The role of cytokines and chemokines in Histoplasma capsulatum infection

Cytokine

Volumn 58, Issue 1, 2012, Pages 112-117

  Kroetz, Danielle N ^a   Deepe, George S ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Chemokine; Cytokine; Fungus; Infection

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 35; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 3; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; ZINC;

APOPTOSIS; ASPERGILLUS FUMIGATUS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; FUNGUS IMMUNITY; HISTOPLASMA CAPSULATUM; HISTOPLASMOSIS; HUMAN; INFECTION SENSITIVITY; INFLAMMATION; INTERFERON PRODUCTION; LUNG MYCOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVIEW; TH1 CELL; TH17 CELL;

ANIMALS; CHEMOKINES; CYTOKINES; HISTOPLASMA; HISTOPLASMOSIS; HUMANS; MICE; RECEPTORS, CCR5; TH1 CELLS; TH17 CELLS;

AJELLOMYCES CAPSULATUS; FUNGI;

EID: 82155182592     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.07.430     Document Type: Review

References (65)

1. Woods J.P. Knocking on the right door and making a comfortable home: Histoplasma capsulatum intracellular pathogenesis. Curr Opin Microbiol 2003, 6:327-331.
2. Deepe G.S., Bullock W.E. Histoplasmosis: a granulomatous inflammatory response. Basic Principles and Clinical Correlates 1988, 733-749. Raven Press Ltd., New York, [Chapter 40]. J.J. Gallin, I.M. Goldstein, R. Snyder (Eds.).
3. Kauffman C.A. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev 2007, 20:115-132.
4. Gildea L.A., Morris R.E., Newman S.L. Histoplasma capsulatum yeasts are phagocytosed via very late antigen-5, killed, and processed for antigen presentation by human dendritic cells. J Immunol 2001, 166:1049-1056.
5. Brummer E., Kurita N., Yosihida S., Nishimura K., Miyaji M. Fungistatic activity of human neutrophils against Histoplasma capsulatum: correlation with phagocytosis. J Infect Dis 1991, 164:158-162.
6. Kurita N., Brummer E., Yoshida S., Nishimura K., Miyaji M. Antifungal activity of murine polymorphonuclear neutrophils against Histoplasma capsulatum. J Med Vet Mycol 1991, 29:133-143.
7. Newman S.L., Gootee L., Gabay J.E. Human neutrophil-mediated fungistasis against Histoplasma capsulatum. Localization of fungistatic activity to the azurophil granules. J Clin Invest 1993, 92:624-631.
8. Strasser J.E., Newman S.L., Ciraolo G.M., Morris R.E., Howell M.L., Dean G.E. Regulation of the macrophage vacuolar ATPase and phagosome-lysosome fusion by Histoplasma capsulatum. J Immunol 1999, 162:6148-6154.
9. Marth T., Kelsall B.L. Regulation of interleukin-12 by complement receptor 3 signaling. J Exp Med 1997, 185:1987-1995.
10. Zhou P., Sieve M.C., Bennett J., Kwon-Chung K.J., Tewari R.P., Gazzinelli R.T., et al. IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ. J Immunol 1995, 155:785-795.
11. Cain J.A., Deepe G.S. Evolution of the primary immune response to Histoplasma capsulatum in murine lung. Infect Immun 1998, 66:1473-1481.
12. Allendorfer R., Brunner G.D., Deepe G.S. Complex requirements for nascent and memory immunity in pulmonary histoplasmosis. J Immunol 1999, 162:7389-7396.
13. Lane T.E., Otero G.C., Wu-Hsieh B.A., Howard D.H. Expression of inducible nitric oxide synthase by stimulated macrophages correlates with their antihistoplasma activity. Infect Immun 1994, 62:1478-1479.
14. Nakamura L.T., Wu-Hsieh B.A., Howard D.H. Recombinant murine gamma interferon stimulates macrophages of the RAW cell line to inhibit intracellular growth of Histoplasma capsulatum. Infect Immun 1994, 62:680-684.
15. Lane T.E., Wu-Hsieh B.A., Howard D.H. Iron limitation and the gamma interferon-mediated antihistoplasma state of murine macrophages. Infect Immun 1991, 59:2274-2278.
16. Winters M.S., Chan Q., Caruso J.A., Deepe G.S. Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses. J Infect Dis 2010, 202:1136-1145.
17. Byrd T.F., Horwitz M.A. Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. J Clin Invest 1989, 83:1457-1465.
18. Nairz M., Fritsche G., Brunner P., Talasz H., Hantke K., Weiss G. Interferon-gamma limits the availability of iron for intramacrophage Salmonella typhimurium. Eur J Immunol 2008, 38:1923-1936.
19. Allendoerfer R., Deepe G.S. Blockade of endogenous TNF-alpha exacerbates primary and secondary pulmonary histoplasmosis by differential mechanisms. J Immunol 1998, 160:6072-6082.
20. Deepe G.S., Gibbons R.S. T cells require tumor necrosis factor-α to provide protective immunity in mice infected with Histoplasma capsulatum. J Infect Dis 2006, 193:322-330.
21. Smith J.G., Magee D.M., Williams D.M., Graybill J.R. Tumor necrosis factor-alpha plays a role in host defense against Histoplasma capsulatum. J Infect Dis 1990, 162:1349-1353.
22. Wood K.L., Hage C.A., Knox K.S., Kleiman M.B., Sannuti A., Day R.B., et al. Histoplasmosis after treatment with anti-tumor necrosis factor-alpha therapy. Am J Respir Crit Care Med 2003, 167:1279-1282.
23. Szymczak W.A., Deepe G.S. The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity. J Immunol 2009, 183:1964-1974.
24. + T cells in fungal infection. J Immunol 2010, 184:5224-5231.
25. Allen H.L., Deepe G.S. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. J Clin Invest 2005, 115:2875-2885.
26. + T cells that inhibit protective immunity in murine histoplasmosis. J Immunol 2008, 180:1088-1097.
27. Malek T.R., Yu A., Vincek V., Scibelli P., Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002, 17:167-178.
28. Deepe G.S., Gibbons R., Woodward E. Neutralization of endogenous granulocyte-macrophage colony-stimulating factor subverts the protective immune response to Histoplasma capsulatum. J Immunol 1999, 163:4985-4993.
29. Deepe G.S., McGuinness M. Interleukin-1 and host control of pulmonary histoplasmosis. J Infect Dis 2006, 194:855-864.
30. Sutton C., Brereton C., Keogh B., Mills K.H., Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006, 203:1685-1691.
31. Newman S.L., Gootee L. Colony-stimulating factors activate human macrophages to inhibit intracellular growth of Histoplasma capsulatum yeasts. Infect Immun 1992, 60:4593-4597.
32. Deepe G.S., Gibbons R.S. Interleukins 17 and 23 influence the host response to Histoplasma capsulatum. J Infect Dis 2009, 200:142-151.
33. + T helper cells. Cell 2006, 126:1121-1133.
34. Zhou L., Ivanov R., Spolski R., Min K., Shenderov T., Egawa D.E., et al. IL-6 programs Th-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007, 8:967-974.
35. Kleinschek M.A., Muller U., Brodie S.J., Stenzel W., Kohler G., Blumenschein W.M., et al. IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J. Immunol. 2006, 176:1098-1106.
36. Huang W., Na L., Fidel P.L., Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 2004, 190:624-631.
37. Zelante T., De Luca A., Bonifazi P., Montagnoli C., Bozza S., Moretti S., et al. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol 2007, 37:2695-2706.
38. Heninger E., Hogan L.H., Karman J., Macvilay S., Hill B., Woods J.P., et al. Characterization of the Histoplasma capsulatum-induced granuloma. J Immunol 2006, 177:3303-3313.
39. Korn T., Bettelli E., Gao W., Awasthi A., Jager A., Strom T.B., et al. IL-21 initiates an alternative pathway to induce proinflammatory Th17 cells. Nature 2007, 448:484-487.
40. Wuthrich M., Gern B., Hung C.Y., Ersland K., Rocco N., Pick-Jacobs J., et al. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest 2011, 121:554-568.
41. Peng J.K., Lin J.S., Kung J.T., Finkelman F.D., Wu-Hsieh B.A. The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection. Int Immunol 2005, 17:193-205.
42. Deepe G.S., Gibbons R.S. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. J Immunol 2003, 171:5353-5362.
43. Gildea L.A., Gibbons R., Finkelman F.D., Deepe G.S. Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatum. Infect Immun 2003, 71:3787-3793.
44. Rutschman R., Lang R., Hesse M., Ihle J.N., Wynn T.A., Murray P.J. Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production. J Immunol 2001, 166:2173-2177.
45. Sharma P., Chakraborty R., Wang L., Min B., Tremblay M.L., Kawahara T., et al. Redox regulation of interleukin-4 signaling. Immunity 2008, 29:551-564.
46. Kahnert A., Seiler P., Stein M., Bandermann S., Hahnke K., Mollenkopf H., et al. Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis. Eur J Immunol 2006, 36:631-647.
47. Inglis D.O., Berkes C.A., Hocking Murray D.R., Sil A. Conidia but not yeast cells of the fungal pathogen Histoplasma capsulatum trigger a type I interferon innate immune response in murine macrophages. Infect Immun 2010, 78:3871-3882.
48. Loyd J.E., Tillman B.F., Atkinson J.B., Des Prez R.M. Mediastinal fibrosis complicating histoplasmosis. Medicine (Baltimore) 1988, 67:295-310.
49. Zlotnik A., Yoshie O., Nomiyama H. The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol 2006, 7:243.
50. Zlotnik A., Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000, 12:121-127.
51. Tanaka Y., Adams D.H., Hubscher S., Hirano H., Siebenlist U., Shaw S. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1 beta. Nature 1993, 361:79-82.
52. Luther S.A., Cyster J.G. Chemokines as regulators of T cell differentiation. Nat Immunol 2001, 2:102-107.
53. Wong M.M., Fish E.N. Chemokines: attractive mediators of the immune response. Semin Immunol 2003, 15:5-14.
54. Wang J., Guan E., Roderiquez G., Norcross M.A. Inhibition of CCR5 expression by IL-12 through induction of β-chemokines in human T lymphocytes. J Immunol 1999, 163:5763-5769.
55. Medeiros A.I., Malheiro A., Jose P.J., Conroy D.M., Williams T.J., Faccioli L.H. Differential release of MIP-1α and eotaxin during infection of mice by Histoplasma capsulatum or inoculation of beta-glucan. Inflamm Res 2004, 53:351-354.
56. Moreira A.P., Cavassani K.A., Massafera Tristao F.S., Campanelli A.P., Martinez R., Rossi M.A., et al. CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression. J Immunol 2008, 180:3049-3056.
57. + regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med 2006, 203:2451-2460.
58. Bystry R.S., Aluvihare V., Welch K.A., Kallikourdis M., Betz A.G. B cells and professional APCs recruit regulatory T cells via CCL4. Nat Immunol 2001, 2:1126-1132.
59. -/- mice is coupled with an enhanced adaptive immune response in fungal infection. J. Immunol. 2011, 186:5949-5955.
60. H17 and regulatory T cells. Nature 2006, 441:235-238.
61. Stritesky G.L., Yeh N., Kaplan M.H. IL-23 promotes maintenance but not commitment to the Th17 lineage. J Immunol 2008, 181:5948-5955.
62. Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002, 16:779-790.
63. Devergne O., Birkenbach M., Kieff E. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc Natl Acad Sci USA 1997, 94:12041-12046.
64. Stumhofer J.S., Laurence A., Wilson E.H., Huang E., Tato C.M., Johnson L.M., et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 2006, 7:937-945.
65. Niedbala W., Wei X.Q., Cai B., Hueber A.J., Leung B.P., McInnes I.B., et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol 2007, 37:3021-3029.