메뉴 건너뛰기




Volumn 6, Issue 4, 2011, Pages 403-411

Investigation into the cancer protective effect of flaxseed in Tg.NK (MMTV/c-neu) mice, a murine mammary tumor model

Author keywords

Flaxseed; Hepatic enzymes; Lignans; Mammary tumorigenesis; Tg.NK mice

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; GLUTATHIONE TRANSFERASE;

EID: 81755184342     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-011-0214-1     Document Type: Article
Times cited : (6)

References (44)
  • 1
    • 0028849729 scopus 로고
    • Phytoestrogens: Epidemiology and a possible role in cancer protection
    • 8593855 10.1289/ehp.95103s7103 1:CAS:528:DyaK28XlvFeitA%3D%3D
    • H Adlercreutz 1995 Phytoestrogens: epidemiology and a possible role in cancer protection Environ Health Perspect 103 7 103 112 8593855 10.1289/ehp.95103s7103 1:CAS:528:DyaK28XlvFeitA%3D%3D
    • (1995) Environ Health Perspect , vol.103 , Issue.7 , pp. 103-112
    • Adlercreutz, H.1
  • 2
    • 0038386061 scopus 로고    scopus 로고
    • Phytoestrogens and breast cancer
    • DOI 10.1016/S0960-0760(02)00273-X
    • H Adlercreutz 2002 Phytoestrogens and breast cancer J Steroid Biochem Mol Biol 83 113 118 12650707 10.1016/S0960-0760(02)00273-X 1:CAS:528: DC%2BD3sXitFahsrc%3D (Pubitemid 37040647)
    • (2002) Journal of Steroid Biochemistry and Molecular Biology , vol.83 , Issue.1-5 , pp. 113-118
    • Adlercreutz, H.1
  • 3
    • 0020414806 scopus 로고
    • Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer
    • 6128595 10.1016/S0140-6736(82)91507-0 1:CAS:528:DyaL3sXhvFKrtbw%3D
    • H Adlercreutz T Fotsis R Heikkinen JT Dwyer M Woods BR Goldin SL Gorbach 1982 Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer Lancet 2 1295 1299 6128595 10.1016/S0140-6736(82)91507-0 1:CAS:528: DyaL3sXhvFKrtbw%3D
    • (1982) Lancet , vol.2 , pp. 1295-1299
    • Adlercreutz, H.1    Fotsis, T.2    Heikkinen, R.3    Dwyer, J.T.4    Woods, M.5    Goldin, B.R.6    Gorbach, S.L.7
  • 6
    • 0034733866 scopus 로고    scopus 로고
    • Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat
    • DOI 10.1016/S0304-3835(00)00401-8, PII S0304383500004018
    • V Breinholt ST Lauridsen B Daneshvar J Jakobsen 2000 Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat Cancer Lett 154 201 210 10806309 10.1016/S0304-3835(00)00401-8 1:CAS:528:DC%2BD3cXjtVCjt7c%3D (Pubitemid 30259228)
    • (2000) Cancer Letters , vol.154 , Issue.2 , pp. 201-210
    • Breinholt, V.1    Lauridsen, S.T.2    Daneshvar, B.3    Jakobsen, J.4
  • 7
    • 0029116150 scopus 로고
    • Xenoestrogens alter Mammary-Gland differentiation and cell-proliferation in the rat
    • 7588483 1:CAS:528:DyaK2MXnslWjtbY%3D
    • NM Brown CA Lamartiniere 1995 Xenoestrogens alter Mammary-Gland differentiation and cell-proliferation in the rat Environ Health Perspect 103 708 713 7588483 1:CAS:528:DyaK2MXnslWjtbY%3D
    • (1995) Environ Health Perspect , vol.103 , pp. 708-713
    • Brown, N.M.1    Lamartiniere, C.A.2
  • 8
    • 0028106482 scopus 로고
    • Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
    • DOI 10.1016/0006-2952(94)90363-8
    • MD Burke S Thompson RJ Weaver CR Wolf RT Mayer 1994 Cytochrome-P450 Specificities of Alkoxyresorufin O-Dealkylation in Human and Rat-Liver Bioche Pharmacol 48 923 936 10.1016/0006-2952(94)90363-8 1:CAS:528:DyaK2cXmvFGktLg%3D (Pubitemid 24285170)
    • (1994) Biochemical Pharmacology , vol.48 , Issue.5 , pp. 923-936
    • Danny Burke, M.1    Thompson, S.2    Weaver, R.J.3    Roland Wolf, C.4    Mayers, R.T.5
  • 9
    • 9344238812 scopus 로고    scopus 로고
    • Dietary flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen-dependent human breast cancer (MCF-7) in nude mice
    • DOI 10.1158/1078-0432.CCR-04-1130
    • J Chen E Hui T Ip LU Thompson 2004 Dietary flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen-dependent human breast cancer (mcf-7) in nude mice Clin Cancer Res 10 7703 7711 15570004 10.1158/1078-0432.CCR-04-1130 1:CAS:528:DC%2BD2cXhtVanur3I (Pubitemid 39557535)
    • (2004) Clinical Cancer Research , vol.10 , Issue.22 , pp. 7703-7711
    • Chen, J.1    Hui, E.2    Ip, T.3    Thompson, L.U.4
  • 10
    • 34548443813 scopus 로고    scopus 로고
    • Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen
    • DOI 10.3181/0702-RM-36
    • J Chen KA Power J Mann A Cheng LU Thompson 2007 Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen Exp Biol Med (Maywood) 232 1071 1080 10.3181/0702-RM-36 1:CAS:528:DC%2BD2sXhtVSnsbjP (Pubitemid 47358190)
    • (2007) Experimental Biology and Medicine , vol.232 , Issue.8 , pp. 1071-1080
    • Chen, J.1    Power, K.A.2    Mann, J.3    Cheng, A.4    Thompson, L.U.5
  • 11
    • 0141513737 scopus 로고    scopus 로고
    • Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis
    • J Chen KP Tan WE Ward LU Thompson 2003 Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis Exp Biol Med (Maywood) 228 951 958 1:CAS:528:DC%2BD3sXntlaktrg%3D (Pubitemid 37163248)
    • (2003) Experimental Biology and Medicine , vol.228 , Issue.8 , pp. 951-958
    • Chen, J.1    Tan, K.P.2    Ward, W.E.3    Thompson, L.U.4
  • 12
    • 0035978461 scopus 로고    scopus 로고
    • The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats
    • DOI 10.1016/S0378-4274(01)00348-4, PII S0378427401003484
    • M Dalgaard C Nellemann HR Lam IK Sorensen O Ladefoged 2001 The acute effects of mono (2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats Toxicol Lett 122 69 79 11397558 10.1016/S0378-4274(01)00348-4 1:CAS:528:DC%2BD3MXktVKksrY%3D (Pubitemid 32524059)
    • (2001) Toxicology Letters , vol.122 , Issue.1 , pp. 69-79
    • Dalgaard, M.1    Nellemann, C.2    Lam, H.R.3    Sorensen, I.K.4    Ladefoged, O.5
  • 14
    • 33847796827 scopus 로고    scopus 로고
    • Timing of dietary estrogenic exposures and breast cancer risk
    • DOI 10.1196/annals.1386.039, Estrogens and Human Diseases
    • AS de L Hilakivi-Clarke 2006 Timing of dietary estrogenic exposures and breast cancer risk Ann NY Acad Sci 1089 14 35 10.1196/annals.1386.039 (Pubitemid 47092094)
    • (2006) Annals of the New York Academy of Sciences , vol.1089 , pp. 14-35
    • De Assis, S.1    Hilakivi-Clarke, L.2
  • 15
  • 16
    • 0016811999 scopus 로고
    • Glutathione S-transferase in formation of cyanide from organic thiocyanates and as an organic nitrate reductase
    • 1170853 10.1016/0006-291X(75)90349-6 1:CAS:528:DyaE2MXkt1ChtL0%3D
    • WH Habig JH Keen WB Jakoby 1975 Glutathione S-transferase in formation of cyanide from organic thiocyanates and as an organic nitrate reductase Biochem Biophys Res Commun 64 501 506 1170853 10.1016/0006-291X(75)90349-6 1:CAS:528:DyaE2MXkt1ChtL0%3D
    • (1975) Biochem Biophys Res Commun , vol.64 , pp. 501-506
    • Habig, W.H.1    Keen, J.H.2    Jakoby, W.B.3
  • 17
    • 34547558889 scopus 로고    scopus 로고
    • Nutritional modulation of terminal end buds: Its relevance to breast cancer prevention
    • DOI 10.2174/156800907781386641
    • L Hilakivi-Clarke 2007 Nutritional modulation of terminal end buds: its relevance to breast cancer prevention Curr Cancer Drug Targets 7 465 474 17691906 10.2174/156800907781386641 1:CAS:528:DC%2BD2sXhtVKqsLjK (Pubitemid 47196206)
    • (2007) Current Cancer Drug Targets , vol.7 , Issue.5 , pp. 465-474
    • Hilakivi-Clarke, L.1
  • 18
    • 34548852835 scopus 로고    scopus 로고
    • Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro
    • DOI 10.1016/j.fct.2007.05.017, PII S0278691507001809
    • C Hu YV Yuan DD Kitts 2007 Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro Food Chem Toxicol 45 2219 2227 17624649 10.1016/j.fct.2007.05.017 1:CAS:528:DC%2BD2sXhtFWit7jP (Pubitemid 47451575)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.11 , pp. 2219-2227
    • Hu, C.1    Yuan, Y.V.2    Kitts, D.D.3
  • 19
    • 0034000680 scopus 로고    scopus 로고
    • Low alpha linolenic acid content of adipose breast tissue is associated with increased risk of breast cancer
    • Klein V, Chajès V, Germain E, Schulgen G, Pinault M, Malvy D, Lefrancq T, Fignon A, Floch O Le, Lhuillery C, Bougnoux P (2000) Low alpha linolenic acid content of adipose breast tissue is associated with increased risk of breast cancer. Eur J Cancer 36:335-340
    • (2000) Eur J Cancer , vol.36 , pp. 335-340
    • Klein V, C.1
  • 20
    • 0030811507 scopus 로고    scopus 로고
    • Dietary phytoestrogens
    • DOI 10.1146/annurev.nutr.17.1.353
    • MS Kurzer X Xu 1997 Dietary phytoestrogens Annual Rev Nutr 17 353 381 10.1146/annurev.nutr.17.1.353 1:CAS:528:DyaK2sXkvFGmtL0%3D (Pubitemid 27328805)
    • (1997) Annual Review of Nutrition , vol.17 , pp. 353-381
    • Kurzer, M.S.1    Xu, X.2
  • 21
    • 0003122802 scopus 로고
    • Preparation and characterization of microsomal fractions for studies on xenobiotic metabolism
    • K. Snell B. Mullock (eds). IRL Press Oxford, England
    • Lake BG (1987) Preparation and characterization of microsomal fractions for studies on xenobiotic metabolism. In: Snell K, Mullock B (eds) Biochemical toxicology: a practical approach. IRL Press, Oxford, England, pp 183-215
    • (1987) Biochemical Toxicology: A Practical Approach , pp. 183-215
    • Lake, B.G.1
  • 23
    • 34247095671 scopus 로고    scopus 로고
    • Modulation of mammary tumor development in Tg.NK (MMTV/c-neu) mice by dietary fatty acids and life stage-specific exposure to phytoestrogens
    • DOI 10.1016/j.reprotox.2006.12.001, PII S0890623806002802
    • M Luijten A Verhoef JAMA Dormans RB Beems HWJM Cremers NJD Nagelkerke H Adlercreutz JL Penalvo AH Piersma 2007 Modulation of mammary tumor development in Tg.NK (MMTV/c-neu) mice by dietary fatty acids and life stage-specific exposure to phytoestrogens Reprod Toxicol 23 407 413 17229545 10.1016/j.reprotox.2006.12.001 1:CAS:528:DC%2BD2sXksFegtbg%3D (Pubitemid 46602930)
    • (2007) Reproductive Toxicology , vol.23 , Issue.3 , pp. 407-413
    • Luijten, M.1    Verhoef, A.2    Dormans, J.A.M.A.3    Beems, R.B.4    Cremers, H.W.J.M.5    Nagelkerke, N.J.D.6    Adlercreutz, H.7    Penalvo, J.L.8    Piersma, A.H.9
  • 25
    • 0023713558 scopus 로고
    • Single-Step Induction of Mammary Adenocarcinoma in Transgenic Mice Bearing the Activated C-Neu Oncogene
    • 2898299 10.1016/0092-8674(88)90184-5 1:CAS:528:DyaL1cXkvVOgt7c%3D
    • WJ Muller E Sinn PK Pattengale R Wallace P Leder 1988 Single-Step Induction of Mammary Adenocarcinoma in Transgenic Mice Bearing the Activated C-Neu Oncogene Cell 54 105 115 2898299 10.1016/0092-8674(88)90184-5 1:CAS:528:DyaL1cXkvVOgt7c%3D
    • (1988) Cell , vol.54 , pp. 105-115
    • Muller, W.J.1    Sinn, E.2    Pattengale, P.K.3    Wallace, R.4    Leder, P.5
  • 26
    • 0141706504 scopus 로고    scopus 로고
    • Studies on the metabolism of the plant lignans secoisolariciresinol and matairesinol
    • 14518962 10.1021/jf030263n 1:CAS:528:DC%2BD3sXmvVGhu7w%3D
    • HB Niemeyer DM Honig SE Kulling M Metzler 2003 Studies on the metabolism of the plant lignans secoisolariciresinol and matairesinol J Agric Food Chem 51 6317 6325 14518962 10.1021/jf030263n 1:CAS:528:DC%2BD3sXmvVGhu7w%3D
    • (2003) J Agric Food Chem , vol.51 , pp. 6317-6325
    • Niemeyer, H.B.1    Honig, D.M.2    Kulling, S.E.3    Metzler, M.4
  • 28
    • 70449125870 scopus 로고    scopus 로고
    • The effect of oral lipids and circulating lipoproteins on the metabolism of drugs
    • 10.1517/17425250903176439 1:CAS:528:DC%2BD1MXhtlersrvN
    • PJ Patel DR Brocks 2009 The effect of oral lipids and circulating lipoproteins on the metabolism of drugs Expet Opin Drug Metabol Toxicol 5 1385 1398 10.1517/17425250903176439 1:CAS:528:DC%2BD1MXhtlersrvN
    • (2009) Expet Opin Drug Metabol Toxicol , vol.5 , pp. 1385-1398
    • Patel, P.J.1    Brocks, D.R.2
  • 29
    • 3042606362 scopus 로고    scopus 로고
    • Plant lignans in soy-based health supplements
    • 15212459 10.1021/jf0497509 1:CAS:528:DC%2BD2cXksVKhtrY%3D
    • JL Penalvo SM Heinonen T Nurmi T Deyama S Nishibe H Adlercreutz 2004 Plant lignans in soy-based health supplements J Agric Food Chem 52 4133 4138 15212459 10.1021/jf0497509 1:CAS:528:DC%2BD2cXksVKhtrY%3D
    • (2004) J Agric Food Chem , vol.52 , pp. 4133-4138
    • Penalvo, J.L.1    Heinonen, S.M.2    Nurmi, T.3    Deyama, T.4    Nishibe, S.5    Adlercreutz, H.6
  • 30
    • 8444230024 scopus 로고    scopus 로고
    • Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detection
    • DOI 10.1016/j.ab.2004.05.046, PII S0003269704004853
    • JL Penalvo T Nurmi K Haajanen N Al-Maharik N Botting H Adlercreutz 2004 Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detection Anal Biochem 332 384 393 15325308 10.1016/j.ab.2004.05.046 1:CAS:528:DC%2BD2cXmvFeltbk%3D (Pubitemid 39485748)
    • (2004) Analytical Biochemistry , vol.332 , Issue.2 , pp. 384-393
    • Penalvo, J.L.1    Nurmi, T.2    Haajanen, K.3    Al-Maharik, N.4    Botting, N.5    Adlercreutz, H.6
  • 33
    • 33646920929 scopus 로고    scopus 로고
    • Plasma enterolactone and genistein and the risk of premenopausal breast cancer
    • DOI 10.1097/01.cej.0000197449.56862.75, PII 0000846920060600000007
    • R Piller J Chang-Claude J Linseisen 2006 Plasma enterolactone and genistein and the risk of premenopausal breast cancer Eur J Cancer Prev 15 225 232 16679865 10.1097/01.cej.0000197449.56862.75 1:CAS:528:DC%2BD28XntlWht7o%3D (Pubitemid 43791768)
    • (2006) European Journal of Cancer Prevention , vol.15 , Issue.3 , pp. 225-232
    • Piller, R.1    Chang-Claude, J.2    Linseisen, J.3
  • 34
    • 0030822073 scopus 로고    scopus 로고
    • Influence of diet on mammary cancer in transgenic mice bearing an oncogene expressed in mammary tissue
    • DOI 10.1023/A:1005822318256
    • GN Rao E Ney RA Herbert 1997 Influence of diet on mammary cancer in transgenic mice bearing an oncogene expressed in mammary tissue Breast Cancer Res Treat 45 149 158 9342440 10.1023/A:1005822318256 1:STN:280: DyaK1c%2FgtFOltQ%3D%3D (Pubitemid 27399963)
    • (1997) Breast Cancer Research and Treatment , vol.45 , Issue.2 , pp. 149-158
    • Rao, G.N.1    Ney, E.2    Herbert, R.A.3
  • 35
    • 0022499383 scopus 로고
    • Adaptation of the bicinchoninic acid protein assay for use with microtiter plates and sucrose gradient fractions
    • MG Redinbaugh RB Turley 1986 Adaptation of the bicinchoninic acid protein assay for use with microtiter plates and sucrose gradient fractions Anal Biochem 153 267 271 3706710 10.1016/0003-2697(86)90091-6 1:CAS:528: DyaL28Xht1Gqt7w%3D (Pubitemid 16055104)
    • (1986) Analytical Biochemistry , vol.153 , Issue.2 , pp. 267-271
    • Redinbaugh, M.G.1    Turley, R.B.2
  • 36
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • DJ Slamon GM Clark SG Wong WJ Levin A Ullrich WL McGuire 1987 Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene Science 235 177 182 3798106 10.1126/science.3798106 1:CAS:528:DyaL2sXhtVSht7s%3D (Pubitemid 17231334)
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 37
    • 60849133927 scopus 로고    scopus 로고
    • Comparative study on the nuclear hormone receptor activity of various phytochemicals and their metabolites by reporter gene assays using Chinese hamster ovary cells
    • 19182375 10.1248/bpb.32.195 1:CAS:528:DC%2BD1MXmsVWrsrk%3D
    • S Takeuchi T Takahashi Y Sawada M Iida T Matsuda H Kojima 2009 Comparative study on the nuclear hormone receptor activity of various phytochemicals and their metabolites by reporter gene assays using Chinese hamster ovary cells Biol Pharm Bull 32 195 202 19182375 10.1248/bpb.32.195 1:CAS:528:DC%2BD1MXmsVWrsrk%3D
    • (2009) Biol Pharm Bull , vol.32 , pp. 195-202
    • Takeuchi, S.1    Takahashi, T.2    Sawada, Y.3    Iida, M.4    Matsuda, T.5    Kojima, H.6
  • 38
    • 0742270542 scopus 로고    scopus 로고
    • Mammary Gland Morphogenesis Is Enhanced by Exposure to Flaxseed or Its Major Lignan during Suckling in Rats
    • KP Tan J Chen WE Ward LU Thompson 2004 Mammary gland morphogenesis is enhanced by exposure to flaxseed or its major lignan during suckling in rats Exp Biol Med (Maywood) 229 147 157 1:CAS:528:DC%2BD2cXpvFSrtg%3D%3D (Pubitemid 38146558)
    • (2004) Experimental Biology and Medicine , vol.229 , Issue.2 , pp. 147-157
    • Tan, K.P.1    Chen, J.2    Ward, W.E.3    Thompson, L.U.4
  • 39
    • 27644442443 scopus 로고    scopus 로고
    • Influence of Prevastein®, an isoflavone-rich soy product, on mammary gland development and tumorigenesis in Tg.NK (MMTV/c-neu) mice
    • DOI 10.1207/s15327914nc5202-8
    • AR Thomsen A Mortensen VM Breinholt RH Lindecrona JL Penalvo IK Sorensen 2005 Influence of Prevastein, an isoflavone-rich soy product, on mammary gland development and tumorigenesis in Tg.NK (MMTV/c-neu) mice Nutr Cancer 52 176 188 16201849 10.1207/s15327914nc5202-8 1:CAS:528:DC%2BD2MXht1egtLrN (Pubitemid 41579760)
    • (2005) Nutrition and Cancer , vol.52 , Issue.2 , pp. 176-188
    • Thomsen, A.R.1    Mortensen, A.2    Breinholt, V.M.3    Lindecrona, R.H.4    Penalvo, J.L.5    Sorensen, I.K.6
  • 40
    • 0032824053 scopus 로고    scopus 로고
    • Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures
    • DOI 10.1093/carcin/20.9.1831
    • JC Tou LU Thompson 1999 Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures Carcinogenesis 20 1831 1835 10469631 10.1093/carcin/20.9.1831 1:CAS:528:DyaK1MXlvFWqtrg%3D (Pubitemid 29410565)
    • (1999) Carcinogenesis , vol.20 , Issue.9 , pp. 1831-1835
    • Tou, J.C.L.1    Thompson, L.U.2
  • 43
    • 0032998551 scopus 로고    scopus 로고
    • Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes
    • H Yamazaki T Shimada 1999 Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human CYP450 enzymes Xenobiotica 29 3 231 241 10219964 10.1080/004982599238632 1:CAS:528:DyaK1MXitleitL0%3D (Pubitemid 29140093)
    • (1999) Xenobiotica , vol.29 , Issue.3 , pp. 231-241
    • Yamazaki, H.1    Shimada, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.