Metabonomic phenotyping reveals an embryotoxicity of deca-brominated diphenyl ether in mice

Chemical Research in Toxicology

Volumn 24, Issue 11, 2011, Pages 1976-1983

  Chi, Yi ^a   Xia, Hongfei ^d   Su, Mingming ^c   Song, Peipei ^d   Qi, Xin ^a   Cui, Yi ^d   Cao, Yu ^a   Chen, Tianlu ^a   Qiu, Yunping ^e   Zhao, Aihua ^a   Ma, Xu ^d   Zheng, Xiaoying ^b   Jia, Wei ^e  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c David H Murdock Research Institute   (United States)

^d NATIONAL RESEARCH INSTITUTE FOR FAMILY PLANNING   (China)

^e UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (OCTACECENOYL)GLYCEROL; 2 (OCTADECENOYL)GLYCEROL; ARACHIDONIC ACID; CHOLESTEROL; DOCOSAHEXAENOIC ACID; FUMARIC ACID; GLUCONIC ACID; GLYCEROL; GLYCEROL 1 STEARATE; GLYCEROL DERIVATIVE; GLYCEROPHOSPHATE; LINOLEIC ACID; LIOTHYRONINE; LIPID EMULSION; MALIC ACID; OLEIC ACID; PALMITELAIDIC ACID; PALMITIC ACID; POLYBROMINATED DIPHENYL ETHER; STEARIC ACID; THYROXINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FETUS; FETUS MALFORMATION; GAS CHROMATOGRAPHY; GESTATION PERIOD; INTRAUTERINE GROWTH RETARDATION; LIPID METABOLISM; MATERNAL SERUM; METABOLIC DISORDER; METABOLITE; METABONOMIC PHENOTYPING; MOUSE; NONHUMAN; PHENOTYPE; QUANTITATIVE ANALYSIS; THYROID HORMONE METABOLISM; TIME OF FLIGHT MASS SPECTROMETRY;

ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FETAL DEVELOPMENT; FETUS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HALOGENATED DIPHENYL ETHERS; HEART; HUMANS; INTUBATION, GASTROINTESTINAL; LIPID METABOLISM; LIVER; MATERNAL EXPOSURE; METABOLOMICS; MICE; MICE, INBRED C57BL; ORGAN SIZE; PREGNANCY; TERATOGENS; THYROID HORMONES;

MUS;

EID: 81755173050     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200300v     Document Type: Article

References (50)

1. Talsness, C. E. (2008) Overview of toxicological aspects of polybrominated diphenyl ethers: A flame-retardant additive in several consumer products Environ. Res. 108, 158-167
2. Costa, L. G. and Giordano, G. (2007) Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants Neurotoxicology 28, 1047-1067 (Pubitemid 350026603)
3. Zhang, S., Bursian, S. J., Martin, P. A., Chan, H. M., Tomy, G., Palace, V. P., Mayne, G. J., and Martin, J. W. (2009) Reproductive and developmental toxicity of a pentabrominated diphenyl ether mixture, DE-71, to ranch mink (Mustela vison) and hazard assessment for wild mink in the great lakes region Toxicol. Sci. 110, 107-116
4. Yu, L. Q., Deng, J., Shi, X. J., Liu, C. S., Yu, K., and Zhou, B. S. (2010) Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae Aquat. Toxicol. 97, 226-233
5. Daubie, S., Bisson, J. F., Lalonde, R., Schroeder, H., and Rychen, G. (2011) Neurobehavioral and physiological effects of low doses of polybrominated diphenyl ether (PBDE)-99 in male adult rats Toxicol. Lett. 204, 57-63
6. Lorber, M. (2008) Exposure of Americans to polybrominated diphenyl ethers J. Exposure Sci. Environ. Epidemiol. 18, 2-19 (Pubitemid 350293659)
7. Toms, L. M. L., Sjodin, A., Harden, F., Hobson, P., Jones, R., Edenfield, E., and Mueller, J. F. (2009) Serum polybrominated diphenyl ether (PBDE) levels are higher in children (2-5 years of age) than in infants and adults Environ. Health Perspect. 117, 1461-1465
8. Frederiksen, M., Thomsen, C., Froshaug, M., Vorkamp, K., Thomsen, M., Becher, G., and Knudsen, L. E. (2010) Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort Int. J. Hyg. Environ. Health 213, 233-242
9. Warren, G. F, Sandra, G, Katherine, M. M, Stephanie, A. A, Cariton, K, Brian, S, and T, K. (2011) Human maternal and umbilical cord blood concentrations of polybrominated diphenyl ethers Chemosphere 84, 1301-1309
10. Herbstman, J. B., Sjodin, A., Kurzon, M., Lederman, S. A., Jones, R. S., Rauh, V., Needham, L. L., Tang, D., Niedzwiecki, M., Wang, R. Y., and Perera, F. (2010) Prenatal exposure to PBDEs and neurodevelopment Environ. Health Perspect. 118, 712-719
11. Morck, A., Hakk, H., Orn, U., and Klasson Wehler, E. (2003) Decabromodiphenyl ether in the rat: absorption, distribution, metabolism, and excretion Drug Metab. Dispos. 31, 900-907 (Pubitemid 36759060)
12. Costa, L. G. and Giordano, G. (2011) Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant? Neurotoxicology 32, 9-24
13. McDonald, T. A. (2002) A perspective on the potential health risks of PBDEs Chemosphere 46, 745-755 (Pubitemid 34304095)
14. Stapleton, H. M., Brazil, B., Holbrook, R. D., Mitchelmore, C. L., Benedict, R., Konstantinov, A., and Potter, D. (2006) In vivo and in vitro debromination of decabromodiphenyl ether (BDE 209) by juvenile rainbow trout and common carp Environ. Sci. Technol. 40, 4653-4658 (Pubitemid 44157201)
15. Zhou, T., Taylor, M. M., DeVito, M. J., and Crofton, K. A. (2002) Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption Toxicol. Sci. 66, 105-116 (Pubitemid 34202032)
16. Meerts, I., van Zanden, J. J., Luijks, E. A. C., van Leeuwen-Bol, I., Marsh, G., Jakobsson, E., Bergman, A., and Brouwer, A. (2000) Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro Toxicol. Sci. 56, 95-104 (Pubitemid 30441468)
17. Marsh, G., Bergman, Å., Bladh, L.-G., Gillner, M., and Jakobsson, E. (1998) Synthesis of p-hydroxybromodiphenyl ethers and binding to the thyroid hormone receptor Organohalogen Compd. 37, 305-308
18. NTP (1986) Toxicology and Carcinogenesis Studies of Decabromodiphenyl oxide (CAS No. 1163-19-5) in F344/N Rats and B6C3F1Mice (Feed studies), TR 309, National Toxicology Program, Research Triangle Park, NC.
19. Tseng, L. H., Li, M. H., Tsai, S. S., Lee, C. W., Pan, M. H., Yao, W. J., and Hsu, P. C. (2008) Developmental exposure to decabromodiphenyl ether (PBDE 209): Effects on thyroid hormone and hepatic enzyme activity in male mouse offspring Chemosphere 70, 640-647
20. Kim, T. H., Lee, Y. J., Lee, E., Kim, M. S., Kwack, S. J., Kim, K. B., Chung, K. K., Kang, T. S., Han, S. Y., Lee, J., Lee, B. M., and Kim, H. S. (2009) Effects of gestational exposure to decabromodiphenyl ether on reproductive parameters, thyroid hormone levels, and neuronal development in Sprague-Dawley rats offspring J. Toxicol. Environ. Health, Part A 72, 1296-1303
21. Staskal, D. F., Scott, L. L., Haws, L. C., Luksemburg, W. J., Birnbaum, L. S., Urban, J. D., Williams, E. S., Paustenbach, D. J., and Harris, M. A. (2008) Assessment of polybrominated diphenyl ether exposures and health risks associated with consumption of southern Mississippi catfish Environ. Sci. Technol. 42, 6755-6761
22. Man, Y. B., Lopez, B. N., Wang, H. S., Leung, A. O., Chow, K. L., and Wong, M. H. (2011) Cancer risk assessment of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in former agricultural soils of Hong Kong J. Hazard Mater. 195, 92-99
23. Yu, H. Y., Guo, Y., Bao, L. J., Qiu, Y. W., and Zeng, E. Y. (2011) Persistent halogenated compounds in two typical marine aquaculture zones of South China Mar. Pollut. Bull. 63, 572-577
24. Nicholson, J. K., Connelly, J., Lindon, J. C., and Holmes, E. (2002) Metabonomics: a platform for studying drug toxicity and gene function Nat. Rev. Drug. Discovery 1, 153-161 (Pubitemid 41646523)
25. Bao, Y. Q., Zhao, T., Wang, X. Y., Qiu, Y. P., Su, M. M., Jia, W. P., and Jia, W. (2009) Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers J. Proteome. Res 8, 1623-1630
26. Wang, X. Y., Zhao, T., Qiu, Y. P., Su, M. M., Jiang, T., Zhou, M. M., Zhao, A. H., and Jia, W. (2009) Metabonomics approach to understanding acute and chronic stress in rat models J. Proteome. Res. 8, 2511-2518
27. Xia, H. F., Chi, Y., Qi, X., Su, M. M., Cao, Y., Song, P. P., Li, X., Chen, T. L., Zhao, A. H., Zhang, Y. N., Cao, Y., Ma, X., and Jia, W. (2011) Metabolomic evaluation of di-n-butyl phthalate-induced teratogenesis in mice Metabolomics 7, 1-13
28. Fowden, A. L. (1995) Endocrine Regulation of Fetal Growth Reprod. Fertil. Develop 7, 351-363
29. Qiu, Y. P., Cai, G. X., Su, M. M., Chen, T. L., Zheng, X. J., Xu, Y., Ni, Y., Zhao, A. H., Xu, L. X., Cai, S. J., and Jia, W. (2009) Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS J. Proteome. Res 8, 4844-4850
30. Begley, P., Francis-McIntyre, S., Dunn, W. B., Broadhurst, D. I., Halsall, A., Tseng, A., Knowles, J., Goodacre, R., and Kell, D. B. (2009) Development and performance of a gas chromatography-time-of-flight mass spectrometry analysis for large-scale nontargeted metabolomic studies of human serum Anal. Chem. 81, 7038-7046
31. Wang, X. Y., Su, M. M., Qiu, Y. P., Ni, Y., Zhao, T., Zhou, M. M., Zhao, A. H., Yang, S. L., Zhao, L. P., and Jia, W. (2007) Metabolic regulatory network alterations in response to acute cold stress and ginsenoside intervention J. Proteome Res. 6, 3449-3455 (Pubitemid 47522735)
32. Wold, S. (1978) Cross-validatory estimation of the number of components in factor and principal components models Technometrics 20, 397-405
33. Norris, J. M., Kociba, R. J., Schwetz, B. A., Rose, J. Q., Humiston, C. G., Jewett, G. L., Gehring, P. J., and Mailhes, J. B. (1975) Toxicology of octabromobiphenyl and decabromodiphenyl oxide Environ. Health Perspect. 11, 153-161
34. Zoeller, R. T. and Crofton, K. M. (2000) Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals Neurotoxicology 21, 935-945 (Pubitemid 32172145)
35. Snyder, P. J. (1996) The Pituitary in Hypothyroidism, in Werner and Ingbars the Thyroid: A Fundamental and Clinical Text, 7 nth ed., pp 836-840, Lippincott-Raven Publisher, Philadelphia, PA.
36. Krebs., H. A. (1957) Control of metabolic processes Endeavour 16, 125-132
37. Brown, J., McLean, P., and Greenbaum, A. (1966) Influence of thyroxine and luteinizing hormone on some enzymes concerned with lipogenesis in adipose tissue, testis and adrenal gland Biochem. J. 101, 197-203
38. Hoch, F. (1962) Biochemical actions of thyroid hormones Physiol. Rev. 42, 605-673
39. Walters, E. and Mclean, P. (1967) Effect of thyroidenctomy on pathways of glucose metabolism in lactating rat mammary gland Biochem. J. 105, 615-623
40. Baquer, N., Cascales, M., Mclean, P., and Greenbaum, A. (1976) Effects of thyroid hormone deficiency on the distribution of hepatic metabolites and control of pathways of carbohydrate metabolism in liver and adipose tissue of the rat Eur. J. Biochem. 68, 403-413
41. Roux, C., Wolf, C., Mulliez, N., Gaoua, W., Cormier, V., Chevy, F., and Citadelle, D. (2000) Role of cholesterol in embryonic development Am. J. Clin. Nutr. 71, 1270S-1279S (Pubitemid 30230528)
42. Muenke, M., Edison, R. J., Berg, K., Remaley, A., Kelley, R., Rotimi, C., and Stevenson, R. E. (2007) Adverse birth outcome among mothers with low serum cholesterol Pediatrics 120, 723-733 (Pubitemid 47549559)
43. Hay, W. W., Jr. and Sparks, J. W. (1985) Placental, fetal, and neonatal carbohydrate metabolism Clin. Obstet. Gynecol. 28, 473-485 (Pubitemid 16244977)
44. Herrera, E. and Amusquivar, E. (2000) Lipid metabolism in the fetus and the newborn Diabetes Metab. Res. 16, 202-210 (Pubitemid 30410276)
45. Elliott, J. A. (1975) The effect of pregnancy on the control of lipolysis in fat cells isolated from human adipose tissue Eur. J. Clin. Invest. 5, 159-163
46. Metzger, B. E., P., R., Freinkel, N, and Navickas, I. A. (1980) Effects of gestational diabetes on diurnal profiles of plasma glucose, lipids, and individual amino acids Diabetes Care 3, 402-409 (Pubitemid 10000683)
47. Sivan, E., Homko, C. J., Chen, X., Reece, E. A., and Boden, G. (1999) Effect of insulin on fat metabolism during and after normal pregnancy Diabetes 48, 834-838 (Pubitemid 29153084)
48. Schinkovitz, A., Dittrich, P., and Wascher, T. C. (2001) Effects of a high-fat meal on resistance vessel reactivity and on indicators of oxidative stress in healthy volunteers Clin. Physiol. 21, 404-410
49. Scholl, T. O. and Stein, T. P. (2001) Oxidant damage to DNA and pregnancy outcome J. Matern. Fetal Med. 10, 182-185
50. Wells, P. G., McCallum, G. P., Chen, C. S., Henderson, J. T., Lee, C. J. J., Perstin, J., Preston, T. J., Wiley, M. J., and Wong, A. W. (2009) Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer Toxicol. Sci. 108, 4-18