Structure-function studies of linear and cyclized peptide antagonists of the GnRH receptor

Biochemical and Biophysical Research Communications

Volumn 289, Issue 3, 2001, Pages 653-663

  Beckers, Thomas ^a   Bernd, Michael ^a   Kutscher, Bernd ^a   Kühne, Ronald ^b   Hoffmann, Silke ^a   Reissmann, Thomas ^a  

^a ASTA MEDICA AG   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

GnRH receptor; Peptide antagonists; Pharmacodynamic properties; Receptor ligand interactions; Testosterone suppression

Indexed keywords

ASPARAGINE; CETRORELIX; CYCLOANTARELIX; CYCLOPEPTIDE; CYCLORELIX; D 20455; D 21074; D 23234; D 23487; D 23561; D 23620; D 23938; D 23998; D 24236; D 24351; D 24418; D 24598; D 49141; D 49650; D 49651; D 52391; D 63153; GANIRELIX; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; ITURELIX; MUTANT PROTEIN; PENTAPEPTIDE; PEPTIDE; SEMITWICERELIX; TESTOSTERONE; TEVERELIX; TRYPTOPHAN; TWICERELIX; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CYCLIZATION; DRUG BIOAVAILABILITY; DRUG RECEPTOR BINDING; HORMONE DEFICIENCY; HUMAN; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0035824464     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5939     Document Type: Article

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