Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis

Journal of Neuropathology and Experimental Neurology

Volumn 70, Issue 12, 2011, Pages 1089-1096

  Koch, Sabine ^a   Molchanova, Svetlana M ^a   Wright, Ann K ^b   Edwards, Andrew ^b   Cooper, Jonathan D ^c   Taira, Tomi ^a   Gillingwater, Thomas H ^b   Tyynelä, Jaana ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cathepsin D; Electron microscopy; Electrophysiology; Hippocampus; Synapse; Synaptic vesicle

Indexed keywords

CATHEPSIN D;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DISEASE COURSE; EPILEPSY; EVOKED RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; MINIATURE EXCITATORY POSTSYNAPTIC CURRENT; MOUSE; NERVE DEGENERATION; NERVE FUNCTION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; THALAMUS;

ANIMALS; CA1 REGION, HIPPOCAMPAL; CATHEPSIN D; DISEASE MODELS, ANIMAL; EXCITATORY POSTSYNAPTIC POTENTIALS; MICE; MICE, KNOCKOUT; MINIATURE POSTSYNAPTIC POTENTIALS; NEURONAL CEROID-LIPOFUSCINOSES; NEURONS; SYNAPSES; SYNAPTIC VESICLES;

EID: 81855190913     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e318238fc28     Document Type: Article

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