309
    • Veldhuis, J.D.1    Iranmanesh, A.2    Mulligan, T.3
  • 44
    • 34548820963 scopus 로고    scopus 로고
    • ATP channels that are regulated by estrogen and responsive to glucose and metabolic inhibition
    • DOI 10.1523/JNEUROSCI.1657-07.2007
    • Zhang C, Bosch MA, Levine JE, Rønnekleiv OK, Kelly MJ 2007 Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition. J Neurosci 27:10153-10164 (Pubitemid 47450463)
    • (2007) Journal of Neuroscience , vol.27 , Issue.38 , pp. 10153-10164
    • Zhang, C.1    Bosch, M.A.2    Levine, J.E.3    Ronnekleiv, O.K.4    Kelly, M.J.5
  • 45
    • 61449135038 scopus 로고    scopus 로고
    • Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons
    • Noel SD, Keen KL, Baumann DI, Filardo EJ, Terasawa E 2009 Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons. Mol Endocrinol 23:349-359
    • (2009) Mol Endocrinol , vol.23 , pp. 349-359
    • Noel, S.D.1    Keen, K.L.2    Baumann, D.I.3    Filardo, E.J.4    Terasawa, E.5
  • 47
    • 0015806483 scopus 로고
    • Reduced high affinity 5 α-dihydrotestosterone receptor capacity in the ventral prostate of the aging rat
    • Shain SA, Axelrod LR 1973 Reduced high affinity 5 α- dihydrotestosterone receptor capacity in the ventral prostate of the aging rat. Steroids 21:801-812
    • (1973) Steroids , vol.21 , pp. 801-812
    • Shain, S.A.1    Axelrod, L.R.2
  • 48
    • 0019365556 scopus 로고
    • Age-related changes in the concentrations of cytosol receptors for sex steroid hormones in the hypothalamus and pituitary gland of the rat
    • DOI 10.1016/0006-8993(81)90596-5
    • Haji M, Kato KI, Nawata H, Ibayashi H 1981 Age-related changes in the concentrations of cytosol receptors for sex steroid hormones in the hypothalamus and pituitary gland of the rat. Brain Res 204:373-386 (Pubitemid 11205708)
    • (1981) Brain Research , vol.204 , Issue.2 , pp. 373-386
    • Haji, M.1    Kato, K.2    Nawata, H.3    Ibayashi, H.4
  • 49
    • 0019138184 scopus 로고
    • Identification, partial characterization and age-related changes of a cytoplasmic androgen receptor in the rat penis
    • DOI 10.1016/0022-4731(80)90064-3
    • Rajfer J, Namkung PC, Petra PH 1980 Identification, partial characterization and age-related changes of a cytoplasmic androgen receptor in the rat penis. J Steroid Biochem 13:1489-1492 (Pubitemid 11176378)
    • (1980) Journal of Steroid Biochemistry , vol.13 , Issue.12 , pp. 1489-1492
    • Rajfer, J.1    Namkung, P.C.2    Petra, P.H.3
  • 50
    • 0028835523 scopus 로고
    • Age-related alterations in tanycytes of the mediobasal hypothalamus of the male rat
    • Zoli M, Ferraguti F, Frasoldati A, Biagini G, Agnati LF 1995 Age-related alterations in tanycytes of the mediobasal hypothalamus of the male rat. Neurobiol Aging 16:77-83
    • (1995) Neurobiol Aging , vol.16 , pp. 77-83
    • Zoli, M.1    Ferraguti, F.2    Frasoldati, A.3    Biagini, G.4    Agnati, L.F.5
  • 51
    • 71949105167 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone neuroterminals and their microenvironment in the median eminence: Effects of aging and estradiol treatment
    • Yin W, Wu D, Noel ML, Gore AC 2009 Gonadotropin-releasing hormone neuroterminals and their microenvironment in the median eminence: effects of aging and estradiol treatment. Endocrinology 150:5498-5508
    • (2009) Endocrinology , vol.150 , pp. 5498-5508
    • Yin, W.1    Wu, D.2    Noel, M.L.3    Gore, A.C.4
  • 52
    • 0027976388 scopus 로고
    • Opioidergic modulation of N-methyl-D,L-aspartic-acid-stimulated LH release in young adult but not older male mice
    • Miller GM, Gibson MJ 1994 Opioidergic modulation of N-methyl-D,L- aspartic-acid-stimulated LH release in young adult but not older male mice. Neuroendocrinol 59:277-284 (Pubitemid 24053264)
    • (1994) Neuroendocrinology , vol.59 , Issue.3 , pp. 277-284
    • Miller, G.H.1    Gibson, M.J.2
  • 53
    • 0032879225 scopus 로고    scopus 로고
    • Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig cell) defects in the healthy aging male gonadotropic axis
    • DOI 10.1530/eje.0.1410257
    • Mulligan T, Iranmanesh A, Kerzner R, Demers LW, Veldhuis JD 1999 Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig-cell) defects in the healthy aging male gonadotropic axis. Eur J Endocrinol 141:257-266 (Pubitemid 29465931)
    • (1999) European Journal of Endocrinology , vol.141 , Issue.3 , pp. 257-266
    • Mulligan, T.1    Iranmanesh, A.2    Kerzner, R.3    Demers, L.W.4    Veldhuis, J.D.5
  • 54
    • 77954463584 scopus 로고    scopus 로고
    • Age in men does not determine GnRH's dose-dependent stimulation of luteinizing hormone secretion under an exogenous testosterone clamp
    • Iranmanesh A, Mulligan T, Veldhuis JD 2010 Age in men does not determine GnRH's dose-dependent stimulation of luteinizing hormone secretion under an exogenous testosterone clamp. J Clin Endocrinol Metab 95:2877-2884
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2877-2884
    • Iranmanesh, A.1    Mulligan, T.2    Veldhuis, J.D.3
  • 55
    • 4644344715 scopus 로고    scopus 로고
    • Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta)
    • DOI 10.1210/en.2004-0379
    • Gore AC, Windsor-Engnell BM, Terasawa E 2004 Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta). Endocrinology 145:4653-4659 (Pubitemid 39281458)
    • (2004) Endocrinology , vol.145 , Issue.10 , pp. 4653-4659
    • Gore, A.C.1    Windsor-Engnell, B.M.2    Terasawa, E.3
  • 56
    • 0024580290 scopus 로고
    • Alterations in luteinizing hormone-releasing hormone release from the mediobasal hypothalamus of ovariectomized, steroid-primed middle-aged rats as measured by push-pull perfusion
    • Rubin BS, Bridges RS 1989 Alterations in luteinizing hormone-releasing hormone release from the mediobasal hypothalamus of ovariectomized, steroid-primed middle-aged rats as measured by push-pull perfusion. Neuroendocrinol 49:225-232 (Pubitemid 19095260)
    • (1989) Neuroendocrinology , vol.49 , Issue.3 , pp. 225-232
    • Rubin, B.S.1    Bridges, R.S.2
  • 57
    • 0024430817 scopus 로고
    • The free hormone hypothesis: A physiologically based mathematical model
    • Mendel CM 1989 The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev 10:232-274 (Pubitemid 19223060)
    • (1989) Endocrine Reviews , vol.10 , Issue.3 , pp. 232-274
    • Mendel, C.M.1
  • 58
    • 0023841615 scopus 로고
    • Effects of aging on pituitary and testicular luteinizing hormone-releasing hormone receptors in the rat
    • DOI 10.1016/0024-3205(88)90643-1
    • Limonta P, Dondi D, Maggi R, Martini L, Piva F 1988 Effects of aging on pituitary and testicular luteinizing hormone-releasing hormone receptors in the rat. Life Sci 42:335-342 (Pubitemid 18038336)
    • (1988) Life Sciences , vol.42 , Issue.3 , pp. 335-342
    • Limonta, P.1    Dondi, D.2    Maggi, R.3    Martini, L.4    Piva, F.5
  • 59
    • 0021326516 scopus 로고
    • Decreased ability of old male rats to secrete luteinizing hormone (LH) is not due to alterations in pituitary LH-releasing hormone receptors
    • Sonntag WE, Forman LJ, Fiori JM, Hylka VW, Meites J 1984 Decreased ability of old male rats to secrete luteinizing hormone (LH) is not due to alterations in pituitary LH-releasing hormone receptors. Endocrinology 114:1657-1664 (Pubitemid 14140317)
    • (1984) Endocrinology , vol.114 , Issue.5 , pp. 1657-1664
    • Sonntag, W.E.1    Forman, L.J.2    Fiori, J.M.3
  • 60
    • 54949089956 scopus 로고    scopus 로고
    • Forebrain steroid levels fluctuate rapidly during social interactions
    • Remage-Healey L, Maidment NT, Schlinger BA 2008 Forebrain steroid levels fluctuate rapidly during social interactions. Nat Neurosci 11:1327-1334
    • (2008) Nat Neurosci , vol.11 , pp. 1327-1334
    • Remage-Healey, L.1    Maidment, N.T.2    Schlinger, B.A.3
  • 61
    • 23844481788 scopus 로고    scopus 로고
    • Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: Evidence for ligand-selective, receptor-active conformations
    • DOI 10.1074/jbc.M413520200
    • Lu ZL, Gallagher R, Sellar R, Coetsee M, Millar RP 2005 Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: evidence for ligand-selective, receptoractive conformations. J Biol Chem 280:29796-29803 (Pubitemid 41177057)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.33 , pp. 29796-29803
    • Lu, Z.-L.1    Gallagher, R.2    Sellar, R.3    Coetsee, M.4    Millar, R.P.5
  • 62
    • 0000311157 scopus 로고
    • On the theory of mortality measurement, II
    • Grenander U 1957 On the theory of mortality measurement, II. Skand Aktuarietidskrift 39:125-153
    • (1957) Skand Aktuarietidskrift , vol.39 , pp. 125-153
    • Grenander, U.1


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