Propranolol enhances cell cycle-related gene expression in pressure overloaded hearts

British Journal of Pharmacology

Volumn 164, Issue 8, 2011, Pages 1917-1928

  Musumeci, Marco ^a   MacCari, Sonia ^a   Sestili, Paola ^a   Signore, Michele ^a   Molinari, Paola ^a   Ambrosio, Caterina ^a   Stati, Tonino ^a   Colledge, William H ^c   Grace, Andrew A ^c   Catalano, Liviana ^b   Marano, Giuseppe ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b National Blood Center   (Italy)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

adrenoceptor antagonist; cell cycle; gene expression; heart; hypertrophy; pressure overload

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BRCA1 PROTEIN; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLINE; DRINKING WATER; ISOPRENALINE; KI 67 ANTIGEN; METOPROLOL; PROPRANOLOL; RAD51 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; BODY WEIGHT; CELL COUNT; CELL CYCLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG BLOOD LEVEL; FIBROBLAST; GENE DELETION; GENE EXPRESSION; HEART LEFT VENTRICLE OVERLOAD; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; GENE EXPRESSION REGULATION; GENES, CDC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; PROPRANOLOL; RADIOLIGAND ASSAY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ADRENERGIC, BETA;

EID: 81855228897     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01504.x     Document Type: Article

References (24)

1. Angelis E, Garcia A, Chan AS, Schenke-Layland K, Ren S, Goodfellow SJ, et al,. (2008). A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Circ Res 102: 1222-1229.
2. sα mouse. J Clin Invest 104: 551-558.
3. Baumhäkel M, Schlimmer N, Büyükafar K, Arikan O, Böhm M, (2008). Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein E-knockout mice. J Pharmacol Exp Ther 325: 818-823. (Pubitemid 351728031)
4. Bernstein D, Fajardo G, Zhao M, Urashima T, Powers J, Berry G, et al,. (2005). Differential cardioprotective/cardiotoxic effects mediated by β-adrenergic receptor subtypes. Am J Physiol 289: H2441-H2449. (Pubitemid 41698555)
5. Busk PK, Bartkova J, Strøm CC, Wulf-Andersen L, Hinrichsen R, Christoffersen TE, et al,. (2002). Involvement of cyclin D activity in left ventricle hypertrophy in vivo and in vitro. Cardiovasc Res 56: 64-75. (Pubitemid 35247803)
6. DeLean A, Munson PJ, Rodbard D, (1978). Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 235: E97-E102. (Pubitemid 9159876)
7. Elkins RP, Kelly JF, Rosenberg BJ, (1986). A radioreceptor assay in which lodocyanopindolol is used to determine propranolol and its active metabolites in unextracted serum or plasma. Clin Chem 32: 180-183. (Pubitemid 17033806)
8. Hinrichsen R, Hansen AH, Haunsø S, Busk PK, (2008). Phosphorylation of pRb by cyclin D kinase is necessary for development of cardiac hypertrophy. Cell Prolif 41: 813-829.
9. Kong Y, Tannous P, Lu G, Berenji K, Rothermel BA, Olson EN, et al,. (2006). Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. Circulation 113: 2579-2588. (Pubitemid 43948006)
10. Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, et al,. (2002). Transforming growth factor-β function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation 106: 130-135. (Pubitemid 34747453)
11. Li JM, Poolman RA, Brooks G, (1998). Role of G1 phase cyclins and cyclin-dependent kinases during cardiomyocyte hypertrophic growth in rats. Am J Physiol 275: H814-H822.
12. Marano G, Palazzesi S, Fadda A, Vergari A, Ferrari AU, (2002). Attenuation of aortic banding-induced cardiac hypertrophy by propranolol is independent of β-adrenoceptor blockade. J Hypertens 20: 763-769. (Pubitemid 34913722)
13. Marano G, Vergari A, Catalano L, Gaudi S, Palazzesi S, Musumeci M, et al,. (2004). Na/H exchange inhibition attenuates left ventricular remodeling and preserves systolic function in pressure-overloaded hearts. Br J Pharmacol 141: 526-532. (Pubitemid 38297015)
14. Murray KT, Reilly C, Koshakji RP, Roden DM, Lineberry MD, Wood AJ, et al,. (1990). Suppression of ventricular arrhythmias in man by d-propranolol independent of beta-adrenergic receptor blockade. J Clin Invest 85: 836-842. (Pubitemid 20087487)
15. Nozato T, Ito H, Watanabe M, Ono Y, Adachi S, Tanaka H, et al,. (2001). Overexpression of cdk Inhibitor p16INK4a by adenovirus vector inhibits cardiac hypertrophy in vitro and in vivo: a novel strategy for the gene therapy of cardiac hypertrophy. J Mol Cell Cardiol 33: 1493-1504. (Pubitemid 32681667)
16. Ostman-Smith I, (1995). Reduction by oral propranolol treatment of left ventricular hypertrophy secondary to pressure-overload in the rat. Br J Pharmacol 116: 2703-2709.
17. Papadatos GA, Wallerstein PM, Head CE, Ratcliff R, Brady PA, Benndorf K, et al,. (2002). Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A 99: 6210-6215. (Pubitemid 34493291)
18. Patrizio M, Musumeci M, Stati T, Fasanaro P, Palazzesi S, Catalano L, et al,. (2007). Propranolol causes a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli. Br J Pharmacol 152: 216-222. (Pubitemid 47517602)
19. Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, et al,. (1991). Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A 88: 8277-8281. (Pubitemid 21915339)
20. 2-adrenergic receptors. J Biol Chem 274: 16701-16708.
21. Schmittgen TD, Livak KJ, (2008). Analyzing real-time PCR data by the comparative CT method. Nat Protoc 3: 1101-1108. (Pubitemid 351818697)
22. Strack I, Schulte S, Varnholt H, Schievenbusch S, Töx U, Wendland K, et al,. (2011). β-Adrenoceptor blockade in sclerosing cholangitis of Mdr2 knockout mice: antifibrotic effects in a model of nonsinusoidal fibrosis. Lab Invest 91: 252-261.
23. Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, et al,. (2010). Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest 120: 254-265.
24. Wagner RA, Tabibiazar R, Powers J, Bernstein D, Quertermous T, (2004). Genome-wide expression profiling of a cardiac pressure overload model identifies major metabolic and signaling pathway responses. J Mol Cell Cardiol 37: 1159-1170. (Pubitemid 39575161)