Phosphorylation of the Arp2 subunit relieves Auto-Inhibitory interactions for Arp2/3 complex activation

PLoS Computational Biology

Volumn 7, Issue 11, 2011, Pages

  Narayanan, Arjun ^a,b   LeClaire III, Lawrence L ^a,c   Barber, Diane L ^a   Jacobson, Matthew P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

^c UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; COMPLEX NETWORKS; MOLECULAR DYNAMICS; PROTEINS;

ACTIN FILAMENT; ACTIN-RELATED PROTEINS; ARP2/3 COMPLEX; CELLULAR STRUCTURE; ENDOSOMES; FILAMENT ASSEMBLY; LAMELLIPODIA; MOTILE CELLS; PROMOTING FACTORS; SALT BRIDGES;

PHOSPHORYLATION;

ACTIN RELATED PROTEIN 2; ACTIN RELATED PROTEIN 3; ACTIN RELATED PROTEIN 2-3 COMPLEX; ACTR2 PROTEIN, HUMAN;

ACTIN POLYMERIZATION; ARTICLE; CHEMICAL ANALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; GAIN OF FUNCTION MUTATION; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; ACTIN FILAMENT; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MUTATION; PHOSPHORYLATION; POLYMERIZATION; PROTEIN CONFORMATION; PROTEIN PROCESSING;

ACTIN CYTOSKELETON; ACTIN-RELATED PROTEIN 2; ACTIN-RELATED PROTEIN 2-3 COMPLEX; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PHOSPHORYLATION; POLYMERIZATION; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 81355154116     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002226     Document Type: Article

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