A dominant negative inhibitor of the Egr family of transcription regulatory factors suppresses cerebellar granule cell apoptosis by blocking c-Jun activation

Journal of Neuroscience

Volumn 21, Issue 16, 2001, Pages 5893-5901

  Levkovitz, Yechiel ^a   Baraban, Jay M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

C Jun; Cytosine arabinoside; Egr1; JNK; MEKK1; Zif268

Indexed keywords

CYTARABINE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; POTASSIUM; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EGR 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENZYME ACTIVATION; GENE CONSTRUCT; GRANULE CELL; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; TRANSCRIPTION REGULATION;

EID: 0035882383     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-16-05893.2001     Document Type: Article

References (44)

1. A late phase of cerebellar long-term depression requires activation of CaMKIV and CREB
2. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
3. Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals
4. An enhanced expression of the immediate early gene, Egr-1, is associated with neuronal apoptosis in culture
5. Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1
6. DNA binding site of the growth factor-inducible protein Zif268
7. The mechanism of Ara-C-induced apoptosis of differentiating cerebellar granule neurons
8. Ionizing radiation down-regulates p53 protein in primary Egr-1 -/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis
9. Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
10. Cytosine arabinoside induces apoptosis in cerebellar neurons in culture
11. Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
12. Regulation of neuronal survival by the serine-threonine protein kinase Akt
13. Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons
14. Altered gene expression in neurons during programmed cell death: Identification of c-Jun as necessary for neuronal apoptosis
15. Early growth response protein 1 (Egr-1): Prototype of a zinc finger family of transcription factors
16. Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen-activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells
17. Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training
18. c-Jun and Egr-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure
19. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
20. Inhibition of JNK by overexpression of the JNK binding domain of JIP-1 prevents apoptosis in sympathetic neurons
21. Egr-1 inhibits apoptosis during the UV response: Correlation of cell survival with Egr-1 phosphorylation
22. Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: Critical role of the p38 C-terminal domain in its negative regulation
23. cAMP response element-binding protein in the amygdala is required for long- but not short-term conditioned taste aversion memory
24. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
25. Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation
26. Blockade of NGF-induced neurite outgrowth by a dominant-negative inhibitor of the Egr family of transcription regulatory factors
27. Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells
28. Role of EGR-1 in thapsigargin-inducible apoptosis in the melanoma cell line A375-C6
29. Base sequence discrimination by zinc finger DNA binding domains
30. Major Egr3 isoforms are generated via alternate translation start sites and differ in their abilities to activate transcription
31. The EGR family of transcription-regulatory factors: Progress At the interface of molecular and systems neuroscience
32. Functional comparison of Egr3 transcription factor isoforms: Identification of an activation domain in the N-terminal segment absent from Egr3β, a major isoform expressed in brain
33. Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: Its role in zinc-induced neuronal death
34. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons
35. CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin
36. DNA-binding specificity of NGFI-A and related zinc finger transcription factors
37. Death-signalling cascade in mouse cerebellar granule neurons
38. Observations on rat cerebellar cells in vitro: Influence of substratum, potassium concentration and relationship between neurones and astrocytes
39. Surfing the p53 network
40. Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons
41. p38 mitogen-activated protein kinase regulates low potassium-induced c-Jun phosphorylation and apoptosis in cultured cerebellar granule neurons
42. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
43. The JIP group of mitogen-activated protein kinase scaffold proteins
44. Apoptosis in the nervous system