Mechanism of HIV reverse transcriptase inhibition by zinc: Formation of a highly stable enzyme-(primer-template) complex with profoundly diminished catalytic activity

Journal of Biological Chemistry

Volumn 286, Issue 47, 2011, Pages 40433-40442

  Fenstermacher, Katherine J ^a   DeStefano, Jeffrey J ^a  

^a Bldg 142   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AVERAGE NUMBERS; BINDING EVENTS; HIV REVERSE TRANSCRIPTASE; PROCESSIVITY; REVERSE TRANSCRIPTION; RNASE H;

CALCIUM; CATALYST ACTIVITY; ENZYME INHIBITION; MANGANESE; MANGANESE COMPOUNDS; NUCLEOTIDES; OPTIMIZATION; TRANSCRIPTION;

ZINC;

CALCIUM ION; MAGNESIUM ION; MANGANESE; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; ZINC ION;

ARTICLE; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION;

AVIAN MYELOBLASTOSIS VIRUS; BIOCATALYSIS; CALCIUM; DEOXYRIBONUCLEOTIDES; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME STABILITY; HIV REVERSE TRANSCRIPTASE; HIV-1; KINETICS; MAGNESIUM; MOLONEY MURINE LEUKEMIA VIRUS; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS; RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS; TEMPLATES, GENETIC; VIRUS REPLICATION; ZINC;

EID: 81755186900     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.289850     Document Type: Article

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