Congenital cataract causing mutants of αA-crystallin/sHSP form aggregates and aggresomes degraded through ubiquitin-proteasome pathway

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Raju, Ilangovan ^a   Abraham, Edathara C ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; BIOLOGICAL MARKER; CYCLOHEXIMIDE; GAMMA TUBULIN; PROTEASOME; UBIQUITIN;

AGGRESOME; ARTICLE; CENTROSOME; CONFOCAL LASER MICROSCOPY; CONGENITAL CATARACT; CONTROLLED STUDY; DOWN REGULATION; HELA CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MOLECULAR CLONING; MOLECULAR PATHOLOGY; MUTANT; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SITE DIRECTED MUTAGENESIS; UPREGULATION; WESTERN BLOTTING; WILD TYPE;

ALPHA-CRYSTALLIN A CHAIN; BLOTTING, WESTERN; CATARACT; HEAT-SHOCK PROTEINS; HELA CELLS; HUMANS; INCLUSION BODIES; MUTANT PROTEINS; MUTATION; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, QUATERNARY; PROTEOLYSIS; RECOMBINANT FUSION PROTEINS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITINATION;

EID: 82255173875     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028085     Document Type: Article

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