Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells

Journal of Immunology

Volumn 174, Issue 6, 2005, Pages 3306-3316

  Wang, Yufei ^a   Whittall, Trevor ^a   McGowan, Edward ^a   Younson, Justine ^a   Kelly, Charles ^a   Bergmeier, Lesley A ^a   Singh, Mahavir ^b   Lehner, Thomas ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b LIONEX DIAGNOSTICS AND THERAPEUTICS GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; CYTOKINE; EPITOPE; HEAT SHOCK PROTEIN 70; INTERLEUKIN 12; MITOGEN ACTIVATED PROTEIN KINASE P38; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN DETECTION; ARTICLE; CELL MATURATION; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME PHOSPHORYLATION; EPITOPE MAPPING; HUMAN; HUMAN CELL; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 14844355875     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.6.3306     Document Type: Article

References (48)

1. Zhang, Y., M. Doefler, T. C. Lee, B. Guillemin, and W. N. Rom. 1993. Mechanisms of stimulation of interleukin-1β and tumor necrosis factor-α by Mycobacterium tuberculosis components. J. Clin. Invest. 91:2076.
2. Friedland, J. S., R. Shattock, D. G. Remake, and E. Griffin. 1993. Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells. Clin. Exp. Immunol. 91:8.
3. Retzlaff, C., Y. Yamamoto, P. S. Hoffman, H. Friedman, and T. W. Klein. 1994. Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures. Infect. Immun. 6:5689.
4. Peetermans, W. E., C. J. I. Raats, R. van Furth and J. A. M. Langermans. 1995. Mycobacterial 65-kilodalton heat shock protein induces tumor necrosis factor α, interleukin 6, reactive nitrogen intermediates and toxoplasmatatic activity in murine peritoneal macrophages. Infect. Immun. 63:3454.
5. Cho, B. K. D. Palliser, E. Guillen, J. J. Wisniewski, R. A. R. A. Young, J. Chen, and H. N. Eisen. 2001. A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins. Immunity 12:263.
6. Vabulas, R. M., P. Ahmad-Nejad, S. Ghose, C. J. Kirschning, R. D. Issels, and H. Wagner. 2002, HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J. Biol. Chem. 277:15107.
7. Wang, Y., C. G. Kelly, M. Singh, E. G. McGowan, A. S. Carrara, L. A. Bergmeier and T. Lehner. 2002. Stimulation of Th1-polarizing cytokines, CC chemokines, maturation of dendritic cells, and adjuvant function by the peptide binding fragment of heat shock protein 70. J. Immunol. 169:2422.
8. Lehner, T., L. A. Bergmeier, Y. Wang, L. Tao, M. Singh, R. Spallek, R., and van der Zee. 2001. Heat shock protein generates β-chemokines which function as innate adjuvants enhancing adaptive immunity. Eur. J. Immunol. 30:594.
9. Wang, Y., C. G. Kelly, J. K. Karttunen, T. Whittall, P. J. Lehner, L. Duncan, P. MacAry, J. S. Younson, M. Singh, W. Oehlmann, et al. 2001. CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines. Immunity 1:971.
10. Lussow, A. R., C. Barrios, J. van Embden, R. van der Zee, A. S. Verdini, A. Pessi, J. A. Louis, P.-H. Lambert, and G. D. Giudice. 1991. Mycobacterial heat-shock proteins as carrier molecules. Eur. J. Immunol. 21:2297.
11. Barrios, C., J. A. Lussow, J. van Embden, R. van der Zee, R. Rappouli, P. Costantino, J. A. Louis, P.-H. Lambert, and G. Giudice. 1992. Mycobacterial heat-shock proteins as carrier molecules. II. The use of the 70kDa mycobacterial carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guérin priming. Eur. J. Immunol. 22:1365.
12. Perraut, R., A. R. Lussow, S. Gavoille, O. Garraud, H. Matile, C. Tougne, J. van Embden, R. van der Zee, P.-H. Lambert, J. Gysin, and G. D. Giudice. 1993. Successful primate immunization with peptide conjugated to purified derivative or mycobacterial heat shock proteins in the absence of adjuvants. Clin. Exp. Immunol. 93:382.
13. Suzue, K., and R. A. Young. 1996. Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. J. Immunol. 158: 873.
14. Haiti, F. U. 1996. Molecular chaperones in cellular protein folding. Nature 381: 571.
15. Castellino, F., P. E. Boucher, K. Eichelberg, M. Mayhew, J. E. Rothman, A. N. Houghton, and R. N. Germain. 2000. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class 1 antigen presentation via two distinct processing pathway. J. Exp. Med. 191:1957.
16. Singh-Jasuja, H., R. E. M. Toes, P. Spee, C. Munz, N. Hilf, S. P. Schoenberger, P. Ricciardi-Castagnoli, J. Neefjes, H. G. Rammensee, D. Arnold-Schild, and H. Schild. 2000. Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis. J. Exp. Med. 191:1965.
17. Srivastava, P. 2002. Roles of heat shock proteins in innate and adaptive immunity. Nat. Rev. Immunol. 2:185.
18. Mazzaferro, V., J. Coppa, M. G. Carrabba, L. Rivoltini, M. Schiavo, E. Regalia, L. Mariani, T. Camerini, A. Marchiano, S. Andreola, et al. 2003. Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer. Clin. Cancer Res. 9:3235.
19. Zhu, X., X. Zhao, W. F. Burkholder, A. Gragerov, C. M. Ogata, M. E. Gottesman, and W. A. Hendrickson. 1996. Structural analysis of substrate binding by the molecular chaperone DnaK. Science 272:1606.
20. + T cell independent. J. Exp. Med. 191:403.
21. + T cells during rat listeriosis. Int. Immunol. 10:117.
22. Wendling, U., L. Paul, R. Van der Zee, B. Prakken, M. Singh, and W. Van Eden. 2000. A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue. J. Immunol. 164: 2711.
23. Kol, A., A. H. Lichtman, R. W. Finberg, P. Libby, and E. A. Kurt-Jones. 2000. Cutting Edge: Heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells. J. Immunol. 164:13.
24. Ohashi, K., V. Burkart, S. Flohë, and H. Kolb. 2000. Cutting Edge: Heat shock proteins 60 is a endogenous ligand of the Toll-like receptor-4 complex. J. Immunol. 164:558.
25. Asea, A., S. K. Kraeft, E. A. Kurt-Jones, M. A. Stevenson, L. B. Chen, R. W. Finberg, G. C. Koo, and S. K. Calderwood. 2000. HSP70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine. Nat. Med. 6:435.
26. Becker, T., F.-U. Hartl, and F. Wieland. 2002. CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J. Cell Biol. 158:1277.
27. Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of IL-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
28. Caux, C., C. Massacrier, B. Vanbervliet, B. Dubois, C. van Kooten, I. Durand, and J. Banchereau. 1994. Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180:1263.
29. Grewal, I. S., and R. A. Flavell. 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16:111.
30. Lehner, T., Y. Wang, and C. Kelly. 2003. Heat shock protein receptors, functions and their effect on monocytes and dendritic cells. In: Heat Shock Proteins & Inflammation. W. van Eden, and D. B. Young, eds. Dekker, Basel, Switzerland, p. 193.
31. Lazarevic, V., A. J. Myers, C. A. Scanga, and J. L. Flynn. 2003. CD40, but not CD40L, is required for the optimal priming of T cell and control of aerosol M. tuberculosis infection. Immunity 19:823.
32. Millar, D. G., K. M. Garza, B. Odermatt, A. R. Elford, N. Ono, Z. Li, and P. S. Ohashi. 2003. HSP70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo. Nat. Med. 9:1469.
33. Steinman, R. M., D. Hawiger, and M. C. Nussenzweig. 2003. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21:685.
34. Singh, M., A. B. Andersen, J. E. G. McCarthy, M. Rhode, H. Schutte, E. Sanders, and K. N. Timmis. 1992. The Mycobacterium tuberculosis 38-kDa antigen: overproduction in Escherichia coli, purification and expression. Gene 117:53.
35. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179:1109.
36. Stamenkovic, I., E. A. Clark, and B. Seed. 1989. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 8:1403.
37. Aicher, A., G. L. Shu, D. Magaletti, T. Mulvania, A. Craxton, and E. A. Clark. 1999. Differential role for p38 mitogen-activated protein kinase in regulating CD40-induced gene expression in dendritic cells and B cells. J. Immunol. 163:5786.
38. + T cell memory response. J. Immunol. 172:6047.
39. MacAry, P. A., B. Javid, R. A. Floto, K. G. C. Smith, W. Oehlmann, M. Singh, and P. J. Lehner. 2004. HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation. Immunity 20:95.
40. Pearson, L. L., B. E. Castle, and M. R. Kehry. 2001. CD40-mediated signalling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signalling pathways. Int. Immunol. 13:273.
41. Messmer, D., B. Messmer, and N. Chiorazzi. 2003. The global transcriptional maturation program and stimuli-specific gene expression profiles of human myeloid dendritic cells. Int. Immunol. 15:491.
42. Medzhitov, R. 2001. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:135.
43. Ritter, U., A. Meissner, J. Ott, and H. Korner. 2003. Analysis of the maturation process of dendritic cells deficient for TNF and lymphotoxin-α reveals an essential role for TNF. J. Leukocyte Biol. 74:216.
44. Vabulas, R. M., P. Ahmad-Nejad, C. da Costa, T. Miethke, C. J. Kirschning, H. Hacker, and H. Wagner. 2001. Endocytosed HSP60s use Toll-like receptor 2 (TLR2) and TLR4 to activate the Toll/interleukin-1 receptor signaling pathway in innate immune cells. J. Biol. Chem. 276:31332.
45. Lipsker, D., U. Ziglan, D. Fehner, F. Proamer, H. Bausinger, P. Jeannin, J. Salamero, A. Bohbot, J.-P. Cazenave, R. Drillen, et al. 2002. Heat shock proteins 70 and 60 share common receptors which are expressed on human monocyte-derived but not epidermal dendritic cells. Eur. J. Immunol. 32:322.
46. Gao, B., and M. F. Tsan. 2003. Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor α release by murine macrophages. J. Biol. Chem. 278:174.
47. Bausinger, H., D. Lipsker, U. Ziylan, S. Manie, J. P. Briand, J. P. Cazenave, S. Muller, J. F. Haeuw, C. Ravanat, H. de la Salle, and D. Hanau, D. 2003. Endotoxin-free heat-shock protein 70 fails to induce APC activation. Eur. J. Immunol. 32:3708.
48. Bogers, W. M. J. M., L. A. Bergmeier, J. Ma, H. Oostermeijer, Y. Wang, C. G. Kelly, P. ten Haaft, M. Singh, J. L. Heeney, and T. Lehner. 2004. A novel HIV-CCR5 receptor vaccine strategy in the control of mucosal SIV/HIV infection. AIDS 18:25.