Effects of gestational exposure to decabromodiphenyl ether on reproductive parameters, thyroid hormone levels, and neuronal development in sprague-dawley rats offspring

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 72, Issue 21-22, 2009, Pages 1296-1303

  Kim, Tae Hyung ^a   Lee, Young Jun ^a   Lee, Ena ^a   Kim, Min Sun ^a   Kwack, Seung Jun ^b   Kim, Kyu Bong ^b   Chung, Ki Kyung ^b   Kang, Tae Seok ^b   Han, Soon Young ^b   Lee, Jaewon ^a   Lee, Byung Mu ^c   Kim, Hyung Sik ^a  

^a Pusan National University   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DECABROMODIPHENYL ETHER; DIPHENYL ETHER DERIVATIVE; ESTRADIOL; TESTOSTERONE; THYROID HORMONE; THYROXINE; UNCLASSIFIED DRUG; DECABROMOBIPHENYL ETHER; FLAME RETARDANT;

ADRENAL GLAND WEIGHT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; FETUS; GENITAL SYSTEM; HIPPOCAMPUS; LOW BIRTH WEIGHT; MALE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; ORGAN WEIGHT; PERINATAL PERIOD; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; RAT; SPRAGUE DAWLEY RAT; TESTOSTERONE BLOOD LEVEL; THYROID HORMONE BLOOD LEVEL; THYROID WEIGHT; THYROXINE BLOOD LEVEL; WEIGHT GAIN; ANIMAL; BLOOD; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; DOSE RESPONSE; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY;

RATTUS;

ANIMALS; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLAME RETARDANTS; GENITALIA; HALOGENATED DIPHENYL ETHERS; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; THYROID HORMONES;

EID: 75749141326     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390903320742     Document Type: Article

References (31)

1. Akutsu, K., Tanaka, Y., and Hayakawa, K. 2006. Occurrence of polybrominated diphenyl ethers and polychlorinated biphenyls in shark liver oil supplements. Food. Addit. Contam. 23:1323-1329.
2. Bahn, A. K., Mills, J. L., Snyder, P. J., Gann, P. H., Houten, L., Bialik, O., Hollmann, L., and Utiger, R. D. 1980. Hypothyroidism in workers exposed to polybrominated biphenyls. N. Engl. J. Med. 302:31-33.
3. Bromine Science and Environmental Forum. 2006. Brominated Flame Retardants and the New EU Checmials Policy (REACH). http://www.bsef.com (accessed April 3, 2008).
4. Branchi, I., Capone, F., Alleva, E., and Costa, L. G. 2003. Polybrominated diphenyl ethers: Neurobehavioral effects following developmental exposure. Neurotoxicology 24:449-462.
5. Chao, H. R., Wang, S. L., Lee, W. J., Wang, Y. F., and Päpke, O. 2007. Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects. Environ. Int. 33:239-245.
6. Darnerud, P. O., Eriksen, G. S., Jóhannesson, T., Larsen, P. B., and Viluksela, M. 2001. Polybrominated diphenyl ethers: Occurrence, dietary exposure, and toxicology. Environ. Health Perspect. 109(suppl. 1):49-68.
7. de Wit, C. A. 2002. An overview of brominated flame retardants in the environment. Chemosphere 46:583-624.
8. Ellis-Hutchings, R. G., Cherr, G. N., Hanna, L. A., and Keen, C. L. 2006. Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development. Toxicol. Appl. Pharmacol. 215:135-145.
9. Fowles, J. R., Fairbrother, A., Baecher-Steppan, L., and Kerkvliet, N. I. 1994. Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice. Toxicology 86:49-61.
10. Hallgren, S., Sinjari, T., Håkansson, H., and Darnerud, P. O. 2001. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch. Toxicol. 75:200-208.
11. Hardy, M. L. 2002. A comparison of the properties of the major commercial PBDPO/PBDE product to those of major PBB and PCB products. Chemosphere 46:717-728.
12. Hites, R. A. 2004. Polybrominated diphenyl ethers in the environment and in people: A meta-analysis of concentrations. Environ. Sci. Technol. 38:945-956.
13. Kuriyama, S. N., Talsness, C. E., Grote, K., and Chahoud, I. 2005. Developmental exposure to low dose PBDE 99: Effects on male fertility and neurobehavior in rat offspring. Environ. Health Perspect. 113:149-154.
14. Lilienthal, H., Hack, A., Roth-Härer, A., Grande, S. W., and Talsness, C. E. 2006. Effects of developmental exposure to 2,2,4,4,5- pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats. Environ. Health Perspect. 114:194-201.
15. Lindberg, P., Sellström, U., Häggberg, L., and de Wit, C. A. 2004. Higher brominated diphenyl ethers and hexabromocyclododecane found in eggs of peregrine falcons (Falco peregrinus) breeding in Sweden. Environ. Sci. Technol. 38:93-96.
16. McDonald, T. A. 2005. Polybrominated diphenylether levels among United States residents: Daily intake and risk of harm to the developing brain and reproductive organs. Integr. Environ. Assess. Manage. 1:343-354.
17. Meerts, I. A., van Zanden, J. J., Luijks, E. A., van Leeuwen-Bol, I., Marsh, G., Jakobsson, E., Bergman, A., and Brouwer, A. 2000. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol. Sci. 56:95-104.
18. National Toxicology Program. 1986. Toxicology and carcinogenesis studies of decabromodiphenyl oxide (CAS No.1163-19-5) in F344/N rats and B6C3F1 mice (feed studies). NTP Technical Report Series No. 398. Research Triangle Park, NC: U.S. Department of Health and Human Senices, Public Health Service, National Institute of Health.
19. Norris, J. M., Kociba, R. J., Schwetz, B. A., Rose, J. Q., Humiston, C. G., Jewett, G. L., Gehring P. J., and Mailhes, J. B. 1975. Toxicology of octabromobiphenyl and decabromodiphenyl oxide. Environ. Health Perspect. 11:153-161.
20. Schecter, A., Päpke, O., Joseph, J. E., and Tung, K. C. 2005. Polybrominated diphenyl ethers (PBDEs) in U.S. computers and domestic carpet vacuuming: possible sources of human exposure. J. Toxicol. Environ. Health A 68:501-513.
21. Schecter, A., Johnson-Welch, S., Tung, K. C., Harris, T. R., Papke, O., and Rosen, R. 2007. Polybrominated diphenyl ether (PBDE) levels in livers of US human fetuses and newborns. J. Toxicol. Environ. Health A 70:1-6.
22. Sjödin, A., Carlsson, H., Thuresson, K., Sjölin, S., Bergman, A., and Östman, C. 2001. Flame retardants in indoor air at an electronics recycling plant and at other work environments. Environ. Sci. Technol. 35: 448-454.
23. Stoker, T. E., Laws, S. C., Crofton, K. M., Hedge, J. M., Ferrell, J. M., and Cooper, R. L. 2004. Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols. Toxicol. Sci. 78:144-155.
24. Stoker, T. E., Cooper, R. L., Lambright, C. S., Wilson, V. S., Furr, J., and Gray, L. E. 2005. In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture. Toxicol. Appl. Pharmacol. 207:78-88.
25. Sudaryanto, A., Kajiwara, N., Takahashi, S., Muawanah, and Tanabe, S. 2008. Geographical distribution and accumulation features of PBDEs in human breast milk from Indonesia. Environ. Pollut. 151:130-138.
26. Talsness, C. E., Shakibaei, M., Kuriyama, S. N., Grande, S. W., Sterner-Kock, A., Schnitker, P., de Souza, C., Grote, K., and Chahoud, I. 2005. Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardant. Toxicol. Lett. 157:189-202.
27. Tseng, L. H., Lee, C. W., Pan, M. H., Tsai, S. S., Li, M. H., Chen, J. R., Lay, J. J., and Hsu, P. C. 2006. Postnatal exposure of the male mouse to 2,2′,3,3′,4,4′,5,5′,6,6′-decabrominated diphenyl ether: decreased epididymal sperm functions without alterations in DNA content and histology in testis. Toxicology 224:33-43.
28. Viberg, H., Fredriksson, A., Jakobsson, E., Orn, U., and Eriksson P. 2003. Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defined period of neonatal brain development. Toxicol. Sci. 76:112-120.
29. Viberg, H., Mundy, W., and Eriksson, P. 2008. Neonatal exposure to decabrominated diphenyl ether (PBDE 209) results in changes in BDNF, CaMKII and GAP-43, biochemical substrates of neuronal survival, growth, and synaptogenesis. Neurotoxicology 29:152-159.
30. Yen, P. M. 2001. Physiological and molecular basis of thyroid hormone action. Physiol. Rev. 81:1097-1142.
31. Zhou, T., Tayloy, M. M., DeVito, M. J., and Crofton, K. M. 2002. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicol. Sci. 66:105-116.