Erosion of endogenous testosterone-driven negative feedback on pulsatile luteinizing hormone secretion in healthy aging men

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 11, 2004, Pages 5753-5761

  Veldhuis, Johannes D ^a   Iranmanesh, Ali ^b   Keenan, Daniel M ^c  

^a MAYO CLINIC   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE BINDING PROTEIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADULT; AGED; AGING; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; LUTEINIZING HORMONE RELEASE; MALE; NEGATIVE FEEDBACK; NORMAL HUMAN; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE; TESTOSTERONE RELEASE;

ADOLESCENT; ADULT; AGED; AGING; FEEDBACK; HUMANS; LUTEINIZING HORMONE; MALE; MIDDLE AGED; TESTOSTERONE;

ILEX COOKII;

EID: 8744234066     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0399     Document Type: Article

References (41)

1. Urban RJ, Evans WS, Rogol AD, Kaiser DL, Johnson ML, Veldhuis JD 1988 Contemporary aspects of discrete peak detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men. Endocr Rev 9:3-37
2. Baker HWG, Burger HG, de Kretser DM, Hudson B, O'Connor S, Wang C, Mirovics A, Court J, Dunlop M, Rennie GC 1976 Changes in the pituitary-testicular system with age. Clin Endocrinol (Oxf) 5:349-372
3. Morley JE, Kaiser F, Raum WJ, Perry 3rd HM, Flood JF, Jensen J, Silver AJ, Roberts E 1997 Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor I to growth hormone. Proc Natl Acad Sci USA 94:7537-7542
4. Winters SJ, Troen P 1982 Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion. J Clin Endocrinol Metab 55:560-565
5. Vermeulen A, Deslypere JP, De Meirleir K 1989 A new look at the andropause: altered function of the gonadotrophs. J Steroid Biochem 32:163-165
6. Mitchell R, Hollis S, Rothwell C, Robertson WR 1995 Age-related changes in the pituitary-testicular axis in normal men; lower serum testosterone results from decreased bioactive LH drive. Clin Endocrinol (Oxf) 42:501-507
7. Veldhuis JD, Johnson ML, Keenan D, Iranmanesh A 2003 The ensemble male hypothalamo-pituitary-gonadal axis. In: Timiras PS, ed. Physiological basis of aging and geriatrics. 3rd ed. Boca Raton, FL: CRC Press; 213-231
8. Pincus SM 1991 Approximate entropy as a measure of system complexity. Proc Natl Acad Sci USA 88:2297-2301
9. Pincus SM, Mulligan T, Iranmanesh A, Gheorghiu S, Godschalk M, Veldhuis JD 1996 Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males. Proc Natl Acad Sci USA 93:14100-14105
10. Keenan DM, Veldhuis JD 2001 Hypothesis testing of the aging male gonadal axis via a biomathematical construct. Am J Physiol 280:R1755-R1771
11. Keenan DM, Veldhuis JD 2001 Disruption of the hypothalamic luteinizing-hormone pulsing mechanism in aging men. Am J Physiol 281:R1917-R1924
12. Veldhuis JD, Urban RJ, Lizarralde G, Johnson ML, Iranmanesh A 1992 Attenuation of luteinizing hormone secretory burst amplitude is a proximate basis for the hypoandrogenism of healthy aging in men. J Clin Endocrinol Metab 75:52-58
13. Mulligan T, Iranmanesh A, Kerzner R, Demers LW, Veldhuis JD 1999 Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig-cell) defects in the healthy aging male gonadotropic axis. Eur J Endocrinol 141:257-266
14. Keenan DM, Veldhuis JD 1998 A biomathematical model of time-delayed feedback in the human male hypothalamic-piruitary-Leydig cell axis. Am J Physiol 275:E157-E176
15. Keenan DM, Sun W, Veldhuis JD 2000 A stochastic biomathematical model of the male reproductive hormone system. SIAM J Appl Math 61:934-965
16. Keenan DM, Veldhuis JD, Yang R 1998 Joint recovery of pulsatile and basal hormone secretion by stochastic nonlinear random-effects analysis. Am J Physiol 275:R1939-R1949
17. Keenan DM, Veldhuis JD 2000 Explicating hypergonadotropism in post-menopausal women: a statistical model. Am J Physiol 278:R1247-R1257
18. Keenan DM, Alexander SL, Irvine CHG, Clarke IJ, Canny BJ, Scott CJ, Tilbrook AJ, Turner AI, Veldhuis JD 2004 Reconstruction of in vivo time-evolving neuroendocrine dose-response properties unveils admixed deterministic and stochastic elements in interglandular signaling. Proc Natl Acad Sci USA 101:6740-6745
19. Veldhuis JD, King JC, Urban RJ, Rogol AD, Evans WS, Kolp LA, Johnson ML 1987 Operating characteristics of the male hypothalamo-pituitary-gonadal axis: pulsatile release of testosterone and follicle-stimulating hormone and their temporal coupling with luteinizing hormone. J Clin Endocrinol Metab 65:929-941
20. Veldhuis JD, Evans WS, Kolp LA, Rogol AD, Johnson ML 1988 Physiological profiles of episodic progesterone release during the mid-luteal phase of the human menstrual cycle: analysis of circadian and ultradian rhythms, discrete pulse properties, and correlations with simultaneous LH release. J Clin Endocrinol Metab 66:414-421
21. Veldhuis JD, Johnson ML, Faunt LM, Seneta E 1994 Assessing temporal coupling between two, or among three or more, neuroendocrine pulse trains: cross-correlation analysis, simulation methods, and conditional probability testing. Methods Neurosci 20:336-376
22. Keenan DM, Veldhuis JD 1997 Stochastic model of admixed basal and pulsatile hormone secretion as modulated by a deterministic oscillator. Am J Physiol 273:R1182-R1192
23. Veldhuis JD, Dufau ML 1989 Clinical pathophysiology of bioactive luteinizing hormone secretion in man. In: Gnessi L, ed. Unexplained infertility: basic and clinical aspects. New York: Raven Press; 237-263
24. Veldhuis JD, Urban RJ, Dufau ML 1994 Differential responses of biologically active LH secretion in older versus young men to interruption of androgen negative feedback. J Clin Endocrinol Metab 79:1763-1770
25. Winters SJ, Sherins RJ, Troen P 1984 The gonadotropin-suppressive activity of androgen is increased in elderly men. Metabolism 33:1052-1059
26. Winters SJ, Atkinson L 1997 Serum LH concentrations in hypogonadal men during transdermal testosterone replacement through scrotal skin: further evidence that aging enhances testosterone negative feedback. Clin Endocrinol (Oxf) 47:317-322
27. Gentili A, Mulligan T, Godschalk M, Clore J, Patrie J, Iranmanesh A, Veldhuis JD 2002 Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men. J Clin Endocrinol Metab 87:825-834
28. Deslypere JP, Kaufman JM, Vermeulen T, Vogelaers D, Vandalem JL, Vermeulen A 1987 Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J Clin Endocrinol Metab 64:68-73
29. Muta K, Kato K, Akamine Y, Ibayashi H 1981 Age-related changes in the feedback regulation of gonadotrophin secretion by sex steroids in men. Acta Endocrinol (Copenh) 96:154-162
30. Zwart A, Iranmanesh A, Veldhuis JD 1997 Disparate serum free testosterone concentrations and degrees of hypothalamo-pituitary-LH suppression are achieved by continuous versus pulsatile intravenous androgen replacement in men: a clinical experimental model of ketoconazole-induced reversible hypoandrogenemia with controlled testosterone add-back. J Clin Endocrinol Metab 82:2062-2069
31. Veldhuis JD, Zwart AD, Iranmanesh A 1997 Neuroendocrine mechanisms by which selective Leydig-cell castration unleashes increased pulsatile LH release in the human: an experimental paradigm of short-term ketoconazole-induced hypoandrogenemia and deconvolution-estimated LH secretory enhancement. Am J Physiol 272:R464-R474
32. Schnorr JA, Bray MJ, Veldhuis JD 2001 Aromatization mediates testosterone's short-term feedback restraint of 24-hour endogenously driven and acute exogenous GnRH-stimulated LH and FSH secretion in young men. J Clin Endocrinol Metab 86:2600-2606
33. Haji M, Kato KI, Nawata H, Ibayashi H 1980 Age-related changes in the concentrations of cytosol receptors for sex steroid hormones in the hypothalamus and pituitary gland of the rat. Brain Res 204:373-386
34. Roth GS 1979 Hormone receptor changes during adulthood and senescence: significance for aging research. Fed Proc 38:1910-1914
35. Keenan DM, Veldhuis JD 2004 Divergent gonadotropin-gonadal dose-responsive coupling in healthy young and aging men. Am J Physiol Regul Integr Comp Physiol 286:R381-R389
36. Nankin HR, Lin T, Murono EP 1981 The aging Leydig cell III. Gonadotropin stimulation in men. J Androl 2:181-186
37. Longcope C 1973 The effect of human chorionic gonadotropin on plasma steroid levels in young and old men. Steroids 21:583-592
38. Harman SM, Tsitouras PD 1980 Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin. J Clin Endocrinol Metab 51:35-40
39. Reubens R, Dhondt M, Vermeiden A 1976 Further studies on Leydig cell response to human choriogonadotropin. J Clin Endocrinol Metab 39:40-45
40. Brockwell PJ, Davis RA 1991 Time series: theory and methods. 2nd ed. New York: Springer-Verlag; 416
41. Press WH, Flannery BP, Teukolsky SA, Vetterling WT 1986 Numerical recipes, the art of scientific computing. Cambridge, UK: Cambridge Univeristy Press