Ube3a is required for experience-dependent maturation of the neocortex

Nature Neuroscience

Volumn 12, Issue 6, 2009, Pages 777-783

  Yashiro, Koji ^a,d   Riday, Thorfinn T ^a   Condon, Kathryn H ^b   Roberts, Adam C ^a,c   Bernardo, Danilo R ^a   Prakash, Rohit ^a   Weinberg, Richard J ^a,c   Ehlers, Michael D ^b   Philpot, Benjamin D ^a,c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d Urogenix Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UBE3A ENZYME; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTISM; BRAIN MATURATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME REGULATION; HAPPY PUPPET SYNDROME; LEARNING DISORDER; MOUSE; NEOCORTEX; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SENSORY DEPRIVATION; SENSORY SYSTEM; SYNAPSE; VISUAL CORTEX;

AGING; ANGELMAN SYNDROME; ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; DOMINANCE, OCULAR; LEARNING; MICE; MICE, KNOCKOUT; NEOCORTEX; NEURONAL PLASTICITY; SENSORY DEPRIVATION; UBIQUITIN-PROTEIN LIGASES; VISUAL CORTEX; VISUAL PATHWAYS; VISUAL PERCEPTION;

EID: 67349178189     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2327     Document Type: Article

References (48)

1. Clayton-Smith, J. & Laan, L. Angelman syndrome: a review of the clinical and genetic aspects. J. Med. Genet. 40, 87-95 (2003).
2. Jiang, Y.H. et al. Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron 21, 799-811 (1998).
3. Rougeulle, C., Glatt, H. & Lalande, M. The Angelman syndrome candidate gene, UBE3A/E6-AP, is imprinted in brain. Nat. Genet. 17, 14-15 (1997).
4. Schroer, R.J. et al. Autism and maternally derived aberrations of chromosome 15q. Am. J. Med. Genet. 76, 327-336 (1998).
5. Albrecht, U. et al. Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons. Nat. Genet. 17, 75-78 (1997).
6. Dindot, S.V., Antalffy, B.A., Bhattacharjee, M.B. & Beaudet, A.L. The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Hum. Mol. Genet. 17, 111-118 (2007).
7. Zoghbi, H.Y. Postnatal neurodevelopmental disorders: meeting at the synapse? Science 302, 826-830 (2003).
8. Weeber, E.J. et al. Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. J. Neurosci. 23, 2634-2644 (2003).
9. van Woerden, G.M. et al. Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of a CaMKII inhibitory phosphorylation. Nat. Neurosci. 10, 280-282 (2007).
10. Yi, J.J. & Ehlers, M.D. Ubiquitin and protein turnover in synapse function. Neuron 47, 629-632 (2005).
11. Yi, J.J. & Ehlers, M.D. Emerging roles for ubiquitin and protein degradation in neuronal function. Pharmacol. Rev. 59, 14-39 (2007).
12. Walz, N.C. & Baranek, G.T. Sensory processing patterns in persons with Angelman syndrome. Am. J. Occup. Ther. 60, 472-479 (2006).
13. Williams, C.A. et al. Angelman syndrome 2005: updated consensus for diagnostic criteria. Am. J. Med. Genet. A. 140, 413-418 (2006).
14. Hensch, T.K. Critical period plasticity in local cortical circuits. Nat. Rev. Neurosci. 6, 877-888 (2005).
15. Fagiolini, M. et al. Separable features of visual cortical plasticity revealed by N-methyld-aspartate receptor 2A signaling. Proc. Natl. Acad. Sci. USA 100, 2854-2859 (2003).
16. Gianfranceschi, L. et al. Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF. Proc. Natl. Acad. Sci. USA 100, 12486-12491 (2003).
17. Li, Y., Fitzpatrick, D. & White, L.E. The development of direction selectivity in ferret visual cortex requires early visual experience. Nat. Neurosci. 9, 676-681 (2006).
18. Wallace, W. & Bear, M.F. A morphological correlate of synaptic scaling in visual cortex. J. Neurosci. 24, 6928-6938 (2004).
19. Philpot, B.D., Sekhar, A.K., Shouval, H.Z. & Bear, M.F. Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex. Neuron 29, 157-169 (2001).
20. Kirkwood, A., Rioult, M.G. & Bear, M.F. Experience-dependent modification of synaptic plasticity in visual cortex. Nature 381, 526-528 (1996).
21. Jordan, C. & Francke, U. Ube3a expression is not altered in Mecp2 mutant mice. Hum. Mol. Genet. 15, 2210-2215 (2006).
22. Vu, T.H. & Hoffman, A.R. Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain. Nat. Genet. 17, 12-13 (1997).
23. Mullen, R.J., Buck, C.R. & Smith, A.M. Neu N, a neuronal specific nuclear protein in vertebrates. Development 116, 201-211 (1992).
24. Desai, N.S., Cudmore, R.H., Nelson, S.B. & Turrigiano, G.G. Critical periods for experience-dependent synaptic scaling in visual cortex. Nat. Neurosci. 5, 783-789 (2002).
25. Goel, A. & Lee, H.K. Persistence of experience-induced homeostatic synaptic plasticity through adulthood in superficial layers of mouse visual cortex. J. Neurosci. 27, 6692-6700 (2007).
26. Nimchinsky, E.A., Sabatini, B.L. & Svoboda, K. Structure and function of dendritic spines. Annu. Rev. Physiol. 64, 313-353 (2002).
27. Kirkwood, A., Silva, A. & Bear, M.F. Age-dependent decrease of synaptic plasticity in the neocortex of a CaMKII mutant mice. Proc. Natl. Acad. Sci. USA 94, 3380-3383 (1997).
28. Philpot, B.D., Cho, K.K. & Bear, M.F. Obligatory role of NR2A for metaplasticity in visual cortex. Neuron 53, 495-502 (2007).
29. Jiang, B., Trevino, M. & Kirkwood, A. Sequential development of long-term potentiation and depression in different layers of the mouse visual cortex. J. Neurosci. 27, 9648-9652 (2007).
30. He, H.Y., Hodos, W. & Quinlan, E.M. Visual deprivation reactivates rapid ocular dominance plasticity in adult visual cortex. J. Neurosci. 26, 2951-2955 (2006).
31. Wiesel, T.N. & Hubel, D.H. Single cell responses in striate cortex of kittens deprived of vision in one eye. J. Neurophysiol. 26, 1003-1017 (1963).
32. Gordon, J.A. & Stryker, M.P. Experience-dependent plasticity of binocular responses in the primary visual cortex of the mouse. J. Neurosci. 16, 3274-3286 (1996).
33. Crozier, R.A., Wang, Y., Liu, C.H. & Bear, M.F. Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex. Proc. Natl. Acad. Sci. USA 104, 1383-1388 (2007).
34. Xia, Z. & Storm, D.R. The role of calmodulin as a signal integrator for synaptic plasticity. Nat. Rev. Neurosci. 6, 267-276 (2005).
35. Silva, A.J., Stevens, C., Tonegawa, S. & Wang, Y. Deficient hippocampal long-term potentiation in α-calcium-calmodulin kinase II mutant mice. Science 257, 206-211 (1992).
36. Frankland, P.W., O'Brien, C., Ohno, M., Kirkwood, A. & Silva, A.J. a CaMKII-dependent plasticity in the cortex is required for permanent memory. Nature 411, 309-313 (2001).
37. Yasuda, H., Barth, A.L., Stellwagen, D. & Malenka, R.C. A developmental switch in the signaling cascades for LTP induction. Nat. Neurosci. 6, 15-16 (2003).
38. Torii, N., Kamishita, T., Otsu, Y. & Tsumoto, T. An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex. Neurosci. Lett. 185, 1-4 (1995).
39. Mulkey, R.M., Endo, S., Shenolikar, S. & Malenka, R.C. Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature 369, 486-488 (1994).
40. Fonseca, R., Vabulas, R.M., Hartl, F.U., Bonhoeffer, T. & Nagerl, U.V. A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP. Neuron 52, 239-245 (2006).
41. Colledge, M. et al. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron 40, 595-607 (2003).
42. Majdan, M. & Shatz, C.J. Effects of visual experience on activity-dependent gene regulation in cortex. Nat. Neurosci. 9, 650-659 (2006).
43. Tropea, D. et al. Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex. Nat. Neurosci. 9, 660-668 (2006).
44. Heynen, A.J. et al. Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation. Nat. Neurosci. 6, 854-862 (2003).
45. Van Splunder, J., Stilma, J.S. & Evenhuis, H.M. Visual performance in specific syndromes associated with intellectual disability. Eur. J. Ophthalmol. 13, 566-574 (2003).
46. Thompson, D.A., Kriss, A., Cottrell, S. & Taylor, D. Visual evoked potential evidence of albino-like chiasmal misrouting in a patient with Angelman syndrome with no ocular features of albinism. Dev. Med. Child Neurol. 41, 633-638 (1999).
47. Jay, V., Becker, L.E., Chan, F.W. & Perry, T.L., Sr. Puppet-like syndrome of Angelman: a pathologic and neurochemical study. Neurology 41, 416-422 (1991).
48. Gatenby, J. & Beams, H. Microscopist's Vade-Mecum 11th edn. (J. & A. Churchill, London, 1950).