Manipulating cofactor binding thermodynamics in an artificial oxygen transport protein

Biochemistry

Volumn 50, Issue 47, 2011, Pages 10254-10261

  Zhang, Lei ^a   Anderson, J L Ross ^b,d   Ahmed, Ismail ^a   Norman, Jessica A ^a   Negron, Christopher ^a,c   Mutter, Andrew C ^a   Dutton, P Leslie ^b   Koder, Ronald L ^a  

^a CITY COLLEGE OF NEW YORK   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL PROTEINS; BINDING EVENTS; BINDING MODELS; COFACTOR BINDING; CONFORMATIONAL CHANGE; CONFORMATIONAL STATE; CYTOGLOBIN; DISTAL HISTIDINE; ENCOUNTER COMPLEX; GLUTAMATE SIDE CHAIN; HEME BINDING; HISTIDINE RESIDUES; MUTATIONAL ANALYSIS; NEUROGLOBIN; OXIDIZED STATE; OXYGEN TRANSPORT; REDUCED-STATE; SIDE-CHAINS;

AMINO ACIDS; BINDING ENERGY; OXYGEN; PORPHYRINS; SURGICAL EQUIPMENT; THERMODYNAMICS;

PROTEINS;

ALANINE; CARRIER PROTEIN; CYTOGLOBIN; GLUTAMIC ACID; HEME; HISTIDINE; HP7 PROTEIN; NEUROGLOBIN; UNCLASSIFIED DRUG;

ABSORPTION; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; MOLECULAR MECHANICS; MUTATIONAL ANALYSIS; OXIDATION; PHOTOLYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; THERMODYNAMICS;

AMINO ACID SEQUENCE; BASE SEQUENCE; GENES, SYNTHETIC; HEME; HEMEPROTEINS; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; OXYGEN; PROTEIN BINDING; PROTEIN ENGINEERING; THERMODYNAMICS;

EID: 81855199923     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201242a     Document Type: Article

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