Physiologically based modeling of the maximal effect of metabolic interactions on the kinetics of components of complex chemical mixtures

Journal of Toxicology and Environmental Health - Part A

Volumn 61, Issue 3, 2000, Pages 209-223

  Haddad, Sami ^a   Charest Tardif, Ginette ^a   Krishnan, Kannan ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE; DICHLOROMETHANE; ETHYLBENZENE; ORGANIC COMPOUND; STYRENE; TETRACHLOROETHYLENE; TOLUENE; TRICHLOROETHYLENE; XYLENE;

ADIPOSE TISSUE; ARTERIAL BLOOD; ARTICLE; BLOOD LEVEL; KINETICS; LIVER; LUNG; MATHEMATICAL ANALYSIS; METABOLISM; MODEL; PRIORITY JOURNAL; RISK ASSESSMENT; TISSUE PERFUSION; TOXICITY; TOXIN ANALYSIS; VENOUS BLOOD;

ADMINISTRATION, INHALATION; ANIMALS; BENZENE; BENZENE DERIVATIVES; DRUG INTERACTIONS; ENVIRONMENTAL POLLUTANTS; MALE; METHYLENE CHLORIDE; MODELS, ANIMAL; ORGANIC CHEMICALS; PREDICTIVE VALUE OF TESTS; RATS; RATS, SPRAGUE-DAWLEY; STYRENE; TETRACHLOROETHYLENE; TOLUENE; TRICHLOROETHYLENE; VOLATILIZATION; XYLENES;

EID: 0034644885     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/00984100050131350     Document Type: Article

References (30)

1. Agency for Toxic Substances and Disease Registry. 2000. Internet HazDat Database.
2. Andersen, M. E., Clewell, H. J. III, Gargas, M. L., MacNaughton, M. G., Reitz, R. H., Nolan, R. J., and McKenna, M. J. 1991. Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans. Toxicol. Appl. Pharmacol. 108:14-27.
3. Arms, A. D., and Travis, C. C. 1988. Reference Physiological Parameters in Pharmacokinetic Modeling. Washington, DC: Office of Risk Analysis, U.S. EPA. NTIS PB 88-196019.
4. Beliveau, M., Charest-Tardif, G., and Krishnan, K. In press. Blood:air partition coefficients of individual and mixtures of trihalomethanes. Chemosphere.
5. Bergeron, R. M., Desai, K., Serron, S. C., Cawley, G. F., Eyer, C. S., and Backes, W. L. 1999. Changes in the expression of cytochrome P450s 2B1, 2B2, 2E1, and 2C11in response to daily aromatic hydrocarbon treatment. Toxicol. Appl. Pharmacol. 157:1-8.
6. Fisher, J. W., Gargas, M. L., Allen, B. C., and Andersen, M. E. 1991. Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse. Toxicol. Appl. Pharmacol. 109:183-195.
7. Guengerich, F. P., Kim, D. H., and Iwasaki, M. 1991. Role of human cytochrome P-450 IIE1in the oxidation of many low molecular weight cancer suspect. Chem. Res. Toxicol. 4:168-179.
8. Haddad, S., and Krishnan K. 1998. Physiological modeling of toxicokinetic interactions: I mplications for mixture risk assessment. Environ. Health Perspect. 106 (suppl. 6):1377-1384.
9. Haddad, S., Tardif, R., Viau, C., and Krishnan, K. 1999a. A modeling approach to account for toxicokinetic interaction i n the calculation of biological hazard index for chemical mixtures. Toxicol. Lett. 108:303-308.
10. Haddad, S., Charest-Tardif, G., Tardif, R., and Krishnan, K. 1999b. Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons. Toxicol. Appl. Pharmacol. 161:249-257.
11. Haddad, S., Charest-Tardif, G., Tardif R., and Krishnan, K. 2000. Validation of a physiological modeling approach for extrapolating the occurrence of interactions from simple to complex chemical mixtures. Toxicol. Appl. Pharmacol., in press.
12. Krishnan, K., and Andersen, M. E. 1994. Physiologically based pharmacokinetic modeling in toxicology. In Principles and methods in toxicology, 3rd ed., ed. W. Hayes, pp. 149-187. New York: Raven Press.
13. Krishnan, K., and Brodeur, J. 1991. Toxicological consequences of combined exposure to environmental pollutants. Arch. Complex Environ. Stud. 3:1-106.
14. Kumai, M., Koizumi, A., Saito, K., Sakurai, H., Inoue, T., Takeuchi, Y., Hara, I., Ogata, M., Matsushita, T., and Ikeda, M. 1983. A nationwide survey on organic solvent components i n various solvent products: Part 2. Heterogeneous products such as paints, inks, and adhesives. Ind. Health 21:185-197.
15. Liira, J., Elovaara, R., Raunio, H., Riihimaki, V., and Engstrom, K. 1991. Metabolic i nteraction and disposition of methylethyl ketone and m-xylene in rats at single and repeated exposures. Xenobiotica 21:53-65.
16. Nakajima, T., Elovaara, E., Park, S. S., Gelboin, H. V., Hietanen, E., and Vainio, H. 1989. Immunochemical characterization of P-450 isozymes responsible for benzene oxidation in the rat liver. Carcinogenesis 10:1713-1717.
17. Nakajima, T., Elovaara, E., Park, S. S., Gelboin, H. V., Hietanen, E., and Vainio, H. 1990. Monoclonal antibody directed characterization of benzene, ethoxyresorufin and pentoxyresorufin metabolism i n rat liver microsomes. Biochem. Pharmacol. 40:1255-1261.
18. Nakajima, T., Wang, R., Elovaara, E., Park, S. S., Gelboin, H. V., Hiltman, E., and Vainio, H. 1991. Monoclonal antibody directed characterization of cytochrome P-450 isozymes responsible for toluene metabolism i n rat liver. Biochem. Pharmacol. 41:395-404.
19. Nakajima, T., Wang, R. S., Elovaara, E., Park, S. S., Gelboin, H. V., and Vainio, H. 1992. A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liver. Biochem. Pharmacol. 43:251-257.
20. Nakajima, T., Wang, R. S., Elovaara, E., Park, S. S., Gelboin, H. V., and Vainio, H. 1993. Cytochrome P450-related differences between rats and mice in the metabolism of benzene, toluene and trichloroethylene in liver microsomes. Biochem. Pharmacol. 45:1079-1085.
21. Poulin, P., and Krishnan, K. 1996. A mechanistic algorithm for predicting blood:air partition coefficients of organic chemicals with the consideration of reversible binding in hemoglobin. Toxicol. Appl. Pharmacol. 136:131-137.
22. Poulin, P., and Krishnan, K. 1999. Molecular structure-based prediction of the toxicokinetics of inhaled vapors in humans. Int. J. Toxicol. 18:7-18.
23. Ramsey, J. C., and Andersen, M. E. 1984. A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73:159-175.
24. Reitz, R. H., Gargas, M. L., Mendrala, A. I., and Schumann, A. 1996. In vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modeling in rats, mice, and humans. Toxicol. Appl. Pharmacol. 136:289-306.
25. Seedorf, L., and Olsen, E. 1990. Exposure to organic solvents—I. A survey on the use of solvents. Ann. Occup. Hyg. 34:371-378.
26. Simmons, J. E. 1996. Application of physiologically based pharmacokinetic modelling to combination toxicology. Food Chem. Toxicol. 34:1067-1673.
27. Tardif, R., Charest-Tardif, G., Brodeur, J., and Krishnan, K. 1997. Physiologically-based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans. Toxicol. Appl. Pharmacol. 144:120-134.
28. Tassaneeyakul, W., Birkett, D. J., Edwards, J. W., Veronese, M. E., Tassaneeyakul, W., Tukeg, R. H., and Miners, J. O. 1996. Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene. J. Pharmacol. Exp. Ther. 276:101-108.
29. Toftgard, R., and Nielsen, O. G. 1982. Effect of xylene and xylene isomers on cytochrome P-450 and in vitro enzymatic activities i n rat liver, kidney and lung. Arch. Toxicol. 23:197-212.
30. Ward, R. C., Travis, C. C., Hetrick, D. M., Andersen, M. E., and Gargas, M. L. 1988. Pharmacokinetics of tetrachloroethylene. Toxicol. Appl. Pharmacol. 93:108-117.