Lipid-lowering effect of artichoke on liver phosphatidate phosphohydrolase and plasma lipids in hyperlipidemic rats

Journal of Medicinal Plant Research

Volumn 5, Issue 19, 2011, Pages 4918-4924

  Heidarian, Esfandiar ^a   Jafari Dehkordi, Effat ^b   Seidkhani Nahal, Ali ^c  

^a SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ILAM UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Artichoke; Hyperlipidemia; Liver triglyceride; Phosphatidate phosphohydrolase; Plasma lipids

Indexed keywords

ANTIOXIDANT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; PHOSPHATIDATE PHOSPHATASE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICHOKE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIET THERAPY; DIETARY INTAKE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HYPERLIPIDEMIA; LIPID BLOOD LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; THERAPY EFFECT; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL;

CYNARA SCOLYMUS; HELIANTHUS; RATTUS;

EID: 81555217948     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Andersen C, Rayalam S, Della-Fera MA, Baile CA (2010). Phytochemicals and adipogenesis. Biofactors, 36: 415-422.
2. Benzie IF, Strain JJ (1996). The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Anal. Biochem., 239: 70-76.
3. Bradford MM (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254.
4. Brindley DN (2004). Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer. J. Cell. Biochem., 92: 900-912,
5. Brown JE, Rice-Evans CA (1998). Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radic. Res., 29: 247-255.
6. Carman GM, Han GS (2006). Roles of phosphatidate phosphatase enzymes in lipid metabolism. Trends Biochem. Sci., 31: 694-699.
7. Elabbadi N, Day CP, Gamouh A, Zyad A, Yeaman SJ (2005). Relationship between the inhibition of phosphatidic acid phosphohydrolase-1 by oleate and oleoyl-CoA ester and its apparent translocation. Biochim., 87: 437-443.
8. Fleming IN, Yeaman SJ (1995). Purification and characterization of Nethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver. Biochem. J., 308(Pt 3): 983-989.
9. Frishman WH (1998). Biologic markers as predictors of cardiovascular disease. Am. J. Med., 104: 18S-27S.
10. Gebhardt R (1998). Inhibition of cholesterol biosynthesis in primary cultured rat hepatocytes by artichoke (Cynara scolymus L.) extracts. J. Pharmacol. Exp. Ther., 286: 1122-1128.
11. Gould AL, Davies GM, Alemao E, Yin DD, Cook JR (2007). Cholesterol reduction yields clinical benefits: meta-analysis including recent trials. Clin. Ther., 29: 778-794.
12. Haghighi B, Honarjou S (1987). The effects of hydrazine on the phosphatidate phosphohydrolase activity in rat liver. Biochem. Pharmacol., 36: 1163-1165.
13. Heidarian E, Haghighi B (2008). Enzymological characteristic of plasma membrane phosphatidate phosphohydrolase (PAP2) from rat liver. Iran.J. Sci. Technol. A., 32: 117-122.
14. Heidarian E, Jafari-Dehkordi E, Seidkhani-Nahal A (2011). Effect of garlic on liver phosphatidate phosphohydrolase and plasma lipidlevels in hyperlipidemic rats. Food Chem. Toxicol., 49: 1110-1114.
15. Jemai H, Fki I, Bouaziz M, Bouallagui Z, El Feki A, Isoda H, Sayadi S (2008). Lipid-lowering and antioxidant effects of hydroxytyrosol and its triacetylated derivative recovered from olive tree leaves in cholesterol-fed rats. J. Agric. Food Chem., 56: 2630-2636.
16. Jiménez-Escrig A, Dragsted LO, Daneshvar B, Pulido R, Saura-Calixto F (2003). In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats. J. Agric. Food Chem., 51: 5540-5545.
17. Joy JF, Haber SL (2007). Clinical uses of artichoke leaf extract. Am. J. Health Syst. Pharm., 64: 1904, 1906-1909.
18. Juzyszyn Z, Czerny B, Myśliwiec Z, Pawlik A, Droździk M (2010). The effect of artichoke (Cynara scolymus L.) extract on respiratory chain system activity in rat liver mitochondria. Phytother. Res., 24 Suppl 2: S123-128.
19. Juzyszyn Z, Czerny B, Pawlik A, Drozdzik M (2008). The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells. Phytother. Res., 22: 1159-1161.
20. Küskü-Kiraz Z, Mehmetçik G, Dogru-Abbasoglu S, Uysal M (2010). Artichoke leaf extract reduces oxidative stress and lipoprotein dyshomeostasis in rats fed on high cholesterol diet. Phytother. Res., 24: 565-570.
21. Laker MF (2006). Cardiovascular disease prevention: the new Joint British Societies' guidelines. Ann. Clin. Biochem., 43: 335-339.
22. Lykkesfeldt J (2007). Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking. Clin. Chim. Acta., 380: 50-58.
23. McKenney JM (2001). Pharmacotherapy of dyslipidemia. Cardiovasc. Drugs Ther., 15: 413-422.
24. Miller CA (2001). Update on statins and other lipid-lowering drugs. Geriatr. Nurs., 22: 276-277.
25. Mulvihill EE, Huff MW (2010). Antiatherogenic properties of flavonoids: implications for cardiovascular health. Can. J. Cardiol., 26 Suppl A: 17A-21A.
26. Norman SR (1969). Preparation of lipid extracts. In: John MI. (Ed.), Methods of Enzymology. Academic Press, London, Vol. 14.
27. Ohkawa H, Ohishi N, Yagi K (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95: 351-358.
28. Ondrejovičová I, Muchová J, Mišľanová C, Nagyová Z, Ďuračková Z (2010). Hypercholesterolemia, oxidative stress and gender dependence in children. Prague Med. Rep., 111: 300-312.
29. Pérez-Garcia F, Adzet T, Canigueral S (2000). Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. Free Radic. Res., 33: 661-665.
30. Petersen KF, Shulman GI (2006). Etiology of insulin resistance. Am. J. Med., 119: S10-16.
31. Reue K, Phan J (2006). Metabolic consequences of lipodystrophy in mouse models. Curr. Opin. Clin. Nutr. Metab. Care, 9: 436-441.
32. Sciorra VA, Morris AJ (2002). Roles for lipid phosphate phosphatases in regulation of cellular signaling. Biochim. Biophys. Acta., 1582: 45-51.
33. Shimoda H, Ninomiya K, Nishida N, Yoshino T, Morikawa T, Matsuda H, Yoshikawa M (2003). Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action. Bioorg. Med. Chem. Lett., 13: 223-228.
34. Stone NJ (1996). Lipid management: current diet and drug treatment options. Am. J. Med., 101: 4A40S-48S; Discussion 48S-49S.
35. Sudhahar V, Kumar SA, Varalakshmi P, Sundarapandiyan R (2007). Mitigating role of lupeol and lupeol linoleate on hepatic lipemicoxidative injury and lipoprotein peroxidation in experimental hypercholesterolemia. Mol. Cell. Biochem., 295: 189-198.
36. Van Herpen NA, Schrauwen-Hinderling VB (2008). Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol. Behav., 94: 231-241.
37. Wang M, Simon JE, Aviles IF, He K, Zheng QY, Tadmor Y (2003). Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). J. Agric. Food Chem., 51: 601-608.
38. Wider B, Pittler MH, Thompson-Coon J, Ernst E (2009). Artichoke leaf extract for treating hypercholesterolaemia. Cochrane Database Syst. Rev., 7: CD003335.
39. Yanardag R, Peksel A, Yesilyaprak B, Doger MM, Arisan-Atac I (2005). Effects of a combination of niacin and chromium(III)-chloride on the skin and lungs of hyperlipemic rats. Biol. Trace Elem. Res., 103: 249-260.
40. Zapolska-Downar D, Zapolski-Downar A, Naruszewicz M, Siennicka A, Krasnodebska B, Kołdziej B (2002). Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes. Life Sci., 71: 2897-2808.