Replication pauses of the Wild-Type and mutant mitochondrial DNA polymerase gamma: A simulation study

PLoS Computational Biology

Volumn 7, Issue 11, 2011, Pages

  Song, Zhuo ^a   Cao, Yang ^b   Samuels, David C ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; STOCHASTIC MODELS; STOCHASTIC SYSTEMS;

DNA COMPLEX; DNA POLYMERASE; DNA POLYMERIZATION; EXONUCLEASE; EXONUCLEASE ACTIVITY; MITOCHONDRIAL DNA; POLYMERASE Γ; SIMULATION STUDIES; STOCHASTIC SIMULATIONS; WILD TYPES;

NUCLEOTIDES;

DNA DIRECTED DNA POLYMERASE GAMMA; EXONUCLEASE; MITOCHONDRIAL DNA; DNA DIRECTED DNA POLYMERASE; POLG PROTEIN, MOUSE;

ARTICLE; CALCULATION; CONTROLLED STUDY; DNA REPLICATION; DNA STRAND; MITOSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POINT MUTATION; POLYMERIZATION; SIMULATION; STOCHASTIC MODEL; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; COMPUTER SIMULATION; GENETICS; MUTATION; STATISTICS; TRANSGENIC MOUSE;

ANIMALS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DNA REPLICATION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; MICE; MICE, TRANSGENIC; MODELS, GENETIC; MUTATION; STOCHASTIC PROCESSES;

EID: 81355132946     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002287     Document Type: Article

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