Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation

Molecular Genetics and Metabolism

Volumn 104, Issue 4, 2011, Pages 608-619

  Baldo, Guilherme ^a   Wu, Susan ^a   Howe, Ruth A ^a   Ramamoothy, Meera ^a   Knutsen, Russell H ^a   Fang, Jiali ^a   Mecham, Robert P ^a   Liu, Yuli ^a   Wu, Xiaobo ^a   Atkinson, John P ^a   Ponder, Katherine P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aortic dilatation; Cathepsin S; Complement system; Gene therapy; Matrix metalloproteinase 12; Mucopolysaccharidosis VII

Indexed keywords

BETA GLUCURONIDASE; CATHEPSIN S; COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR D; ELASTIN; MACROPHAGE ELASTASE; MESSENGER RNA; RETROVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA DILATATION; AORTA DISEASE; AORTA MEDIA; ARTICLE; BIOACCUMULATION; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CONTROLLED STUDY; ENZYME DEFICIENCY; GENOTYPE; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; MOUSE; MUCOPOLYSACCHARIDOSIS TYPE 7; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; AORTA; AORTIC DISEASES; CATHEPSINS; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM PROTEINS; DILATATION, PATHOLOGIC; ELASTIN; GENE EXPRESSION PROFILING; GENE THERAPY; GLUCURONIDASE; GLYCOSAMINOGLYCANS; MALE; MATRIX METALLOPROTEINASE 12; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUCOPOLYSACCHARIDOSIS VII; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC ELASTASE; SIGNAL TRANSDUCTION; TISSUE EXTRACTS; UP-REGULATION;

MUS;

EID: 82255175888     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2011.08.018     Document Type: Article

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