Structural and Functional Studies of the Biotin Protein Ligase from Aquifex aeolicus Reveal a Critical Role for a Conserved Residue in Target Specificity

Journal of Molecular Biology

Volumn 387, Issue 1, 2009, Pages 129-146

  Tron, Cecile M ^a   McNae, Iain W ^b   Nutley, Margaret ^c   Clarke, David J ^a   Cooper, Alan ^c   Walkinshaw, Malcolm D ^b   Baxter, Robert L ^a   Campopiano, Dominic J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

biotin protein ligase; biotinylation; isothermal titration calorimetry; post translation modification; X ray crystallography

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARGININE; BIOTIN; CARBOXYL GROUP; MAGNESIUM; PHOSPHATE;

AQUIFEX AEOLICUS; ARTICLE; BIOTINYLATION; CATALYSIS; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; GENE MUTATION; HYPERTHERMOPHILIC ARCHAEON; ISOTHERMAL TITRATION CALORIMETRY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; TARGET ORGANISM; THERMODYNAMICS; WESTERN BLOTTING; WILD TYPE;

AQUIFEX AEOLICUS;

EID: 61449218735     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.12.086     Document Type: Article

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