Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived aspergillus sp.

Journal of the American Chemical Society

Volumn 132, Issue 36, 2010, Pages 12733-12740

  Ding, Yousong ^a   Wet, Jeffrey R De ^a   Cavalcoli, James ^a   Li, Shengying ^a   Greshock, Thomas J ^b,c   Miller, Kenneth A ^b,c   Finefield, Jennifer M ^b,c   Sunderhaus, James D ^b,c   McAfoos, Timothy J ^b,c   Tsukamoto, Sachiko ^d   Williams, Robert M ^b,c   Sherman, David H ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^d KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CANCER AGENTS; ASPERGILLUS SP; BELONG TO; BIOSYNTHETIC GENE CLUSTER; INDOLE ALKALOIDS; NATURAL PRODUCTS; PRENYLATION; RING SYSTEMS; SECONDARY METABOLITES; STRUCTURAL DIVERSITY; WHOLE GENOME SEQUENCING;

BIOCHEMISTRY; FUNGI; GENES; METABOLISM; METABOLITES;

BIOSYNTHESIS;

ANTINEOPLASTIC AGENT; BICYCLO[2.2.2]OCTANE DERIVATIVE; DIMETHYLALLYLTRANSFERASE; INDOLE ALKALOID; NATURAL PRODUCT; NOTOAMIDE; STEPHACIDIN; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; GENE CLUSTER; GENE SEQUENCE; MARINE SPECIES; NONHUMAN; NUCLEOTIDE SEQUENCE; PRENYLATION; REACTION ANALYSIS; STEREOCHEMISTRY;

ANIMALS; ANTINEOPLASTIC AGENTS; ASPERGILLUS; BIOLOGICAL FACTORS; GENOME; INDOLE ALKALOIDS; MOLECULAR CONFORMATION; PRENYLATION; STEREOISOMERISM;

EID: 77956422779     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1049302     Document Type: Article

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