Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes

Journal of Biological Chemistry

Volumn 286, Issue 47, 2011, Pages 40750-40759

  Johnston, Wayne A ^a   Hunter, Dominic J B ^a   Noble, Christopher J ^a   Hanson, Graeme R ^a   Stok, Jeanette E ^a   Hayes, Martin A ^b   De Voss, James J ^a   Gillam, Elizabeth M J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

C-H BOND; CATALYTIC CYCLES; CO-EXPRESSION; CYP2C19; CYTOCHROME P450; DIFFERENCE SPECTROSCOPY; ELECTRON DONORS; ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY; HEPATOCYTES; IN-VITRO; IN-VIVO; INTACT CELLS; MONOOXYGENASES; NATIVE STATE; RAT HEPATOCYTES; RESTING STATE; SUBSTRATE BINDING; WHOLE CELL;

CELLS; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYMES; ESCHERICHIA COLI; IRON COMPOUNDS; MAMMALS; PARAMAGNETIC RESONANCE; PARAMAGNETISM; PORPHYRINS;

SUBSTRATES;

CYTOCHROME P450; CYTOCHROME P450 101A1; CYTOCHROME P450 176A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; FERRIC ION; FERROUS ION; HEME; OXYGEN; UNCLASSIFIED DRUG;

AERATION; AEROBIC CELL CULTURE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME KINETICS; ENZYME SUBSTRATE; ESCHERICHIA COLI; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REST; WHOLE CELL;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI; FERRIC COMPOUNDS; FERROUS COMPOUNDS; HEME; HEPATOCYTES; HUMANS; LIGANDS; MALE; OXIDATION-REDUCTION; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA; RATTUS;

EID: 81755171470     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.300871     Document Type: Article

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