The heritability of telomere length among the elderly and oldest-old

Twin Research and Human Genetics

Volumn 8, Issue 5, 2005, Pages 433-439

  Bischoff, Claus ^a   Graakjaer, Jesper ^a   Petersen, Hans Christian ^b   Hjelmborg, Jacob V B ^b   Vaupel, James W ^b   Bohr, Vilhelm ^c   Koelvraa, Steen ^a,d   Christensen, Kaare ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d LILLEBAELT HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; CELL CULTURE; CHROMOSOME REPLICATION; CHROMOSOME SIZE; CHROMOSOME STRUCTURE; DIZYGOTIC TWINS; FEMALE; HERITABILITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; PRIORITY JOURNAL; TELOMERE;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; MALE; MODELS, THEORETICAL; TELOMERE;

EID: 27144503866     PISSN: 18324274     EISSN: None     Source Type: Journal    
DOI: 10.1375/183242705774310141     Document Type: Article

References (32)

1. Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992). Telomere length predicts replicative capacity of human fibroblasts. Proceedings of the National Academy Science USA, 89, 10114-10118.
2. Bilaud, T., Brun, C., Ancelin, K., Koering, C. E., Laroche, T., & Gilson, E. (1997). Telomeric localization of TRF2, a novel human telobox protein. Nature Genetics, 17, 236-239.
3. Bischoff, C., Graakjaer, J., Petersen, H. C., Jeune, B., Bohr, V., Koelvraa, S., & Christensen, K. (2005). Telomere length among the elderly and oldest-old. Twin Research and Human Genetics, 8, 425-432.
4. Broccoli, D., Smogorzewska, A., Chong, L., & de Lange, T. (1997). Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics, 17, 231-235.
5. Chong, L., van Steensel, B., Broccoli, D., Erdjument-Bromage, H., Hanish, J., Tempst, P., & de Lange, T. (1995). A human telomeric protein. Science, 270, 1663-1667.
6. Christensen, K., Holm, N. V., McGue, M., Corder, L., & Vaupel, J. W. (1999). A Danish population-based twin study on general health in the elderly. Journal of Aging and Health, 11, 49-64.
7. Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992). Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. The EMBO Journal, 11, 1921-1929.
8. Garvik, B., Carson, M., & Hartwell, L. (1995). Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Molecular and Cell Biology, 15, 6128-6138
9. [published erratum in Molecular and Cell Biology, 1996, 16, 457].
10. Graakjaer, J., Bischoff, C., Korsholm, L., Holstebroe, S., Vach, W., Bohr, V. A., Christensen, K., & Kolvraa, S. (2003). The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life. Mechanisms of Ageing and Development, 124, 629-640.
11. Hiyama, K., Hirai, Y., Kyoizumi, S., Akiyama, M., Hiyama, E., Piatyszek, M. A., Shay, J. W., Ishioka, S., & Yamakido, M. (1995). Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. Journal of Immunology, 155, 3711-3715.
12. Jeanclos, E., Schork, N. J., Kyvik, K. O., Kimura, M., Skurnick, J. H., & Aviv, A. (2000). Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension, 36, 195-200.
13. Kim, S. H., Kaminker, P., & Campisi, J. (1999). TIN2, a new regulator of telomere length in human cells. Nature Genetics, 23, 405-412.
14. Kyvik, K. O., Christensen, K., Skytthe, A., Harvald, B., & Holm, N. V. (1996). The Danish Twin Register. Danish Medical Bulletin, 43, 467-470.
15. Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988). A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proceedings of the National Academy of Sciences USA, 85, 6622-6626.
16. Nawrot, T. S., Staessen, J. A., Gardner, J. P., & Aviv, A. (2004). Telomere length and possible link to X chromosome. Lancet, 363, 507-510.
17. Neale, M. C. (2000). Mx: Statistical modeling. Richmond, VA: Department of Psychiatry, Medical College of Virginia.
18. Neale, M. C., & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht, the Netherlands: Kluwer Academic.
19. Olovnikov, A. (1973). A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. Journal of Theoretical Biology, 41, 181-190.
20. Pickles, A. (1998). Generalized estimating equations. In P. Armitage & T. Colton (Eds.), Encyclopedia of biostatistics (vol. 2; pp. 1626-1637). Chichester, UK: Wiley & Sons.
21. Sandell, L. L., & Zakian, V. A. (1993). Loss of a yeast telomere: Arrest, recovery, and chromosome loss. Cell, 75, 729-739.
22. Shannon, K. M., Turhan, A. G., Chang, S. S., Bowcock, A. M., Rogers, P. C., Carroll, W. L., Cowan, M. J., Glader, B. E., Eaves, C. J., Eaves, A. C., & Kan, Y. W. (1989). Familial bone marrow monosomy 7: Evidence that the predisposing locus is not on the long arm of chromosome 7. Journal of Clinical Investigation, 84, 984-989.
23. Shannon, K. M., Turhan, A. G., Rogers, P. C., & Kan, Y. W. (1992). Evidence implicating heterozygous deletion of chromosome 7 in the pathogenesis of familial leukemia associated with monosomy 7. Genomics, 14, 121-125.
24. Shay, J. W., & Bacchetti, S. (1997). A survey of telomerase activity in human cancer. European Journal of Cancer, 33, 787-791.
25. Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994). Genetic determination of telomere size in humans: A twin study of three age groups. American Journal of Human Genetics, 55, 876-882.
26. Smith, S., Giriat, I., Schmitt, A., & de Lange, T. (1998). Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science, 282, 1484-1487. [See comments pp. 1395-1397].
27. Statacorp. (1999). Stata statistical software (Release 6.0) [Computer software]. College Station, TX: Stata Corporation.
28. Unryn, B. M., Cook, L. S., & Riabowol, K. T. (2005). Paternal age is positively linked to telomere length of children. Aging Cell, 4, 97-101.
29. van Steensel, B., & de Lange, T. (1997). Control of telomere length by the human telomeric protein TRF1. Nature, 385, 740-743. [See comments pp. 676-677].
30. Vasa-Nicotera, M., Brouilette, S., Mangino, M., Thompson, J. R., Braund, P., Clemitson, J. R., Mason, A., Bodycote, C. L., Raleigh, S. M., Louis, E., & Samani, N. J. (2005). Mapping of a major locus that determines telomere length in humans. American Journal of Human Genetics, 76, 147-151.
31. Vaziri, H., Schachter, F., Uchida, I., Wei, L., Zhu, X., Effros, R., Cohen, D., & Harley, C. B. (1993). Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. American Journal of Human Genetics, 52, 661-667.
32. Wright, W. E., Piatyszek, M. A., Rainey, W. E., Byrd, W., & Shay, J. W. (1996). Telomerase activity in human germline and embryonic tissues and cells. Developmental Genetics, 18, 173-179.