Rescue of severe infantile hypophosphatasia mice by AAV-mediated sustained expression of soluble alkaline phosphatase

Human Gene Therapy

Volumn 22, Issue 11, 2011, Pages 1355-1364

  Matsumoto, Tae ^a   Miyake, Koichi ^a   Yamamoto, Seiko ^a,b   Orimo, Hideo ^a   Miyake, Noriko ^a   Odagaki, Yuko ^a   Adachi, Kumi ^a   Iijima, Osamu ^a   Narisawa, Sonoko ^b   Millán, José Luis ^b   Fukunaga, Yoshitaka ^a   Shimada, Takashi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTIC ACID; CELL PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; PARVOVIRUS VECTOR; PROTEIN AKP2; TISSUE NONSPECIFIC ALKALINE PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MINERALIZATION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; GENE THERAPY; GENOME; HUMAN; HUMAN CELL; HYPOPHOSPHATASIA; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; SEIZURE; SEROTYPE; SURVIVAL RATE; X RAY ANALYSIS;

ALKALINE PHOSPHATASE; ANIMALS; ANIMALS, NEWBORN; CELL LINE; DEPENDOVIRUS; GENE THERAPY; HUMANS; HYPOPHOSPHATASIA; MICE; MICE, KNOCKOUT; PHENOTYPE;

ADENO-ASSOCIATED VIRUS; ANIMALIA; MUS;

EID: 81855216435     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2010.210     Document Type: Article

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