Effects of aminoguanidine and desferrioxamine on some vascular and biochemical changes associated with streptozotocin-induced hyperglycaemia in rats

Pharmacological Research

Volumn 43, Issue 3, 2001, Pages 233-240

  El Khatib, Aiman S ^a   Moustafa, Adel M ^a   Abdel Aziz, Abdel Aziz H ^a   Al Shabanah, Othman A ^a   El Kashef, Hassan A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Aminoguanidine; Desferrioxamine; Oxidative stress; Rat aorta; Streptozotocin

Indexed keywords

AMINOGUANIDINE; DEFEROXAMINE; FREE RADICAL; GLUCOSE; GLUTATHIONE PEROXIDASE; LIPID PEROXIDE; SCAVENGER; THIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SAFETY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLYCOSYLATION; HYPERGLYCEMIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0034958078     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2000.0772     Document Type: Article

References (59)

1. Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications
2. The potential of gliclazide, a sulphonylurea to influence the oxidative processes within the pathogenesis of diabetic vascular disease
3. Neurovascular dysfunction in diabetic rats. Potential contribution of auto-oxidation and free radicals examined using transition metal chelating agents
4. Diabetes-induced endothelial dysfunction is prevented by long-term treatment with the modified iron chelator, hydroxylethyl starch conjugated-desferrioxamine
5. Host biochemical defense mechanisms against prooxidants
6. Free radicals and ischaemic tissue injury
7. An introduction to free radical biochemistry
8. Biologically active free radicals and their scavengers: A review
9. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking
10. Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: Aminoguanidine ameliorates the overexpression of tumor necrosis factor-alpha and inducible nitric oxide synthase in diabetic rat glomeruli
11. Vascular hypertrophy in experimental diabetes. Role of advanced glycation end products
12. Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozotocin-induced diabetic rat
13. Aminoguanidine a novel inhibitor of nitric oxide formation prevents diabetic vascular dysfunction
14. Therapeutic interventions for nephropathy in type I diabetes mellitus
15. Nitric oxide: Physiology and pharmacology
16. Constitutive nitric oxide synthase (cNOS) activity in Langerhans islets flora streptozotocin diabetic rats
17. Endothelial dysfunction in diabetes mellitus
18. Stimulation of nitric oxide synthase during oxidative endothelial cell injury
19. G-monomethyl-L-arginine on the onset of diabetes in spontaneous diabetic BB rats
20. Nitric oxide synthase activity and L-arginine metabolism in the retinas from streptozotocin-induced diabetic rats
21. Effects of aminoguanidine on structural alterations of microvessels in peripheral nerve of streptozotocin diabetic rats
22. Protection against tissue damage in vivo by desferrioxamine: What is its mechanism of action?
23. Modulation of platelet function by free radicals and free radical scavengers
24. Hyperglycaemia increased the responsiveness of isolated rabbit's pulmonary arterial rings to serotonin
25. Determination of blood glucose using 4-aminophenazone as oxygen acceptor
26. Determination of MDA precursor in tissues by TBA test
27. Intracellular and extracellular sulfhydryl levels in rheumatoid arthritis
28. Improved method for the determination of blood glutathione
29. Superoxide dismutase & glutathione peroxidase activities in neutrophils from selenium deficient and copper deficient cattle
30. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
31. An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma
32. S-methyl-L-thiocitrulline counteracts interleukin 1 beta-induced suppression of pancreatic islet function in vitro, but does not protect against multiple low-dose streptozotocin-induced diabetes in vivo
33. Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets
34. Nitric oxide generation from streptozotocin
35. Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology and oxygen free radicals
36. The effect of desferrioxamine and ascorbate on oxidative stress in the streptozotocin diabetic rat
37. Effect of aminoguanidine on lipid peroxidation and activities of antioxidant enzymes in diabetic kidney
38. Effect of aminoguanidine on erythrocyte lipid peroxidation and activities of antioxidant enzymes in experimental diabetes
39. Effect of aminoguanidine on lipid peroxidation in streptozotocin-induced diabetic rats
40. Free radicals, antioxidants, and human disease: Curiosity, cause, or consequence?
41. Increased lipoperoxide value and glutathione peroxidase activity in blood plasma of type 2 (non-insulin-dependent) diabetic women
42. Effect of aminoguanidine on the generation of superoxide anion and nitric oxide by peripheral blood granulocytes of rats with streptozotocin-induced diabetes
43. Serum antioxidant status in streptozotocin-induced diabetic rat
44. The influence of high glucose levels and/or hyperosmolarity on rat isolated aorta
45. The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats
46. Effects of streptozotocin-induced diabetes on vascular reactivity in genetically hyperinsulinaemic obese Zucker rats
47. Metabolic and vascular factors in the pathogenesis of diabetic neuropathy
48. The endothelial cell as a metabolic and endocrine organ
49. Effect of aminoguanidine on optic nerve involvement in experimental diabetic rats
50. Aminoguanidine prevents the decreased myocardial compliance produced by streptozotocin-induced diabetes mellitus in rats
51. Mechanisms that may be involved in calcium tolerance of the diabetic heart
52. Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation
53. Effects of aminoguanidine and N(G)-nitro-L-arginine methyl ester on vascular responses of aortae and lungs from streptozotocin-diabetic rats
54. Glucose-induced metabolic imbalances in the pathogenesis of diabetic vascular disease
55. Oxidative damage in neurodegenerative disease
56. Superoxide radical and superoxide dismutases
57. Superoxide radical: An endogenous toxicant
58. Oxygen free radical scavengers and immune destruction of murine islets in allograft rejection and multiple low dose streptozotocin-induced insulitis
59. Inhibition of the iron-catalyzed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine