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Volumn 141, Issue 3, 1999, Pages 257-266

Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig cell) defects in the healthy aging male gonadotropic axis

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; LUTEINIZING HORMONE; TESTOSTERONE;

EID: 0032879225     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1410257     Document Type: Article
Times cited : (115)

References (45)
  • 1
    • 0023954666 scopus 로고
    • Contemporary aspects of discrete peak-detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men
    • Urban RJ, Evans WS, Rogol AD, Kaiser DL, Johnson ML & Veldhuis JD. Contemporary aspects of discrete peak-detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men. Endocrine Reviews 1988 9 3-37.
    • (1988) Endocrine Reviews , vol.9 , pp. 3-37
    • Urban, R.J.1    Evans, W.S.2    Rogol, A.D.3    Kaiser, D.L.4    Johnson, M.L.5    Veldhuis, J.D.6
  • 2
    • 0000572499 scopus 로고
    • Dynamics of the male hypothalamo-pituitary-gonadal axis
    • Eds SC Yen & RB Jaffe. Philadelphia: WB Saunders
    • Veldhuis JD. Dynamics of the male hypothalamo-pituitary-gonadal axis. In Reproductive Endocrinology, pp 409-459. Eds SC Yen & RB Jaffe. Philadelphia: WB Saunders, 1991.
    • (1991) Reproductive Endocrinology , pp. 409-459
    • Veldhuis, J.D.1
  • 3
    • 0031876840 scopus 로고    scopus 로고
    • A biomathematical model of time-delayed feedback in the human male hypothalamic-pituitary-Leydig cell axis
    • Keenan DM & Veldhuis JD. A biomathematical model of time-delayed feedback in the human male hypothalamic-pituitary-Leydig cell axis. American Journal of Physiology 1998 275 E157-E176.
    • (1998) American Journal of Physiology , vol.275
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 5
    • 0024509604 scopus 로고
    • Importance of gonadal steroids to bone mass in men with hyperprolactinemic hypogonadism
    • Greenspan SL, Oppenheim DS & Klibanski A. Importance of gonadal steroids to bone mass in men with hyperprolactinemic hypogonadism. Annals of Internal Medicine 1989 110 526-531.
    • (1989) Annals of Internal Medicine , vol.110 , pp. 526-531
    • Greenspan, S.L.1    Oppenheim, D.S.2    Klibanski, A.3
  • 8
    • 10244222400 scopus 로고    scopus 로고
    • Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption and increases bone formation markers in hypogonadal men
    • Wang C, Eyre DR, Clark R, Kleinberg D, Newman C, Iranmanesh A et al. Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption and increases bone formation markers in hypogonadal men. Journal of Clinical Endocrinology and Metabolism 1996 81 3654-3662.
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , pp. 3654-3662
    • Wang, C.1    Eyre, D.R.2    Clark, R.3    Kleinberg, D.4    Newman, C.5    Iranmanesh, A.6
  • 15
    • 0021060805 scopus 로고
    • Endogenous opiates modulate the pulsatile secretion of biologically active luteinizing hormone in man
    • Veldhuis JD, Rogol AD, Johnson ML & Dufau ML. Endogenous opiates modulate the pulsatile secretion of biologically active luteinizing hormone in man. Journal of Clinical Investigation 1983 72 2031-2040.
    • (1983) Journal of Clinical Investigation , vol.72 , pp. 2031-2040
    • Veldhuis, J.D.1    Rogol, A.D.2    Johnson, M.L.3    Dufau, M.L.4
  • 17
    • 0022447036 scopus 로고
    • Cluster analysis: A simple, versatile and robust algorithm for endocrine pulse detection
    • Veldhuis JD & Johnson ML. Cluster analysis: a simple, versatile and robust algorithm for endocrine pulse detection. American Journal of Physiology 1986 250 E486-E493.
    • (1986) American Journal of Physiology , vol.250
    • Veldhuis, J.D.1    Johnson, M.L.2
  • 20
    • 0029856760 scopus 로고    scopus 로고
    • Contrasts in the gonadotropin-releasing dose-response relationships for luteinizing hormone, follicle-stimulating hormone, and alpha-subunit release in young vs older men: Appraisal with high-specificity immunoradiometric assay and deconvolution analysis
    • Zwart AD, Urban RJ, Odell WD & Veldhuis JD. Contrasts in the gonadotropin-releasing dose-response relationships for luteinizing hormone, follicle-stimulating hormone, and alpha-subunit release in young vs older men: appraisal with high-specificity immunoradiometric assay and deconvolution analysis. European Journal of Endocrinology 1996 135 399-406.
    • (1996) European Journal of Endocrinology , vol.135 , pp. 399-406
    • Zwart, A.D.1    Urban, R.J.2    Odell, W.D.3    Veldhuis, J.D.4
  • 22
    • 0020458001 scopus 로고
    • Reproductive hormones in aging men. II. Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone
    • Harman SM, Tsitouras PD, Costa PT & Blackman MR. Reproductive hormones in aging men. II. Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone. Journal of Clinical Endocrinology and Metabolism 1982 54 547-551.
    • (1982) Journal of Clinical Endocrinology and Metabolism , vol.54 , pp. 547-551
    • Harman, S.M.1    Tsitouras, P.D.2    Costa, P.T.3    Blackman, M.R.4
  • 23
    • 0021745070 scopus 로고
    • Effects of acute stimulation with gonadotropin-releasing hormone (GnRH) on biologically active serum luteinizing hormone (LH) in elderly men
    • Celani MF, Montanini V, Baraghini GF, Carani C & Marrama P. Effects of acute stimulation with gonadotropin-releasing hormone (GnRH) on biologically active serum luteinizing hormone (LH) in elderly men. Journal of Endocrinological Investigation 1984 7 589-594.
    • (1984) Journal of Endocrinological Investigation , vol.7 , pp. 589-594
    • Celani, M.F.1    Montanini, V.2    Baraghini, G.F.3    Carani, C.4    Marrama, P.5
  • 24
    • 0028787967 scopus 로고
    • Amplified nocturnal luteinizing hormone (LH) secretory bursts frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in healthy aged men: Possible Leydig cell desensitization to endogenous LH signaling - A clinical research center study
    • Mulligan T, Iranmanesh A, Gheorghiu S, Godschalk M & Veldhuis JD. Amplified nocturnal luteinizing hormone (LH) secretory bursts frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in healthy aged men: possible Leydig cell desensitization to endogenous LH signaling - a clinical research center study. Journal of Clinical Endocrinology and Metabolism 1995 80 3025-3031.
    • (1995) Journal of Clinical Endocrinology and Metabolism , vol.80 , pp. 3025-3031
    • Mulligan, T.1    Iranmanesh, A.2    Gheorghiu, S.3    Godschalk, M.4    Veldhuis, J.D.5
  • 26
    • 0020385669 scopus 로고
    • Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: Evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion
    • Winters SJ & Troen P. Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion. Journal of Clinical Endocrinology and Metabolism 1982 55 560-565.
    • (1982) Journal of Clinical Endocrinology and Metabolism , vol.55 , pp. 560-565
    • Winters, S.J.1    Troen, P.2
  • 27
    • 0027196203 scopus 로고
    • Age-related deficits in brain estrogen receptors and sexual behavior of male rats
    • Rosselli CE, Thornton JE & Chambers KC. Age-related deficits in brain estrogen receptors and sexual behavior of male rats. Behavioral Neuroscience 1993 107 202-209.
    • (1993) Behavioral Neuroscience , vol.107 , pp. 202-209
    • Rosselli, C.E.1    Thornton, J.E.2    Chambers, K.C.3
  • 28
    • 0028047259 scopus 로고
    • Ultrastructural changes in gonadotropin-releasing hormone neurons as a function of age and ovariectomy in rats
    • Romero MT, Silverman AJ, Wise PM & Witkin JW. Ultrastructural changes in gonadotropin-releasing hormone neurons as a function of age and ovariectomy in rats. Neuroscience 1994 58 217-225.
    • (1994) Neuroscience , vol.58 , pp. 217-225
    • Romero, M.T.1    Silverman, A.J.2    Wise, P.M.3    Witkin, J.W.4
  • 30
    • 0023407270 scopus 로고
    • Restoration of sexual function and fertility by fetal hypothalamic transplant in impotent aged male rats
    • Huang HH, Kissane JQ & Haawrylewicz EJ. Restoration of sexual function and fertility by fetal hypothalamic transplant in impotent aged male rats. Neurobiology of Aging 1987 8 465-472.
    • (1987) Neurobiology of Aging , vol.8 , pp. 465-472
    • Huang, H.H.1    Kissane, J.Q.2    Haawrylewicz, E.J.3
  • 31
    • 0030592747 scopus 로고    scopus 로고
    • Effects of aging on N-methyl-D-aspartate (NMDA)-induced GnRH and LH release in female rats
    • Arias P, Carbone S, Szwarcfarb B, Feleder C, Rodriguez M, Scacchi P et al. Effects of aging on N-methyl-D-aspartate (NMDA)-induced GnRH and LH release in female rats. Brain Research 1996 740 234-238.
    • (1996) Brain Research , vol.740 , pp. 234-238
    • Arias, P.1    Carbone, S.2    Szwarcfarb, B.3    Feleder, C.4    Rodriguez, M.5    Scacchi, P.6
  • 32
    • 0027275205 scopus 로고
    • Age-related decline in the steroidogenic capacity of isolated rat Leydig cells: A defect in cholesterol mobilization and processing
    • Liao C, Reaven E & Azhar S. Age-related decline in the steroidogenic capacity of isolated rat Leydig cells: a defect in cholesterol mobilization and processing. Journal of Steroid Biochemistry and Molecular Biology 1993 46 39-47.
    • (1993) Journal of Steroid Biochemistry and Molecular Biology , vol.46 , pp. 39-47
    • Liao, C.1    Reaven, E.2    Azhar, S.3
  • 33
    • 0021231719 scopus 로고
    • Leydig cell function in normal men: Effect of age, lifestyle, residence, diet and activity
    • Deslypere JP & Vermeulen A. Leydig cell function in normal men: effect of age, lifestyle, residence, diet and activity. Journal of Clinical Endocrinology and Metabolism 1984 59 955-962.
    • (1984) Journal of Clinical Endocrinology and Metabolism , vol.59 , pp. 955-962
    • Deslypere, J.P.1    Vermeulen, A.2
  • 34
    • 0028948069 scopus 로고
    • Age-related changes in the pituitary-testicular axis in normal men; lower serum testosterone results from decreased bioactive LH drive
    • Mitchell R, Hollis S, Rothwell C & Robertson WR. Age-related changes in the pituitary-testicular axis in normal men; lower serum testosterone results from decreased bioactive LH drive. Clinical Endocrinology 1995 42 501-507.
    • (1995) Clinical Endocrinology , vol.42 , pp. 501-507
    • Mitchell, R.1    Hollis, S.2    Rothwell, C.3    Robertson, W.R.4
  • 35
    • 0021271256 scopus 로고
    • Decrease in luteinizing hormone biological activity/immunoreactivity ratio in elderly men
    • Marrama P, Montanini V, Celani MF, Carani C, Cioni K, Bazzani M et al. Decrease in luteinizing hormone biological activity/immunoreactivity ratio in elderly men. Maturitas 1984 5 223-231.
    • (1984) Maturitas , vol.5 , pp. 223-231
    • Marrama, P.1    Montanini, V.2    Celani, M.F.3    Carani, C.4    Cioni, K.5    Bazzani, M.6
  • 38
    • 0027515357 scopus 로고
    • Serum glycoprotein hormones and their free alpha-subunit in a healthy elderly population selected according to the SENIEUR protocol. Analyses with ultrasensitive time resolved fluoroimmunoassays
    • Madersbacher S, Stulnig T, Huber LA, Schonitzer D, Dirnhofer S, Wick G et al. Serum glycoprotein hormones and their free alpha-subunit in a healthy elderly population selected according to the SENIEUR protocol. Analyses with ultrasensitive time resolved fluoroimmunoassays. Mechanisms of Aging and Development 1993 71 223-233.
    • (1993) Mechanisms of Aging and Development , vol.71 , pp. 223-233
    • Madersbacher, S.1    Stulnig, T.2    Huber, L.A.3    Schonitzer, D.4    Dirnhofer, S.5    Wick, G.6
  • 39
    • 0028557257 scopus 로고
    • Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback
    • Veldhuis JD, Urban RJ & Dufau ML. Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback. Journal of Clinical Endocrinology and Metabolism 1994 79 1763-1770.
    • (1994) Journal of Clinical Endocrinology and Metabolism , vol.79 , pp. 1763-1770
    • Veldhuis, J.D.1    Urban, R.J.2    Dufau, M.L.3
  • 41
    • 0028194849 scopus 로고
    • The Brown Norway rat as a model for male reproductive aging: Evidence for both primary and secondary testicular failure
    • Gruenewald DA, Naai MA, Hess DL & Matsumoto AM. The Brown Norway rat as a model for male reproductive aging: evidence for both primary and secondary testicular failure. Journal of Gerontology 1994 49 B42-B50.
    • (1994) Journal of Gerontology , vol.49
    • Gruenewald, D.A.1    Naai, M.A.2    Hess, D.L.3    Matsumoto, A.M.4
  • 42
    • 0031736458 scopus 로고    scopus 로고
    • Does age-associated reduced Leydig cell testosterone production in Brown Norway rats result from understimulation by luteinizing hormone?
    • Grzywacz FW, Chen H, Allegretti J & Zirkin BR. Does age-associated reduced Leydig cell testosterone production in Brown Norway rats result from understimulation by luteinizing hormone? Journal of Andrology 1998 19 625-630.
    • (1998) Journal of Andrology , vol.19 , pp. 625-630
    • Grzywacz, F.W.1    Chen, H.2    Allegretti, J.3    Zirkin, B.R.4
  • 44
    • 0028327778 scopus 로고
    • Sertoli cell function declines earlier than Leydig cell function in aging Japanese men
    • Haji M, Tanaka S, Nishi Y, Yanase T, Takayanagi R, Hasegawa Y et al. Sertoli cell function declines earlier than Leydig cell function in aging Japanese men. Maturitas 1994 18 143-153.
    • (1994) Maturitas , vol.18 , pp. 143-153
    • Haji, M.1    Tanaka, S.2    Nishi, Y.3    Yanase, T.4    Takayanagi, R.5    Hasegawa, Y.6


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