IGF-1 delivery to CNS attenuates motor neuron cell death but does not improve motor function in type III SMA mice

Neurobiology of Disease

Volumn 45, Issue 1, 2012, Pages 272-279

  Tsai, Li Kai ^a,b   Chen, Yi Chun ^a   Cheng, Wei Cheng ^c   Ting, Chen Hung ^c   Dodge, James C ^d   Hwu, Wuh Liang ^b   Cheng, Seng H ^d   Passini, Marco A ^d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^d Genzyme   (United States)

Author keywords

Adeno associated virus; Bax; Bcl xl; Gene therapy; Motor neuron disease; Spinal muscular atrophy

Indexed keywords

PARVOVIRUS VECTOR; PROTEIN BAX; PROTEIN BCL XL; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEATH; CELL LOSS; CEREBELLUM NUCLEUS; CONTROLLED STUDY; DRUG EFFICACY; MOTONEURON; MOTOR PERFORMANCE; MOUSE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SPINAL MUSCULAR ATROPHY; TREATMENT RESPONSE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CELL DEATH; CEREBELLUM; GENE THERAPY; GENETIC VECTORS; INSULIN-LIKE GROWTH FACTOR I; MICE; MOTOR ACTIVITY; MOTOR NEURONS; MUSCLE FIBERS, SKELETAL; MUSCULAR ATROPHY, SPINAL; SPINAL CORD;

EID: 81955167497     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.06.021     Document Type: Article

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