Vaccination with a potent DNA vaccine targeting B-cell epitopes of hGRP induces prophylactic and therapeutic antitumor activity in vivo

Gene Therapy

Volumn 17, Issue 4, 2010, Pages 459-468

  Yong, Lu ^a,c   Huiyong, Zhang ^a,b   Jing, Hou ^a   Huaqian, Wang ^a   Xiangbing, Hu ^a   Yanjun, Ma ^a   Xiaoyu, Ge ^a   Li, Huang ^a   Yanan, Yang ^a   Rongyue, Cao ^a   Hao, Fan ^c   Jingjing, Liu ^a   Jie, Wu ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

^c Shanghai Yijiu Biomedical Cooperation Ltd   (China)

Author keywords

Gastrin releasing peptide; Immunotherapy; Neutralizing antibody; Prostate carcinoma

Indexed keywords

BOMBESIN; DNA VACCINE; EPITOPE; GASTRIN RELEASING PEPTIDE; HEAT SHOCK PROTEIN 65; HEAT SHOCK PROTEIN 70;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANTINEOPLASTIC ACTIVITY; ARTICLE; B LYMPHOCYTE; CANCER CELL CULTURE; CANCER GENE THERAPY; CANCER INHIBITION; CANCER SURVIVAL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENCY; DRUG TARGETING; HELPER CELL; HUMORAL IMMUNITY; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; INOCULATION; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROPHYLAXIS; PROSTATE CARCINOMA; SURVIVAL RATE; TANDEM REPEAT; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR IMMUNITY; TUMOR VOLUME;

ANIMALS; CANCER VACCINES; CARCINOMA; CELL LINE, TUMOR; CELL PROLIFERATION; EPITOPES, B-LYMPHOCYTE; GASTRIN-RELEASING PEPTIDE; HSP70 HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; MALE; MICE; PROSTATIC NEOPLASMS; RECOMBINANT FUSION PROTEINS; VACCINES, DNA;

MUS;

EID: 77950860743     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2009.165     Document Type: Article

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