Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture

PLoS Pathogens

Volumn 6, Issue 11, 2010, Pages

  te Velthuis, Aartjan J W ^a   van den Worml, Sjoerd H E ^a   Sims, Amy C ^b   Baric, Ralph S ^b   Snijder, Eric J ^a   van Hemert, Martijn J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRITHIONE; RNA POLYMERASE; VIRUS PROTEIN; VIRUS RNA; ZINC ION; IONOPHORE; MESSENGER RNA; RNA DIRECTED RNA POLYMERASE; ZINC DERIVATIVE;

ARTERIVIRUS; ARTICLE; CELL CULTURE; CELL MEMBRANE; CHELATION; CORONAVIRUS; CYTOTOXICITY; DRUG ACTIVITY; ENZYME ANALYSIS; EQUINE VIRAL ARTERITIS VIRUS; ESCHERICHIA COLI; GENE EXPRESSION; IN VITRO STUDY; INHIBITION KINETICS; LOW DRUG DOSE; NONHUMAN; REPORTER GENE; RNA ISOLATION; RNA SYNTHESIS; SARS CORONAVIRUS; VIRUS REPLICATION; VIRUS TRANSCRIPTION; ANIMAL; ARTERIVIRUS INFECTION; CERCOPITHECUS; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GEL MOBILITY SHIFT ASSAY; GENETICS; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEVERE ACUTE RESPIRATORY SYNDROME; VERO CELL; VIROLOGY; WESTERN BLOTTING;

ARTERIVIRUS; CORONAVIRUS; EQUINE ARTERITIS VIRUS; ORTHOMYXOVIRIDAE; POLIOVIRUS; RNA VIRUSES; SARS CORONAVIRUS;

ANIMALS; ARTERIVIRUS; ARTERIVIRUS INFECTIONS; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ESCHERICHIA COLI; IONOPHORES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA REPLICASE; RNA, MESSENGER; RNA, VIRAL; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VERO CELLS; VIRUS REPLICATION; ZINC COMPOUNDS;

EID: 79251492015     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001176     Document Type: Article

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