Contrasts in the gonadotropin-releasing hormone dose-response relationships for luteinizing hormone, follicle-stimulating hormone and α-subunit release in young versus older men: Appraisal with high-specificity immunoradiometric assay and deconvolution analysis

European Journal of Endocrinology

Volumn 135, Issue 4, 1996, Pages 399-406

  Zwart, Alexander D ^c   Urban, Randall J ^d   Odell, William D ^b   Veldhuis, Johannes D ^a,e  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c Internal Medicine Endocrinology   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

^e UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADULT; AGED; AGING; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FOLLITROPIN RELEASE; HALF LIFE TIME; HUMAN; HYPOPHYSIS GONAD SYSTEM; IMMUNORADIOMETRIC ASSAY; LUTEINIZING HORMONE RELEASE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TESTOSTERONE BLOOD LEVEL;

EID: 0029856760     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1350399     Document Type: Article

References (28)

1. Vermeulen A. Clinical review 24 - androgens in the aging male. J Clin Endocrinol Metab 1991;73:221-4
2. Urban RJ, Veldhuis JD. Hypothalamo-pituitary concomitants of aging. In: Sowers JR, Felicetta JV, editors. The endocrinology of aging. New York: Raven Press, 1988:41-53
3. Blackman MR. Pituitary hormones and aging. Endocr Metab Clin 1987;16:981-90
4. Vermeulen A, Deslypere JP, De Meirleir K. A new look to the andropause: altered function of the gonadotrophs. J Steroid Biochem 1989;32:163-5
5. Snyder PJ, Reitano JF, Utiger RD, Serum LH and FSH responses to synthetic gonadotropin-releasing hormone in normal men. J Clin Endocrinol Metab 1975;41:938-45
6. Kaufman JM, Gin M, Deslypere JM, Thomas G, Vermeulen A. Influence of age on the responsiveness of the gonadotrophs to luteinizing hormone-releasing hormone in males. J Clin Endocrinol Metab 1991;72:1255-60
7. Harman SM, Tsitouras PD, Costa PT, Blackman MR. Reproductive hormones in aging men. II. Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone. J Clin Endocrinol Metab 1982;54:547-51
8. Coiro V, Passeri M, Volpi R, et al. Different effects of aging on the opioid mechanisms controlling gonadotropin and cortisol secretion in man. Horm Res 1989;32:119-23
9. Urban RJ, Veldhuis JD, Blizzard RM, Dufau ML. Attenuated release of biologically active luteinizing hormone in healthy aging men. J Clin Invest 1988;81:1020-9
10. Tenover JS, Matsumoto AM, Plymate SR, Bremner WJ. The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate. J Clin Endocrinol Metab 1987;65:1118-26
11. Ceda GP, Denti L, Ceresini G, Torsiglieri W, Hoffman AR, Valenti G. The effects of aging on the secretion of the common alpha-subunit of the glycoprotein hormones in men. J Am Geriatr Soc 1991;39:353-8
12. Veldhuis JD, Urban RJ, Lizarralde G, Johnson MJ, Iranmanesh A. Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging men. J Clin Endocrinol Metab 1992;75:52-8
13. Grover S, Griffin J, Odell WD. Ultrasensitive, specific, two-antibody immunoradiometric assay that detects free alpha subunits of glycoprotein hormones in blood of nonpregnant humans. Clin Chem 1991;37:2069-75
14. Veldhuis JD, Carlson ML, Johnson MJ. The pituitary gland secretes in bursts: Appraising the nature of glandular secretory impulses by simultaneous multiple parameter deconvolution of plasma hormone concentration. Proc Natl Acad Sci USA 1987;84: 7686-90
15. Wehmann RE, Nisula BC. Metabolic clearance rates of the subunits of human chorionic gonadotropin in man. J Clin Endocrinol Metab 1979;48:753-9
16. Veldhuis JD, Johnson ML. Deconvolution analysis of hormone data. Methods Enzymol 1992;210:539-75
17. Veldhuis JD, Johnson ML. Specific methodological approaches to selected contemporary issues in deconvolution analysis of pulsatile neuroendocrine data. Methods Neurosci 1995;28:25-92
18. Veldhuis JD, Winters SJ. Nature of alpha subunit secretion in men: circadian rhythms, pulsatile release and secretory profiles. J Androl 1989;10:248-58
19. Veldhuis JD, Fraioli F, Rogol AD, Dufau ML. Metabolic clearance rate of biologically active luteinizing hormone in man. J Clin Invest 1986;77:1122-8
20. Veldhuis JD, Lassiter AE, Johnson ML. Operating behavior of dual or multiple endocrine pulse generators. Am J Physiol 1990;259 (Endocrinol Metab 22):E351-61
21. Pontiroli AE, Ruga S, Maffi P, Scaglia L, Perfetti MG, Pozza G. Pituitary reserve after repeated administrations of releasing hormones in young and elderly men: reproducibility on different days. J Endocrinol Invest 1992;15:559-66
22. Vermeulen A, Kaufman JM, Editorial: role of the hypothalamo-pituitary function in the hypoandrogenism of healthy aging. J Clin Endocrinol Metab 1992;75:704-6
23. Marshall JC, Anderson DC, Russell Fraser T, Harsoulis P. Human luteinizing hormone in man: studies of metabolism and biological action. J Endocrinol 1993;56:431-9
24. Urban RJ, Padmanabhan V, Beitins I, Veldhuis JD. Metabolic clearance of human follicle-stimulating hormone assessed by radioimmunoassay, immunoradiometric assay, and in vitro Sertoli cell bioassay. J Clin Endocrinol Metab 1991;73:818-23
25. Vermeulen A, Deslypere JP, Kaufman JJ. Influence of antiopioids on luteinizing hormone pulsatility in aging men. J Clin Endocrinol Metab 1989;68:68-72
26. Monroe SE, Levine L, Chang RJ, Keye Jr WR, Yamamoto M, Jaffe RB. Prolactin-secreting pituitary adenomas. V. Increased gonadotroph responsivity in hyperprolactinemic women with pituitary adenomas. J Clin Endocrinol Metab 1981;52:1171-8
27. Veldhuis JD, Evans WS, Demers LM, Thorner MO, Wakat D, Rogol AD. Altered neuroendocrine regulation of gonadotropin secretion in women distance runners. J Clin Endocrinol Metab 1985;61: 557-63
28. Veldhuis JD, Iranmanesh A, Evans WS, Lizarralde G, Thorner MO, Vance ML. Amplitude suppression of the pulsatile mode of immunoradiometric LH release in fasting-induced hypoandrogenemia in normal men. J Clin Endocrinol Metab 1993;76: 587-93