β 2-adrenoceptor blockage induces G 1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway

Molecular Cancer

Volumn 10, Issue , 2011, Pages

  Zhang, Dong ^a   Ma, Qingyong ^a   Wang, Zheng ^a   Zhang, Min ^a   Guo, Kun ^a   Wang, Fengfei ^b   Wu, Erxi ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

adrenergic antagonists; Apoptosis; G1 s phase arrest; Ras

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CASPASE 3; CASPASE 9; CYCLIN D1; CYCLIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METOPROLOL; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; RAS PROTEIN; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL DEATH; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PANCREAS CANCER; PROTEIN EXPRESSION; RECEPTOR BLOCKING; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CELL CYCLE S PHASE; GENETICS; METABOLISM; NUDE MOUSE; PANCREAS TUMOR; PATHOLOGY; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-2 RECEPTOR ANTAGONISTS; ANIMALS; APOPTOSIS; G1 PHASE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NF-KAPPA B; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; RECEPTORS, ADRENERGIC, BETA; S PHASE; SIGNAL TRANSDUCTION;

EID: 82055171664     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-10-146     Document Type: Article

References (30)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009, 59:225-249. 10.3322/caac.20006, 19474385.
2. Raimondi S, Maisonneuve P, Lowenfels AB. Epidemiology of pancreatic cancer: an overview. Nat Rev Gastroenterol Hepatol 2009, 6:699-708. 10.1038/nrgastro.2009.177, 19806144.
3. Hidalgo M. Pancreatic cancer. N Engl J Med 2010, 362:1605-1617. 10.1056/NEJMra0901557, 20427809.
4. Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, McDonald PG, Stefanek M, Sood AK. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer 2006, 6:240-248. 10.1038/nrc1820, 3146042, 16498446.
5. Al-Wadei HA, Schuller HM. Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. J Pathol 2009, 218:437-445. 10.1002/path.2542, 19274673.
6. Davis R, Rizwani W, Banerjee S, Kovacs M, Haura E, Coppola D, Chellappan S. Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. PLoS One 2009, 4:e7524. 10.1371/journal.pone.0007524, 2759510, 19841737.
7. Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, Lu C, Jennings NB, Pena GA, Bankson JA, Ravoori M, Merritt WM, Lin YG, Mangala LS, Kim TJ, Coleman RL, Landen CN, Li Y, Felix E, Sanguino AM, Newman RA, Lloyd M, Gershenson DM, Kundra V, Lopez-Berestein G, Lutgendorf SK, Cole SW, Sood AK. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 2006, 12:939-944. 10.1038/nm1447, 16862152.
8. Sood AK, Bhatty R, Kamat AA, Landen CN, Han L, Thaker PH, Li Y, Gershenson DM, Lutgendorf S, Cole SW. Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res 2006, 2:369-375.
9. Wu WK, Wong HP, Luo SW, Chan K, Huang FY, Hui MK, Lam EK, Shin VY, Ye YN, Yang YH, Cho CH. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors. Cancer Res 2005, 65:5272-5277. 10.1158/0008-5472.CAN-05-0205, 15958573.
10. Schuller HM. Neurotransmission and cancer: implications for prevention and therapy. Anticancer Drugs 2008, 19:655-671. 10.1097/CAD.0b013e3283025b58, 18594207.
11. McGraw DW, Liggett SB. Molecular mechanisms of β2-adrenergic receptor function and regulation. Proc Am Thorac Soc 2005, 2:292-296. 10.1513/pats.200504-027SR, 2713324, 16267351.
12. Schuller HM, Al-Wadei HA. Neurotransmitter receptors as central regulators of pancreatic cancer. Future Oncol 2010, 6:221-228. 10.2217/fon.09.171, 2832917, 20146581.
13. Weddle DL, Tithoff P, Williams M, Schuller HM. Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. Carcinogenesis 2001, 22:473-479. 10.1093/carcin/22.3.473, 11238189.
14. Zhang D, Ma QY, Hu HT, Zhang M. Beta2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NF-kappaB and AP-1. Cancer Biol Ther 2010, 10:19-29. 10.4161/cbt.10.1.11944, 20424515.
15. Schuller HM. Mechanisms of smoking-related lung and pancreatic adenocarcinoma development. Nat Rev Cancer 2002, 2:455-463. 10.1038/nrc824, 12189387.
16. Askari MD, Tsao MS, Schuller HM. The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors. J Cancer Res Clin Oncol 2005, 131:639-648. 10.1007/s00432-005-0002-7, 16091975.
17. McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, David TM, Michele M, Agostino T, Franca S, Massimo L, Jorg B, Camilla E, Alberto MM, Richard AF. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 2007, 1773:1263-1284. 10.1016/j.bbamcr.2006.10.001, 2696318, 17126425.
18. Majidi M, Al-Wadei HA, Takahashi T, Schuller HM. Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells. Cancer Res 2007, 67:6863-6871. 10.1158/0008-5472.CAN-07-0483, 17638897.
19. Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J. The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. Oncogene 2004, 23:559-568.
20. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin FT, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ. β-Arrestin-dependent formation of β2 adrenergic receptor-src protein kinase complexes. Science 1999, 283:655-661. 10.1126/science.283.5402.655, 9924018.
21. Hirsch E, Ciraolo E, Ghigo A, Costa C. Taming the PI3K team to hold inflammation and cancer at bay. Pharmacol Therapeut 2008, 118:192-205.
22. Zhang D, Ma Q, Shen S, Hu H. Inhibition of pancreatic cancer cell proliferation by propranolol occurs through apoptosis induction: the study of beta-adrenoceptor antagonist's anticancer effect in pancreatic cancer cell. Pancreas 2009, 38:94-100. 10.1097/MPA.0b013e318184f50c, 19106745.
23. Hu HT, Ma QY, Zhang D, Shen SG, Han L, Ma YD, Li RF, Xie KP. HIF-1alpha links beta-adrenoceptor agonists and pancreatic cancer cells under normoxic condition. Acta Pharmacol Sin 2010, 31:102-110. 10.1038/aps.2009.181, 20037603.
24. Gardner-Thorpe J, Ito H, Ashley SW, Whang EE. Differential display of expressed genes in pancreatic cancer cells. Biochem Biophys Res Commun 2002, 293:391-395. 10.1016/S0006-291X(02)00237-1, 12054612.
25. Chen ZB, Liu C, Chen FQ, Li SY, Liang Q, Liu LY. Effects of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the activation of ERK1/2 MAP kinases and the proliferation of human mammary epithelial cells. Environ Toxicol Pharmacol 2006, 22:283-291. 10.1016/j.etap.2006.04.001, 21783722.
26. Foster I. Cancer: A cell cycle defect. Radiography 2008, 14:144-149.
27. Leicht DT, Balan V, Kaplun A, Singh-Gupta V, Kaplun L, Dobson M, Guri T. Raf kinases: Function, regulation and role in human cancer. Biochim Biophys Acta 2007, 1773:1196-1212. 10.1016/j.bbamcr.2007.05.001, 1986673, 17555829.
28. Weyden L, Adams DJ. The Ras-association domain family (RASSF) members and their role in human tumourigenesis. Biochim Biophys Acta 2007, 1776:58-85. 2586335,2586335, 17692468.
29. Chambard JC, Lefloch R, Pouysségur J, Lenormand P. ERK implication in cell cycle regulation. Biochim Biophys Acta 2007, 1773:1299-1310. 10.1016/j.bbamcr.2006.11.010, 17188374.
30. Herr I, Debatin KM. Cellular stress response and apoptosis in cancer therapy. Blood 2001, 98:2603-2614. 10.1182/blood.V98.9.2603, 11675328.