Improved efficacy of therapeutic vaccination with dendritic cells pulsed with tumor cell lysate against hepatocellular carcinoma by introduction of 2 tandem repeats of microbial HSP70 peptide epitope 407-426 and OK-432

International Immunopharmacology

Volumn 11, Issue 12, 2011, Pages 2200-2207

  Ge, Chiyu ^a   Xing, Yun ^a   Wang, Qi ^a   Xiao, Wen ^a   Lu, Yong ^a   Hu, Xiangbing ^a   Gao, Zhenqiu ^a   Xu, Maolei ^a   Ma, Yanjun ^a   Cao, Rongyue ^a   Liu, Jingjing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

2mHSP70 407 426; Dendritic cell vaccination; Hepatocellular carcinoma immunotherapy; OK 432

Indexed keywords

B7 ANTIGEN; CANCER VACCINE; CD40 ANTIGEN; CD86 ANTIGEN; DENDRITIC CELL VACCINE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; HEAT SHOCK PROTEIN 70; INTERLEUKIN 12; INTERLEUKIN 5; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE DERIVATIVE; PICIBANIL; TUMOR CELL LYSATE VACCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CELL LYSATE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG POTENCY; IMMUNIZATION; LIVER CELL CARCINOMA; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; TANDEM REPEAT; TH1 CELL; TH2 CELL; THERAPY EFFECT; TUMOR CELL; TUMOR GROWTH;

ANIMALS; CANCER VACCINES; CARCINOMA, HEPATOCELLULAR; CYTOKINES; DENDRITIC CELLS; EPITOPES; HSP70 HEAT-SHOCK PROTEINS; LIVER NEOPLASMS, EXPERIMENTAL; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; PICIBANIL; T-LYMPHOCYTES, CYTOTOXIC; TANDEM REPEAT SEQUENCES; TREATMENT OUTCOME;

EID: 81855204935     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.10.001     Document Type: Article

References (36)

1. R. Wong, and C. Frenette Updates in the management of hepatocellular carcinoma Gastroenterol Hepatol (NY) 7 2011 16 24
2. J. Whang-Peng, C. Ann-Lii, C. Hsu, and C. Chien-Ming Clinical development and future direction for the treatment of hepatocellular carcinoma J Exp Clin Med 2 2010 93 103
3. J. Yamamoto, T. Kosuge, T. Takayama, K. Shimada, S. Yamasaki, and H. Ozaki Recurrence of hepatocellular carcinoma after surgery Br J Surg 83 1996 1219 1222 (Pubitemid 26290448)
4. C. Zhang, and E.G. Engleman Mechanisms of action of dendritic cell vaccines for the treatment of cancer Drug Discov Today 3 2006 213 218 (Pubitemid 44356307)
5. K. Mahnke, E. Schmitt, L. Bonifaz, A.H. Enk, and H. Jonuleit Immature, but not inactive: the tolerogenic function of immature dendritic cells Immunol Cell Biol 80 2002 477 483
6. K. Skalova, K. Mollova, and J. Michalek Human myeloid dendritic cells for cancer therapy: Does maturation matter? Vaccine 28 2010 5153 5160
7. K. Sun, L. Wang, and Y. Zhang Dendritic cell as therapeutic vaccines against tumors and its role in therapy for hepatocellular carcinoma Cell Mol Immunol 3 2006 197 203
8. W.C. Lee, H.C. Wang, C.F. Hung, P.F. Huang, C.R. Lia, and M.F. Chen Vaccination of advanced hepatocellular carcinoma patients with tumor lysate-pulsed dendritic cells: a clinical trial J Immunother 28 2005 496 504
9. K. Pan, J.J. Zhao, H. Wang, J.J. Li, X.T. Liang, and J.C. Sun Comparative analysis of cytotoxic T lymphocyte response induced by dendritic cells loaded with hepatocellular carcinoma derived RNA or cell lysate Int J Biol Sci 6 2010 639 648
10. Y. Iwashita, K. Tahara, S. Goto, A. Sasaki, S. Kai, and M. Seike A phase I study of autologous dendritic cell-based immunotherapy for patients with unresectable primary liver cancer Cancer Immunol Immunother 52 2003 155 161 (Pubitemid 36384715)
11. B.K. Cho, D. Palliser, E. Guillen, J. Wisniewski, R.A. Young, and J. Chen A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins Immunity 12 2000 263 272
12. R.M. Vabulas, P. Ahmad-Nejad, S. Ghose, C.J. Kirshning, R.D. Issels, and H. Wagner HSP70 as endogenous stimulus of the Toll / interleukin-1 receptor signal pathway J Biol Chem 277 2002 15107 15112 (Pubitemid 34952589)
13. Y. Wang, T. Whittall, E. McGowan, J. Younson, C. Kelly, and L.A. Bergmeier Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells J Immunol 174 2005 3306 3316 (Pubitemid 40354034)
14. Y. Lu, K. Ouyang, J. Fang, H. Zhang, G. Wu, and Y. Ma Improved efficacy of DNA vaccination against prostate carcinoma by boosting with recombinant protein vaccine and by introduction of a novel adjuvant epitope Vaccine 27 2009 5411 5418
15. M. Okamoto, S. Furuichi, Y. Nishioka, T. Oshikawa, T. Tano, and S.U. Ahmed Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streotococcal preparation Cancer Res 64 2004 5461 5470 (Pubitemid 39006570)
16. T. Ono, S. Kurata, K. Wakabayashi, Y. Sugawara, and M. Satio Inhibitory effect of a streptococcal preparation (OK-432) on the nucleic acid synthesis in tumor cells in vitro Gann 64 1973 59 64
17. C. Olsnes, H. Stavang, K. Brokstad, J. Olofsson, and H.J. Aarstad Chemokines are secreted by monocytes following OK-432 (lyophilized Streptococcus pyogenes) stimulation BMC Immunol 10 2009 6
18. K.S. Hill, F. Errington, L.P. Steele, A. Merrick, R. Morgan, and P.J. Selby OK432-activated human dendritic cells kill tumor cells via CD40/CD40 ligand interactions J Immunol 181 2008 3108 3115
19. L. Holtl, C. Zelle-Rieser, H. Gander, C. Papesh, R. Ramoner, and H. Bartsch Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells Clin Cancer Res 8 2002 3369 3376 (Pubitemid 35340710)
20. K. Inaba, M. Inaba, N. Romani, H. Aya, M. Deguchi, and S. Ikehara Generation of large number of dendritic cells from mouse bone marrow cultures supplemented with granulocyte / macrophage colony-stimulating factor J Exp Med 176 1992 1693 1702
21. X. Hu, Y. Zhang, M. Ling, Y. Lu, Y. Zhang, and H. Zhang The fusion protein of HSP65 with tandem repeats of β-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma Int Immunopharmacol 10 2010 230 238
22. K. Sarkar, S. Goswami, S. Roy, A. Mallick, K. Chakraborty, and A. Bose Neem leaf glycoprotein enhances carcinoembryonic antigen presentation of dendritic cells to T and B cells for induction of anti-tumor immunity by allowing generation of immune effector/memory response Int Immunopharmacol 10 2010 865 874
23. J. Zhou, Z.Y. Tang, J. Fan, Z.Q. Wu, X.M. Li, and Y.K. Liu Expression of platelet-derived endothelial cell growth factor and vascular endothelial growth factor in hepatocellular carcinoma and portal vein tumor thrombus J Cancer Res Clin Oncol 126 2000 57 61 (Pubitemid 30006353)
24. T. Nakamura, K. Sakai, T. Nakamura, and K. Matsumoto Hepatocyte growth factor twenty years on: Much more than a growth factor J Gastroenterol Hepatol 26 Suppl. 1 2011 188 202
25. Y. Wang, C.G. Kelly, M. Singh, E.G. McGowan, A.S. Carrara, and L.A. Bergmeier Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells, and adjuvant function by the peptide binding fragment of heat shock protein 70 J Immunol 169 2002 2422 2429 (Pubitemid 34920985)
26. Y. Lu, H. Zhang, J. Hou, H. Wang, X. Hu, and Y. Ma Vaccination with a potent DNA vaccine targeting B-cell epitopes of hGRP induces prophylactic and therapeutic antitumor activity in vivo Gene Ther 17 2010 459 468
27. Y. Lu, D.J. Mekoo, K. Ouyang, X. Hu, Y. Liu, and M. Lin Strong humoral response elicited by a DNA vaccine targeting gastrin-releasing peptide with optimized adjuvants inhibits murine prostate carcinoma growth in vivo Endocr Relat Cancer 16 2009 1171 1184
28. S. Koido, E. Hara, S. Homma, A. Torii, M. Mitsunaga, and S. Yanagisawa Streptococcal preparation OK-432 promotes fusion efficiency and enhances induction of antigen-specific CTL by fusions of dendritic cells and colorectal cancer cells J Immunol 178 2007 613 622 (Pubitemid 46033645)
29. K. Mashino, N. Sadanaga, F. Tanaka, M. Ohta, H. Yamaguchi, and M. Mori Effective strategy of dendritic cell-based immunotherapy for advanced tumor-bearing hosts: the critical role of Th1-dominant immunity Mol Cancer Ther 1 2002 785 794
30. S. Nakahara, T. Tsunoda, T. Baba, S. Asabe, and H. Tahara Dendritic Cells Stimulated with a bacterial product, OK-432, efficiently induce cytotoxic T lymphocytes specific to tumor rejection peptide Cancer Res 63 2003 4112 4118 (Pubitemid 36917935)
31. H. Jonuleit, A.G. Tuettenberg, T. Tuting, B.T. Schuler, T.B. Stuge, and L. Paragnik A comparison of two types of dendritic cells as adjuvants for the induction of melanoma-specific T-cell responses in human following intranodal injection Int J Cancer 93 2001 243 251 (Pubitemid 32574281)
32. H. Jonuleit, U. Kuhn, G. Muller, K. Steinbrink, L. Paragnik, and E. Schmitt Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions Eur J Immunol 27 1997 3135 3142 (Pubitemid 28018007)
33. M.J. Estcourt, A. Ramshaw, and A.J. Ramsay Cytokine responses in virus infections: effects on pathogenesis, recovery and persistence Curr Opin Microbiol 1 1998 411 418 (Pubitemid 128423255)
34. E.S. Schultz, J. Chapiro, C. Lurquin, S. Claverol, O. Burlet-Schiltz, and G. Warnier The production of a new MAGE-3 peptide presented to cytolytic T lymphocytes by HLA-B40 requires the immunoproteasome J Exp Med 195 2002 391 399 (Pubitemid 34461293)
35. D.S. Robinson, and A. O'Garra Further checkpoints in Th1 development Immunity 16 2002 755 758 (Pubitemid 34786474)
36. M. Moutaftsi, A.M. Mehl, L.K. Borysiewicz, and Z. Tabi Human cytomegalovirus inhibits maturation and impairs function of monocyte-derived dendritic cells Blood 99 2002 2913 2921 (Pubitemid 34525381)