Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Alvino, Clair L ^a   Ong, Shee Chee ^a   McNeil, Kerrie A ^a   Delaine, Carlie ^a   Booker, Grant W ^a   Wallace, John C ^a   Forbes, Briony E ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR KINASE; PROTEIN KINASE B; SOMATOMEDIN B; SOMATOMEDIN RECEPTOR; DRUG DERIVATIVE; MUTANT PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HORMONE ACTION; IC 50; LIGAND BINDING; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN FUNCTION; PROTEIN INTERACTION; RESIDUE ANALYSIS; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BINDING COMPETITION; BIOSYNTHESIS; CHEMISTRY; ENZYME ASSAY; METABOLISM; MOLECULAR GENETICS; MOUSE; PHOSPHORYLATION; PROTEIN BINDING; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; ENZYME ACTIVATION; ENZYME ASSAYS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; MICE; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EID: 82155164068     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027488     Document Type: Article

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