Neurodevelopmental liability to schizophrenia: The complex mediating role of age at onset and premorbid adjustment

Schizophrenia Research

Volumn 133, Issue 1-3, 2011, Pages 143-149

  Goldberg, X ^a,b   Fatjo Vilas M ^a,b   Penades R ^b,c   Miret, S ^d   Muñoz, M J ^e   Vossen, H ^a,b   Fananas L ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

^d Hospital Santa Maria   (Spain)

^e Sant Boi de Llobregat ^*  (Spain)

Author keywords

Age at onset; Neurodevelopment; Path analysis; Premorbid adjustment; Schizophrenia

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EDUCATIONAL STATUS; FAMILY HISTORY; FAMILY STUDY; FEMALE; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; NERVOUS SYSTEM DEVELOPMENT; NEUROBIOLOGY; ONSET AGE; PARSIMONY ANALYSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; PSYCHOSIS; SCHIZOPHRENIA; SEX DIFFERENCE; SPAIN;

ADAPTATION, PSYCHOLOGICAL; ADOLESCENT; ADULT; AGE OF ONSET; COGNITION DISORDERS; DEVELOPMENTAL DISABILITIES; FAMILY HEALTH; FEMALE; HUMANS; MALE; MODELS, STATISTICAL; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; YOUNG ADULT;

EID: 81955161946     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2011.09.014     Document Type: Article

References (67)

1. Ammari N., Heinrichs R.W., Miles A.A. An investigation of 3 neurocognitive subtypes in schizophrenia. Schizophr. Res. 2010, 121(1-3):32-38.
2. Andreasen N.C. Schizophrenia: the fundamental questions. Brain Res. Brain Res. Rev. 2000, 31(2-3):106-112.
3. Andreasen N.C., Flaum M., Arndt S. The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch. Gen. Psychiatry 1992, 49(8):615-623.
4. Arnold S.E., Talbot K., Hahn C.G. Neurodevelopment, neuroplasticity, and new genes for schizophrenia. Prog. Brain Res. 2005, 147:319-345.
5. Bowie C.R., Leung W.W., Reichenberg A., Mcclure M.M., Patterson T.L., Heaton R.K., Harvey P.D. Predicting schizophrenia patients' real-world behavior with specific neuropsychological and functional capacity measures. Biol. Psychiatry 2008, 63(5):505-511.
6. Brekke J., Kay D.D., Lee K.S., Green M.F. Biosocial pathways to functional outcome in schizophrenia. Schizophr. Res. 2005, 80(2-3):213-225.
7. Byrne B. Structural equation modeling with AMOS: basic concepts, applications, and programming 2010, Taylor & Francis Group, New york. 2ō edition.
8. Cannon M., Caspi A., Moffitt T.E., Harrington H., Taylor A., Murray R.M., Poulton R. Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort. Arch. Gen. Psychiatry 2002, 59(5):449-456.
9. Cannon-Spoor H.E., Potkin S.G., Wyatt R.J. Measurement of premorbid adjustment in chronic schizophrenia. Schizophr. Bull. 1982, 8(3):470-484.
10. Cardno A.G., Holmans P.A., Rees M.I., Jones L.A., Mccarthy G.M., Hamshere M.L., Williams N.M., Norton N., Williams H.J., Fenton I., Murphy K.C., Sanders R.D., Gray M.Y., O'donovan M.C., Mcguffin P., Owen M.J. A genomewide linkage study of age at onset in schizophrenia. Am. J. Med. Genet. 2001, 105(5):439-445.
11. Carpenter W.T., Heinrichs D.W., Wagman A.M. Deficit and nondeficit forms of schizophrenia: the concept. Am. J. Psychiatry 1988, 145(5):578-583.
12. Castle D.J., Murray R.M. The neurodevelopmental basis of sex differences in schizophrenia. Psychol. Med. 1991, 21(3):565-575.
13. Couture S.M., Granholm E.L., Fish S.C. A path model investigation of neurocognition, theory of mind, social competence, negative symptoms and real-world functioning in schizophrenia. Schizophr. Res. 2011, 125(2-3):152-160.
14. Crow T.J. Positive and negative schizophrenic symptoms and the role of dopamine. Br. J. Psychiatry 1980, 137:383-386.
15. Delisi L.E. The significance of age of onset for schizophrenia. Schizophr. Bull. 1992, 18(2):209-215.
16. Delisi L.E. Is schizophrenia a lifetime disorder of brain plasticity, growth and aging?. Schizophr. Res. 1997, 23(2):119-129.
17. Delisi L.E., Goldin L.R., Maxwell M.E., Kazuba D.M., Gershon E.S. Clinical features of illness in siblings with schizophrenia or schizoaffective disorder. Arch. Gen. Psychiatry 1987, 44(10):891-896.
18. Delisi L.E., Bass N., Boccio A., Shields G., Morganti C. Age of onset in familial schizophrenia. Arch. Gen. Psychiatry 1994, 51(4):334-335.
19. Dominguez Mdeg, Viechtbauer W., Simons C.J., Van Os J., Krabbendam L. Are psychotic psychopathology and neurocognition orthogonal? A systematic review of their associations. Psychol. Bull. 2009, 135(1):157-171.
20. Egan M.F., Goldberg T.E., Gscheidle T., Weirich M., Rawlings R., Hyde T.M., Bigelow L., Weinberger D.R. Relative risk for cognitive impairments in siblings of patients with schizophrenia. Biol. Psychiatry 2001, 50(2):98-107.
21. Esterberg M.L., Trotman H.D., Holtzman C., Compton M.T., Walker E.F. The impact of a family history of psychosis on age-at-onset and positive and negative symptoms of schizophrenia: a meta-analysis. Schizophr. Res. 2010, 120(1-3):121-130.
22. Geller B., Williams M., Zimmerman B., Frazier J. Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) 1996, Washington University, St. Louis.
23. Gharaibeh W.S., Rohlf F.J., Slice D.E., Delisi L.E. A geometric morphometric assessment of change in midline brain structural shape following a first episode of schizophrenia. Biol. Psychiatry 2000, 48(5):398-405.
24. Goldberg T., Green M. Neurocognitive function in patients with schizophrenia: an overview. Neuropsychopharmacology: The Fifth Generation of Progress 2002, American College of Neuropsychopharmacology. K.L. Davis (Ed.).
25. Goldberg X., Fatjó-Vilas M., Muñoz M.J., Campanera S., Miret S., Miñano M.J., Aguilera M., Miralles M.L., Navarro M.E., Lázaro L., Guitart M., Barrantes-Vidal N., Fañanás L. Increased familiarity of intellectual deficits in early-onset schizophrenia spectrum disorders. World J. Biol. Psychiatry 2011, 1-8.
26. Groom M.J., Jackson G.M., Calton T.G., Andrews H.K., Bates A.T., Liddle P.F., Hollis C. Cognitive deficits in early-onset schizophrenia spectrum patients and their non-psychotic siblings: a comparison with ADHD. Schizophr. Res. 2008, 99(1-3):85-95.
27. Harvey P.D., Koren D., Reichenberg A., Bowie C.R. Negative symptoms and cognitive deficits: what is the nature of their relationship?. Schizophr. Bull. 2006, 32(2):250-258.
28. Hollis C. Adolescent schizophrenia. Adv. Psychiatr. Treat. 2000, 683-692.
29. Hooper S.R., Giuliano A.J., Youngstrom E.A., Breiger D., Sikich L., Frazier J.A., Findling R.L., Mcclellan J., Hamer R.M., Vitiello B., Lieberman J.A. Neurocognition in early-onset schizophrenia and schizoaffective disorders. J. Am. Acad. Child Adolesc. Psychiatry 2010, 49(1):52-60.
30. Jablensky A. Subtyping schizophrenia: implications for genetic research. Mol. Psychiatry 2006, 11(9):815-836.
31. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 1987, 13(2):261-276.
32. Keshavan M.S., Delisi L.E., Seidman L.J. Early and broadly defined psychosis risk mental states. Schizophr. Res. 2011, 126(1-3):1-10.
33. Keshavan M.S., Nasrallah H.A., Tandon R. Schizophrenia, "Just the Facts" 6. Moving ahead with the schizophrenia concept: from the elephant to the mouse. Schizophr. Res. 2011, 127(1-3):3-13.
34. Koenen K.C., Moffitt T.E., Roberts A.L., Martin L.T., Kubzansky L., Harrington H., Poulton R., Caspi A. Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis. Am. J. Psychiatry 2009, 166(1):50-57.
35. Kyriakopoulos M., Frangou S. Pathophysiology of early onset schizophrenia. Int. Rev. Psychiatry 2007, 19(4):315-324.
36. Larsen T.K., Friis S., Haahr U., Johannessen J.O., Melle I., Opjordsmoen S., Rund B.R., Simonsen E., Vaglum P.V., Mcglashan T.H. Premorbid adjustment in first-episode non-affective psychosis: distinct patterns of pre-onset course. Br. J. Psychiatry 2004, 185:108-115.
37. Leifker F.R., Bowie C.R., Harvey P.D. Determinants of everyday outcomes in schizophrenia: the influences of cognitive impairment, functional capacity, and symptoms. Schizophr. Res. 2009, 115(1):82-87.
38. Leung A., Chue P. Sex differences in schizophrenia, a review of the literature. Acta Psychiatr. Scand. Suppl. 2000, 401:3-38.
39. Li X., Sundquist J., Sundquist K. Age-specific familial risks of psychotic disorders and schizophrenia: a nation-wide epidemiological study from Sweden. Schizophr. Res. 2007, 97(1-3):43-50.
40. Malaspina D., Goetz R.R., Yale S., Berman A., Friedman J.H., Tremeau F., Printz D., Amador X., Johnson J., Brown A., Gorman J.M. Relation of familial schizophrenia to negative symptoms but not to the deficit syndrome. Am. J. Psychiatry 2000, 157(6):994-1003.
41. Maxwell M.E. Family Interview for Genetic Studies (FIGS): A Manual for FIGS, Clinical Neurogenetics Branch, Intramural Research Program 1992, National Institute of Mental Health, Bethesda, Maryland.
42. Mojtabai R., Malaspina D., Susser E. The concept of population prevention: application to schizophrenia. Schizophr. Bull. 2003, 29(4):791-801.
43. Murray R.M., O'callaghan E., Castle D.J., Lewis S.W. A neurodevelopmental approach to the classification of schizophrenia. Schizophr. Bull. 1992, 18(2):319-332.
44. Myin-Germeys I., Van Os J. Stress-reactivity in psychosis: evidence for an affective pathway to psychosis. Clin. Psychol. Rev. 2007, 27(4):409-424.
45. Nam H.J., Kim N., Park T., Oh S., Jeon H.O., Yoon S.C., Lee Y.S., Lee W.K., Ha K., Kim J.H., Hong K.S. Cognitive profiles of healthy siblings of schizophrenia patients: application of the cognitive domains of the MATRICS consensus battery. World J. Biol. Psychiatry 2009, 10(4 Pt 2):452-460.
46. Nicolson R., Lenane M., Singaracharlu S., Malaspina D., Giedd J.N., Hamburger S.D., Gochman P., Bedwell J., Thaker G.K., Fernandez T., Wudarsky M., Hommer D.W., Rapoport J.L. Premorbid speech and language impairments in childhood-onset schizophrenia: association with risk factors. Am. J. Psychiatry 2000, 157(5):794-800.
47. Nicolson R., Brookner F.B., Lenane M., Gochman P., Ingraham L.J., Egan M.F., Kendler K.S., Pickar D., Weinberger D.R., Rapoport J.L. Parental schizophrenia spectrum disorders in childhood-onset and adult-onset schizophrenia. Am. J. Psychiatry 2003, 160(3):490-495.
48. Norman R.M., Malla A.K., Manchanda R., Townsend L. Premorbid adjustment in first episode schizophrenia and schizoaffective disorders: a comparison of social and academic domains. Acta Psychiatr. Scand. 2005, 112(1):30-39.
49. O'donovan M.C., Norton N., Williams H., Peirce T., Moskvina V., Nikolov I., Hamshere M., Carroll L., Georgieva L., Dwyer S., Holmans P., Marchini J.L., Spencer C.C., Howie B., Leung H.T., Giegling I., Hartmann A.M., Moller H.J., Morris D.W., Shi Y., Feng G., Hoffmann P., Propping P., Vasilescu C., Maier W., Rietschel M., Zammit S., Schumacher J., Quinn E.M., Schulze T.G., Iwata N., Ikeda M., Darvasi A., Shifman S., He L., Duan J., Sanders A.R., Levinson D.F., Adolfsson R., Osby U., Terenius L., Jonsson E.G., Cichon S., Nothen M.M., Gill M., Corvin A.P., Rujescu D., Gejman P.V., Kirov G., Craddock N., Williams N.M., Owen M.J. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Mol. Psychiatry 2009, 14(1):30-36.
50. Palmer B.W., Dawes S.E., Heaton R.K. What do we know about neuropsychological aspects of schizophrenia?. Neuropsychol. Rev. 2009, 19(3):365-384.
51. Perkins D.O., Leserman J., Jarskog L.F., Graham K., Kazmer J., Lieberman J.A. Characterizing and dating the onset of symptoms in psychotic illness: the Symptom Onset in Schizophrenia (SOS) inventory. Schizophr. Res. 2000, 44(1):1-10.
52. Preston N.J., Orr K.G., Date R., Nolan L., Castle D.J. Gender differences in premorbid adjustment of patients with first episode psychosis. Schizophr. Res. 2002, 55(3):285-290.
53. Rajji T.K., Ismail Z., Mulsant B.H. Age at onset and cognition in schizophrenia: meta-analysis. Br. J. Psychiatry 2009, 195(4):286-293.
54. Rapoport J.L., Addington A.M., Frangou S., Psych M.R. The neurodevelopmental model of schizophrenia: update 2005. Mol. Psychiatry 2005, 10(5):434-449.
55. Rapoport J., Chavez A., Greenstein D., Addington A., Gogtay N. Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited. J. Am. Acad. Child Adolesc. Psychiatry 2009, 48(1):10-18.
56. Ritsner M., Ratner Y., Gibel A., Weizman R. Familiality in a five-factor model of schizophrenia psychopathology: findings from a 16-month follow-up study. Psychiatry Res. 2005, 136(2-3):173-179.
57. Schmael C., Georgi A., Krumm B., Buerger C., Deschner M., Nothen M.M., Schulze T.G., Rietschel M. Premorbid adjustment in schizophrenia - an important aspect of phenotype definition. Schizophr. Res. 2007, 92(1-3):50-62.
58. Shrout P.E., Bolger N. Mediation in experimental and nonexperimental studies: new procedures and recommendations. Psychol. Methods 2002, 7(4):422-445.
59. Silk T.J., Wood A.G. Lessons about neurodevelopment from anatomical magnetic resonance imaging. J. Dev. Behav. Pediatr. 2011, 32(2):158-168.
60. Tandon R., Nasrallah H.A., Keshavan M.S. Schizophrenia, "just the facts" 5. Treatment and prevention. Past, present, and future. Schizophr. Res. 2010, 122(1-3):1-23.
61. Taylor D.C. Differential rates of cerebral maturation between sexes and between hemispheres. Evidence from epilepsy. Lancet 1969, 2(7612):140-142.
62. Vazquez-Barquero J.L., Lastra I., Cuesta Nunez M.J., Herrera Castanedo S., Dunn G. Patterns of positive and negative symptoms in first episode schizophrenia. Br. J. Psychiatry 1996, 168(6):693-701.
63. Verdoux H., Van Os J., Sham P., Jones P., Gilvarry K., Murray R. Does familiality predispose to both emergence and persistence of psychosis? A follow-up study. Br. J. Psychiatry 1996, 168(5):620-626.
64. Walshe M., Taylor M., Schulze K., Bramon E., Frangou S., Stahl D., Kravariti E., Daly E., Fearon P., Murray R.M., Mcdonald C. Familial liability to schizophrenia and premorbid adjustment. Br. J. Psychiatry 2007, 191:260-261.
65. Wechsler D. Wechsler Intelligence Scale for Children 1991, The Psychological Corporation, San Antonio, TX. Third edition.
66. Wechsler D. WMS-III. Wechsler Memory Scale 1997, The Psychological Corporation, San Antonio, TX. Third edition.
67. Wechsler D. Wechsler Adult Intelligence Scale. Administration and Scoring Manual 1997, The Psychological Corporation, London. Third edition.