Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status

Journal of Translational Medicine

Volumn 9, Issue 1, 2011, Pages

  Lo, Bernice ^a   Swafford, Austin D E ^a,b   Shafer Weaver, Kimberly A ^a   Jerome, Lawrence F ^c   Rakhlin, Luba ^a   Mathern, Douglas R ^a   Callahan, Conor A ^a   Jiang, Ping ^a   Davison, Lucy J ^b   Stevens, Helen E ^b   Lucas, Carrie L ^a   White, Jill ^c   von Borstel, Reid ^d   Todd, John A ^b   Lenardo, Michael J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Wellstat Diagnostics   (United States)

^d Wellstat Therapeutics Corporation   (United States)

Author keywords

Diabetes; ECL; Electrochemiluminescence; Human autoantibodies; IA; IAA; Insulin; NOD mice

Indexed keywords

AUTOANTIBODY; GLUCOSE; INSULIN ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; BINDING ASSAY; CHEMOLUMINESCENCE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE SEVERITY; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; IMMUNOASSAY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; INTERMETHOD COMPARISON; ISOTOPE LABELING; LABORATORY TEST; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; ANIMAL; BLOOD; DISEASE COURSE; ELECTROCHEMISTRY; LUMINESCENCE; METABOLISM; METHODOLOGY; PANCREAS ISLET BETA CELL; PATHOLOGY; RADIOASSAY; RECEIVER OPERATING CHARACTERISTIC;

ANIMALS; AUTOANTIBODIES; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; ELECTROCHEMISTRY; FEMALE; HUMANS; INSULIN ANTIBODIES; INSULIN-SECRETING CELLS; LUMINESCENT MEASUREMENTS; MICE; MICE, INBRED NOD; RADIOLIGAND ASSAY; REPRODUCIBILITY OF RESULTS; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 82155187075     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-203     Document Type: Article

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