A review of the role of tissue repair as an adaptive strategy: Why low doses are often non-toxic and why high doses can be fatal

Food and Chemical Toxicology

Volumn 34, Issue 3, 1996, Pages 301-311

  Calabrese, E J ^a   Mehendale, H M ^b  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; CHLORDECONE;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; CHEMICAL INTERACTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; RAT; REVIEW; TISSUE REGENERATION;

ANIMALIA;

EID: 0030009784     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/0278-6915(95)00101-8     Document Type: Review

References (49)

1. Bell A. N., Young R. A., Lockard V. G. and Mehendale H. M. (1988) Protection of chlordecone-potentiated carbon tetrachloride hepatotoxicity and lethality by partial hepatectomy. Archives of Toxicology 61, 392-405.
2. Bertrand R., Solary E., Kohn K. W. and Pommer Y. (1993) Staurosporine may activate a final common pathway to apoptosis. Proceedings of the American Association for Cancer Research. Abstract no. 1735, vol. 34, p. 292. 19-22 May, Orlando, FL.
3. Bursch W., Lauer B., Timmermann-Trosiener I., Barthel G., Schuppler J. and Schulte-Hermann R. (1984) Controlled cell death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 5, 453-458.
4. 2 subpopulation in rat liver induced into mitosis by low level exposure to carbon tetrachloride: an adaptive response. Toxicology and Applied Pharmacology 121, 1-7.
5. 4 hepatotoxicity. Ecotoxicology and Environmental Safety 27, 105-106.
6. 4-hepatotoxicity. Journal of the American College of Toxicology. In press.
7. Chanda S. and Mehendale H. M. (1993) Heteroprotection by thioacetamide against acetaminophen lethality. Toxicologist 13, 32.
8. Curtis L. R., Williams W. L. and Mehendale H. M. (1979) Potentiation of the hepatotoxicity of carbon tetrachloride following pre-exposure to CD (Kepone) in the male rat. Toxicology and Applied Pharmacology 51, 283-293.
9. Faroon O. M. and Mehendale H. M. (1990) Bromotrichloromethane hepatotoxicity. Role of hepatocellular regeneration in recovery. Biochemical and histopathological studies in control and chlordecone pretreated male rats. Toxicologic Pathology 18, 667-677.
10. Fong I., Hulinsky I., Fortuna R. and Silink M. (1992) Mitotic activity and DNA synthesis of rat islet cells following partial pancreatectomy. Pancreas 7, 453-459.
11. Hunter A. L. and Klaassen C. D. (1975) Biliary excretion of colchicine. Journal of Pharmacology and Experimental Therapeutics 192, 605-617.
12. 2 apoptosis in L1210 cells. Proceedings of the American Association for Cancer Research. Abstract no. 663, vol. 34, pp. 112. 19-22 May, Orlando, FL.
13. Kirshner M. W. (1978) Microtubule assembly and nucleation. International Review of Cytology 54, 1-65.
14. 4 lethality by chlordecone. Toxicology Letters 11, 149-154.
15. R)-potentiated carbon tetrachloride hepatotoxicity in partially hepatectomized rats. A histomorphometric study. Journal of Applied Toxicology 9, 367-375.
16. Kodavanti P. R. S., Joshi U. M., Young R. A., Bell A. N. and Mehendale H. M. (1989a) Role of hepatocellular regeneration in chlordecone-potentiated hepatotoxicity of carbon tetrachloride. Archives of Toxicology 63, 367-375.
17. 4 by partial hepatectomy. Toxicologic Pathology 17, 494-505.
18. 4 in chlordecone, mirex, or phenobarbital pretreated rats. Toxicologic Pathology 20, 556-569.
19. 4 hepatotoxicity. Biochemical Pharmacology 40, 859-866.
20. 4-induced alterations of hepatic calmodulin and free calcium levels in rats pretreated with chlordecone. Hepatology 13, 230-238.
21. Kodavanti P. R. S., Rao V. C. and Mehendale H. M. (1993) Loss of calcium homeostasis leads to progressive phase of chlordecone-potentiated carbon tetrachloride hepatotoxicity. Toxicology and Applied Pharmacology 122, 77-87.
22. 2 block and apoptosis in L1210 cells by antitumor 1-nitro-9-aminoacridine (Nitracrine). Proceedings of the American Association for Cancer Research. Abstract no. 1732, vol. 34, pp. 291. 19-22 May, Orlando, FL.
23. Ledda-Columbano G. M., Coni P., Curto M., Giacomini L., Faa G., Oliverio S., Piacentini M. and Columbano A. (1991) Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide. American Journal of Pathology 139, 1099-1109.
24. Lockard V. G., Mehendale H. M. and O'Neal R. M. (1983a) Chlordecone-induced potentiation of carbon tetrachloride hepatotoxicity: a light and electron microscopic study. Experimental and Molecular Pathology 39, 230-245.
25. Lockard V. G., Mehendale H. M. and O'Neal R. M. (1983b) Chlordecone-induced potentiation of carbon tetrachloride hepatotoxicity: a morphometric and biochemical study. Experimental and Molecular Pathology 39, 246-256.
26. Manfredi J. J. and Horwitz S. B. (1984) An antimitotic agent with a new mechanism of action. Pharmacology and Therapeutics 25, 83-125.
27. Mangipudy R. S., Chanda S. and Mehendale H. M. (1993) Thioacetamide autoprotection. FASEB Journal 7, A40.
28. Marietta M. A., Hevel J. M., Olken N. M., Pufah R. A. and White K. A. (1993) Nitric oxide synthases. Proceedings of the American Association for Cancer Research 34, 583-584.
29. Mehendale H. M. (1984) Potentiation of halomethane hepatotoxicity: chlordecone and carbon tetrachloride. Fundamental and Applied Toxicology 4, 295-308.
30. 4 at nontoxic doses. Toxicology Letters 49, 215-241.
31. Mehendale H. M. (1990) Potentiation of halomethane hepatotoxicity by chlordecone: a hypothesis for the mechanism. Medical Hypotheses 33, 289-299.
32. Mehendale H. M. (1991) Commentary. Role of hepatocellular regeneration and hepatolobular healing in the final outcome of liver injury. A two-stage model of toxicity. Biochemical Pharmacology 42, 1155-1162.
33. Mehendale H. M. (1994a) Amplified interactive toxicity of chemicals at nontoxic levels: mechanistic considerations and implications to public health. Environmental Health Perspectives. 10 (Suppl. 9), 139-149.
34. Mehendale H. M. (1994b) Cellular and molecular foundations of hormetic mechanisms. In Proceedings of the Second BELLE Conference. Edited by E. J. Calabrese. pp. 111-141. Lewis Publishers, Chelsea, MI.
35. 4 by rats pretreated with chlordecone, mirex or phenobarbital. Toxicology and Applied Pharmacology 93, 247-256.
36. 3 hepatotoxicity. Experimental and Molecular Pathology 51, 31-47.
37. Mehendale H. M., Thakore K. N. and Rao V. C. (1994) Autoprotection: stimulated tissue repair permits recovery from injury. Journal of Biochemical Toxicology 9, 131-139.
38. Pritchard D. J. and Butler W. H. (1989) The mechanism of cell death in dimethylnitrosamine-induced hepatotoxicity. Journal of Pathology 158, 253-260.
39. 4 autoprotection. Toxicologic Pathology 19, 597-606.
40. Rao V. C. and Mehendale H. M. (1993) Effect of antimitotic agent, colchicine and carbon tetrachloride toxicity. Archives of Toxicology 67, 392-400.
41. Reddy J. N., Chiga M. and Svoboda D. (1969) Initiation of division cycle of rat hepatocytes following a single injection of thioacetamide. Laboratory Investigation 20, 405-411.
42. Reynolds E. S., Kanz M. F., Chieco P. and Moslen M. T. (1984) 1,1-dichloroethylene: an apoptotic hepatotoxin? Environmental Health Perspectives 57, 313-320.
43. Soni M. G. and Mehendale H. M. (1991a) Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: biochemical and histological studies. Toxicology and Applied Pharmacology 108, 46-57.
44. Soni M. G. and Mehendale H. M. (1991b) Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: regeneration studies. Toxicology and Applied Pharmacology 108, 58-66.
45. Soni M. G. and Mehendale H. M. (1993) Hepatic failure leads to lethality of chlordecone-amplified hepatotoxicity of carbon tetrachloride. Fundamental and Applied Toxicology 22, 442-450.
46. 4 hepatotoxicity and lethality. Journal of Hepatology 20, 267-274.
47. 4 autoprotection. Toxicologic Pathology 19, 47-58.
48. Tsukamoto I. and Kojo S. (1989) Effect of colchicine and vinchristine on DNA synthesis in regenerating rat liver. Biochimica et Biophysica Acta 1009, 191-193.
49. Xie K. and Fidler I. (1993) Induction of apoptosis in transformed fibroblasts can be mediated via endogenous and exogenous nitric oxide. Proceedings of the American Association for Cancer Research. Abstract no. 564, vol. 34, p. 95. 19-22 May, Orlando, FL.